Biovac B 100mcg Injection: Complete Guide to Uses, Side Effects, and Safety
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or wheezing after the injection.
- Swelling of the face, lips, tongue, or throat.
- A fast heartbeat with dizziness or fainting.
- A widespread itchy rash or hives after vaccination.
- High fever that does not settle within 48 hours.
- Sudden weakness, tingling, or difficulty walking after vaccination.
- Unusual bruising or bleeding after the injection.
- Severe pain, redness, or swelling that keeps getting worse at the injection site.
If experiencing severe symptoms, call emergency services immediately.
What is biovac b 100mcg injection used for?
This medicine is a 100 microgram hepatitis B vaccine injection made using recombinant DNA technology. It is given into the muscle to prevent hepatitis B infection by helping the body make protective antibodies. It is commonly used for adults, dialysis patients, healthcare workers, and people at high risk of hepatitis B. It does not treat an existing hepatitis B infection.
- Generic Name: Hepatitis B Vaccine (rDNA) (100mcg)
- Manufacturer: Wockhardt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 biovac b 100mcg injection के बारे में (Hindi Summary)
उपयोग: यह दवा हेपेटाइटिस बी संक्रमण से बचाव के लिए दी जाने वाली टीका है। इसे रीकॉम्बिनेंट डीएनए तकनीक से बनाया जाता है और यह 100 माइक्रोग्राम की इंजेक्शन के रूप में उपलब्ध है। यह टीका शरीर में हेपेटाइटिस बी वायरस के खिलाफ सुरक्षात्मक एंटीबॉडी बनाती है, जिससे भविष्य में होने वाले संक्रमण से बचाव होता है। यह नवजात शिशुओं, बच्चों, बड़ों, स्वास्थ्यकर्मियों, डायलिसिस पर चल रहे मरीजों और उन लोगों के लिए दी जाती है जिन्हें संक्रमण का खतरा अधिक है। यह टीका हेपेटाइटिस बी का इलाज नहीं करती, बल्कि इससे बचाव करती है। पूरी सुरक्षा के लिए डॉक्टर द्वारा बताई गई सभी खुराकें समय पर लगवाना जरूरी है।
साइड इफेक्ट्स: इस टीके के बाद ज्यादातर लोगों को कोई गंभीर परेशानी नहीं होती। इंजेक्शन वाली जगह पर दर्द, लालिमा या सूजन आ सकती है। कुछ लोगों को थकान, हल्का सिरदर्द, हल्का बुखार, जी मिचलाना या चक्कर आ सकते हैं। ये आमतौर पर एक से तीन दिन में अपने आप ठीक हो जाते हैं। बहुत कम लोगों में तेज एलर्जी हो सकती है, जिसमें सांस लेने में तकलीफ, चेहरे या गले में सूजन, तेज धड़कन या शरीर पर चकत्ते दिख सकते हैं। ऐसा होने पर तुरंत डॉक्टर से मिलें। टीके के बाद कोई भी असामान्य लक्षण दिखे तो स्वास्थ्यकर्मी को जरूर बताएं।
सुरक्षा सलाह: यह टीका सिर्फ प्रशिक्षित स्वास्थ्यकर्मी द्वारा ही लगाया जाना चाहिए, इसे खुद न लगाएं। टीका लगवाने से पहले डॉक्टर को अपनी सभी बीमारियों, दवाओं और पहले हुई किसी एलर्जी के बारे में बताएं। अगर आपको यीस्ट से एलर्जी है या पहले किसी हेपेटाइटिस बी टीके से गंभीर एलर्जी हुई है, तो यह टीका न लगवाएं। तेज बुखार या गंभीर बीमारी के दौरान टीका लगवाने से बचें और ठीक होने के बाद ही लगवाएं। गर्भवती महिलाएं और स्तनपान कराने वाली महिलाएं डॉक्टर की सलाह से यह टीका लगवा सकती हैं। टीके के बाद डॉक्टर द्वारा बताए गए समय तक क्लिनिक में रुकें। अपना टीकाकरण कार्ड संभालकर रखें और सभी खुराकें समय पर पूरी करें।
💊 biovac b 100mcg injection Uses & Benefits
[{"condition":"Prevention of hepatitis B infection","description":"This medicine stimulates protective antibodies against the hepatitis B surface antigen and prevents acute and chronic hepatitis B infection in children and adults.","evidence":"Well-established"},{"condition":"Prevention of hepatitis B in newborns of carrier mothers","description":"Given soon after birth along with hepatitis B immune globulin, this vaccine reduces mother-to-child transmission of hepatitis B.","evidence":"Well-established"},{"condition":"Prevention of hepatitis B in healthcare workers and high-risk groups","description":"Recommended for healthcare workers, laboratory staff, dialysis patients, people who inject drugs, and people with multiple sexual partners.","evidence":"Well-established"},{"condition":"Prevention of hepatitis B in people with chronic liver disease or HIV","description":"Vaccination reduces the risk of additional liver injury from hepatitis B in people who already have liver disease or weakened immunity.","evidence":"Well-established"},{"condition":"Prevention of hepatitis D infection","description":"Because hepatitis D virus can only infect people who already have hepatitis B, preventing hepatitis B also prevents hepatitis D.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Post-exposure prophylaxis after needlestick injury","description":"Sometimes used together with hepatitis B immune globulin after a needlestick or sexual exposure in people who are not already immune.","evidence":"Established in guidelines"},{"condition":"Prevention of hepatitis B after organ transplantation","description":"May be used in some transplant programs to protect patients who receive organs from donors with hepatitis B core antibodies.","evidence":"Limited"}]
Primary treatment for: Hepatitis B prevention
Also treats: Hepatitis D prevention, Chronic liver disease prevention, Liver cancer risk reduction
📋 Drug Information
| Generic Name(s) | Hepatitis B Vaccine (rDNA) (100mcg) |
| Brand Name | biovac b 100mcg injection |
| Manufacturer | Wockhardt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | VACCINES |
| Action Class | Subunit (Purified antigen) |
| Route of Administration | Parenteral (intramuscular injection) |
| Storage | Store this medicine in a refrigerator at 2 to 8 degrees Celsius. Do not freeze it. Keep it in the original carton to protect it from light. Do not use it if it has been frozen. Before use, the vaccine may be brought to room temperature, but it should not be left out of the refrigerator for long periods. |
| Shelf Life | The shelf life is usually 24 to 36 months from the date of manufacture when stored correctly at 2 to 8 degrees Celsius. Always check the expiry date on the pack before use. |
| WHO Guideline | The World Health Organization recommends hepatitis B vaccination for all infants as soon as possible after birth, preferably within 24 hours, followed by additional doses to complete the series. WHO also recommends vaccination for healthcare workers, people with chronic liver disease, people on dialysis, people who inject drugs, and other high-risk groups. The exact number of doses and schedule may vary by country and product. |
| ICMR Guideline | Indian Council of Medical Research and national immunization guidelines recommend hepatitis B vaccination for all infants as part of the universal immunization programme, with the first dose at birth. Adult vaccination is recommended for healthcare workers, dialysis patients, people with chronic liver disease, and other high-risk groups. The 100 microgram strength may be used for adults who need a stronger response, as advised by a clinician. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine contains purified hepatitis B surface antigen (HBsAg) made by recombinant DNA technology. The antigen is adsorbed onto an adjuvant, usually aluminium hydroxide or a similar aluminium salt. After injection, the antigen is taken up by antigen-presenting cells such as dendritic cells and macrophages. These cells process the antigen and present it to helper T cells, which then activate B cells. The activated B cells produce antibodies that specifically bind to the hepatitis B surface antigen. These anti-HBs antibodies neutralise the virus if it later enters the body and prevent it from attaching to and infecting liver cells. The vaccine also creates memory B cells and memory T cells, so the immune system can respond quickly on future exposure. Because the vaccine contains only the surface protein and no live virus, it cannot cause hepatitis B infection. Protection is measured by the level of anti-HBs antibodies in the blood, and a level of at least 10 milli-international units per millilitre is generally accepted as protective.
Mechanism Steps
💡 How to Take biovac b 100mcg injection
Strength: Injection containing 100 micrograms of hepatitis B surface antigen (rDNA) per dose.
Dosage Information
| Adult Dosage | For adults, this 100 microgram strength is given as an intramuscular injection, usually into the deltoid muscle. The number of doses and the interval between them depend on the reason for vaccination and the person's health status. A common schedule is three doses given at zero, one, and six months, but other schedules such as zero, one, two, and twelve months may be used for dialysis patients or people with weakened immunity. The dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and the person's immune status. Do not self-administer this injection. |
| Pediatric Dosage | Pediatric dosing is not established from available information for this specific 100 microgram strength. For children and newborns, doctors usually use a lower-strength hepatitis B vaccine and follow the national immunization schedule. Consult a pediatrician for the correct vaccine strength and schedule for your child. |
| Elderly Dosage | Older adults often respond less strongly to hepatitis B vaccines. The 100 microgram strength may be chosen for older adults to improve the chance of protection. The schedule is the same as for other adults, but antibody levels may be checked after the series in some people. Dose must be individualized by a qualified clinician. |
| Renal Impairment | People with kidney failure, especially those on dialysis, respond poorly to standard hepatitis B vaccine doses. The 100 microgram strength is often used for dialysis patients, and additional doses or booster doses may be needed. Antibody levels should be checked after vaccination, and booster doses may be given when levels fall. Dose and schedule must be individualized by a qualified clinician. |
| Hepatic Impairment | No dose adjustment is needed for liver disease. People with chronic liver disease are encouraged to receive this vaccine because hepatitis B can cause further liver damage. Dose must be individualized by a qualified clinician. |
| Maximum Daily Dose | This vaccine is not given daily. The maximum dose is one injection of the prescribed strength per scheduled visit, as determined by the clinician. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of biovac b 100mcg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Immunosuppressants | Major | |
| Hepatitis B immune globulin | Moderate | |
| Other vaccines | Moderate | |
| Antimalarials | Moderate | |
| Paracetamol | Minor | |
| Ibuprofen | Minor | |
| Routine vitamins | Minor | |
| Chemotherapy | Major | |
| High-dose corticosteroids | Major | |
| Tacrolimus | Major |
🚨 Major Interactions
- Immunosuppressants such as high-dose corticosteroids, chemotherapy, or tacrolimus
- Hepatitis B immune globulin
⚡ Moderate Interactions
- Other vaccines given at the same visit
- Antimalarial medicines such as chloroquine
🍷 Alcohol Interaction
Alcohol does not directly interact with this vaccine. However, heavy alcohol use can weaken the immune response and is harmful to the liver, especially in people at risk of hepatitis B. It is best to avoid heavy drinking around the time of vaccination and to follow your doctor's advice about safe alcohol limits.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Severe allergic reaction to a previous dose of any hepatitis B vaccine.","Known severe allergy to yeast or to any component of this vaccine.","Moderate or severe acute illness with fever on the day of vaccination; wait until recovery.","This vaccine should not be used to treat an active hepatitis B infection."]
⚠️ Warnings & Precautions
["Tell your doctor if you have a bleeding disorder or are taking blood thinners, because intramuscular injections can cause bleeding.","Tell your doctor if you have a weakened immune system, because the vaccine may not work as well.","Stay in the clinic for the recommended observation period after the injection in case of a rare allergic reaction.","Do not use this vaccine if the liquid looks cloudy or contains particles.","Keep a record of every dose so the schedule can be completed correctly.","This vaccine does not protect against hepatitis A, hepatitis C, or hepatitis E.","People who are already infected with hepatitis B will not benefit from this vaccine for that infection.","Fainting can occur after any injection, especially in young people; sit or lie down if you feel dizzy."]
🤱 Lactation Safety
This vaccine is considered safe during breastfeeding. It does not pass into breast milk in a way that harms the baby, and breastfeeding can continue normally after vaccination.
💊 Overdose Management
Overdose with this vaccine is very unlikely because it is given by a healthcare professional as a single measured dose. If more than the recommended dose is given accidentally, the person should be observed for local reactions and any signs of allergic reaction. Treatment is supportive, and there is no specific antidote. Contact a doctor or poison control centre for advice if a large accidental dose is suspected.
⏰ Missed Dose
If you miss a scheduled dose of this vaccine, contact your doctor or vaccination clinic as soon as possible to arrange the next dose. The series does not need to be started again from the beginning if a dose is delayed. Your doctor will decide the best time to continue the schedule based on how long the gap has been.
Additional Safety Advice
This medicine must be given only by a trained healthcare professional, so do not try to inject it yourself. Tell your doctor about all your medical conditions, especially if you have a weakened immune system, are on dialysis, have a bleeding disorder, or are taking blood thinners. Tell your doctor if you are allergic to yeast or to any vaccine. If you are pregnant or planning pregnancy, this vaccine can still be given when there is a clear risk of hepatitis B infection, because the vaccine is not a live vaccine and cannot cause hepatitis B. If you are breastfeeding, this vaccine is considered safe. Do not receive this vaccine if you have a high fever or a serious illness right now; wait until you have recovered. Keep your vaccination card safe and bring it to every visit so your doctor can record each dose correctly. Complete the full series as advised, because fewer doses may leave you unprotected. After the injection, stay in the clinic for the observation period your doctor recommends. Report any severe or unusual reaction immediately. Do not share this medicine with anyone else, and do not use a dose that looks cloudy or has particles in it.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Older adults may have a weaker immune response to hepatitis B vaccines. The 100 microgram strength is sometimes chosen for older adults to improve the chance of protection. After the series, your doctor may check your antibody level and advise a booster if needed. Older adults with other medical conditions should discuss the timing of vaccination with their doctor.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy and are at risk of hepatitis B, you can receive this vaccine before or during pregnancy. The vaccine is not a live vaccine and is considered safe in pregnancy. Completing the series before pregnancy gives you the best protection. Discuss your vaccination status with your doctor as part of your pre-pregnancy planning.
🏥 Post-Surgery Considerations
This vaccine can be given after surgery once you are medically stable. If you had surgery because of a hepatitis B-related liver problem, your doctor will decide the best time to vaccinate. Tell your surgical team about your vaccination history, especially if you received hepatitis B immune globulin or blood products.
🦷 Dental Procedures
There is no need to stop or delay this vaccine because of dental work. If you are due for a dose, you can receive it before or after a dental procedure. Tell your dentist about your vaccination history if you are in a high-risk group. Dental staff should also be vaccinated against hepatitis B as part of workplace safety.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
There is no need to avoid exercise after this vaccine. If you feel tired or have a sore arm, you can take it easy for a day. Avoid heavy arm exercises for a day or two if the injection site is painful. Drink enough water and rest if you develop a mild fever.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This vaccine usually has little or no impact on your daily work. Most people can return to work or school right after the injection. If you feel tired, have a mild fever, or have a sore arm, you may want to avoid heavy physical work for a day. Healthcare workers should follow their workplace vaccination policy and keep a record of their doses.
🛑 When to Stop This Medicine
You should not stop the hepatitis B vaccine series on your own. If you have a severe allergic reaction or a serious side effect, your doctor will decide whether to stop or change the vaccine. If you miss a dose, do not stop the series; contact your clinic to reschedule. Always consult your doctor before deciding to stop or delay any dose.
📅 Long-Term Use Effects
Long-term protection after a complete hepatitis B vaccine series is excellent. In healthy people, protective antibody levels may slowly fall over the years, but memory cells usually provide continued protection, and boosters are generally not needed. People with weakened immunity or on dialysis may lose protection sooner and may need periodic antibody testing and booster doses. There are no known long-term harmful effects from this vaccine. It does not cause chronic illness, autoimmune disease, or infertility. Regular follow-up with your doctor is important if you are in a high-risk group.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Provides ready-made antibodies for immediate, short-term protection after exposure, but does not give long-term immunity.
Evidence: Well-establishedProtects against both hepatitis A and hepatitis B in one product for people who need both vaccines.
Evidence: Well-establishedUsing condoms, not sharing needles, and following workplace safety rules reduce the risk of hepatitis B but do not replace vaccination.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This vaccine can be given at the same visit as most other vaccines, including hepatitis A, diphtheria, tetanus, pertussis, polio, Haemophilus influenzae type b, and pneumococcal vaccines. Different vaccines should be given at different injection sites with separate syringes. Live vaccines can also be given at the same time or at least four weeks apart. If you are planning to receive other vaccines, tell your doctor so the schedule can be planned properly.
📦 Storage Guide
✅ DO
Store in a refrigerator at 2 to 8 degrees Celsius.
❌ DON'T
Do not freeze the vaccine.
✅ DO
Keep the vaccine in its original carton to protect it from light.
❌ DON'T
Do not transfer it to an unmarked container.
✅ DO
Check the expiry date before use.
❌ DON'T
Do not use the vaccine if it is past its expiry date.
✅ DO
Keep the vaccine in the cold chain during transport.
❌ DON'T
Do not leave it at room temperature for long periods.
✅ DO
Discard the vaccine if it has been frozen or looks cloudy.
❌ DON'T
Do not shake the vaccine vigorously.
✈️ Traveling with This Medicine
If you are travelling and need this vaccine, carry it in its original packaging in a cool box with ice packs, and keep it between 2 and 8 degrees Celsius. Do not freeze it. Carry a copy of your prescription and your vaccination card, because some countries may ask for proof of vaccination or a doctor's note. If you are travelling across time zones, the vaccine schedule is not usually affected because doses are given weeks or months apart, but confirm the dates with your doctor before you travel. If you are going to a country where hepatitis B is common, plan your vaccination series well in advance so that you are protected before you travel. Check customs rules for carrying medical injections and keep the vaccine in your hand luggage if you are flying.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Protective antibodies usually begin to appear within two to four weeks after the first dose, but full protection is reached only after the complete series is finished.
A: Most people need three doses, but some people, such as dialysis patients, may need four doses or a different schedule. Your doctor will decide the best schedule for you.
A: No. This vaccine contains only a purified surface protein made by recombinant DNA technology. It does not contain live virus and cannot cause hepatitis B infection.
A: This vaccine is not a live vaccine and is considered safe during pregnancy when there is a clear risk of hepatitis B infection. Discuss it with your doctor before receiving it.
A: The most common side effects are soreness, redness, or swelling at the injection site, tiredness, mild headache, and low-grade fever. These usually settle within one to three days.
A: Healthy people who complete the full series usually do not need a booster. People on dialysis or with weakened immunity may need periodic antibody checks and booster doses.
🤔 Common Patient Concerns
🔄 Substitutes for biovac b 100mcg injection
View AllAlternative brands with exact same active ingredient:
-
hepagen plus 100mcg injectionVhb Life Sciences Inc ₹528.00 24.6% CHEAPER
-
hepb 100mcg injectionSynergy Diagnostics Pvt Ltd ₹6,875.00 882.1% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This vaccine can cause hepatitis B infection.
Fact: This vaccine contains only a purified surface protein made by recombinant DNA technology. It does not contain live virus and cannot cause hepatitis B infection. - Myth: One dose is enough for lifelong protection.
Fact: Most people need a complete series of doses to build reliable protection. The exact schedule is decided by your doctor. - Myth: This vaccine is only for babies.
Fact: This vaccine is recommended for people of all ages who are at risk of hepatitis B, including adults, healthcare workers, and dialysis patients. - Myth: This vaccine can be given to treat hepatitis B.
Fact: This vaccine is for prevention only. It does not treat or cure an existing hepatitis B infection. - Myth: The vaccine weakens the immune system.
Fact: This vaccine strengthens the immune system's ability to fight hepatitis B. It does not weaken immunity.
🔄 Alternative Options
Generic Alternatives
- Hepatitis B Vaccine (rDNA) 100 mcg injection
Brand Alternatives
- Biovac B 100mcg Injection