Human Mixtard 70/30 Suspension for Injection 100IU/ml: Complete Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe hypoglycemia with confusion, seizures, or unconsciousness
- Signs of anaphylaxis: swelling of face, lips, throat, difficulty breathing
- Persistent vomiting or diarrhea leading to dehydration
- High blood sugar with fruity breath, nausea, or rapid breathing (ketoacidosis)
- Injection site infection with redness, warmth, or pus
- Sudden weight gain or swelling in legs and feet
- Blurred vision or eye pain
If experiencing severe symptoms, call emergency services immediately.
What is biosulin 30/70 100iu/ml cartridge used for?
This medicine is a premixed insulin injection containing 70% intermediate-acting and 30% short-acting human insulin. It is used to control blood sugar in diabetes and is injected under the skin, usually twice daily before meals.
- Generic Name: Insulin Isophane/NPH (70%) + Human Insulin/Soluble Insulin (30%)
- Manufacturer: Innova Life Sciences Private Limited
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 biosulin 30/70 100iu/ml cartridge के बारे में (Hindi Summary)
उपयोग: यह दवा मधुमेह (डायबिटीज) के इलाज के लिए इस्तेमाल की जाती है। इसमें 70% इंटरमीडिएट-एक्टिंग और 30% शॉर्ट-एक्टिंग इंसुलिन होता है, जो खाने के बाद और उसके बीच में ब्लड शुगर को कंट्रोल करता है। यह टाइप 1 और टाइप 2 डायबिटीज वाले मरीजों के लिए है, खासकर जब ओरल दवाएं काम नहीं कर रही हों। इसे त्वचा के नीचे इंजेक्शन के रूप में लगाया जाता है, आमतौर पर नाश्ते और रात के खाने से 30 मिनट पहले।
साइड इफेक्ट्स: सबसे आम साइड इफेक्ट है लो ब्लड शुगर (हाइपोग्लाइसीमिया), जिसमें पसीना आना, कंपकंपी, भूख लगना और घबराहट हो सकती है। इंजेक्शन लगाने की जगह पर लालिमा, सूजन या गांठ बन सकती है। कभी-कभी एलर्जी, वजन बढ़ना या पैरों में सूजन हो सकती है। गंभीर एलर्जी बहुत कम होती है, लेकिन अगर सांस लेने में तकलीफ हो तो तुरंत डॉक्टर को दिखाएं।
सुरक्षा सलाह: इंसुलिन लगाने से पहले और बाद में ब्लड शुगर जरूर चेक करें। हाइपोग्लाइसीमिया से बचने के लिए हमेशा ग्लूकोज की गोलियां या मीठा साथ रखें। इंजेक्शन की जगह बदल-बदल कर लगाएं। इंसुलिन को फ्रिज में रखें, लेकिन इस्तेमाल वाली पेन को कमरे के तापमान पर रखें। किसी और के साथ सुई या पेन शेयर न करें। शराब से बचें क्योंकि इससे शुगर अचानक गिर सकती है। डॉक्टर की सलाह के बिना डोज न बदलें।
💊 biosulin 30/70 100iu/ml cartridge Uses & Benefits
[{"condition":"Type 1 Diabetes Mellitus","description":"Used as part of a basal-bolus regimen to control blood glucose throughout the day and after meals.","evidence":"Well-established"},{"condition":"Type 2 Diabetes Mellitus","description":"Prescribed when oral antidiabetic drugs and lifestyle measures fail to achieve target HbA1c.","evidence":"Well-established"},{"condition":"Gestational Diabetes","description":"Used when diet and metformin are insufficient to control blood sugar during pregnancy.","evidence":"Well-established"},{"condition":"Diabetic Ketoacidosis (maintenance)","description":"May be used after initial intravenous insulin therapy to maintain glucose control.","evidence":"Established"}]
Off-label uses: [{"condition":"Hyperkalemia","description":"Sometimes used with glucose to shift potassium into cells in emergency settings.","evidence":"Limited"}]
Primary treatment for: Diabetes Mellitus
Also treats: Type 1 Diabetes, Type 2 Diabetes, Gestational Diabetes
📋 Drug Information
| Generic Name(s) | Insulin Isophane/NPH (70%) + Human Insulin/Soluble Insulin (30%) |
| Brand Name | biosulin 30/70 100iu/ml cartridge |
| Manufacturer | Innova Life Sciences Private Limited |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI DIABETIC |
| Action Class | |
| Route of Administration | Subcutaneous injection only. Never administer intravenously or intramuscularly |
| Storage | Store unopened vials in the refrigerator between 2°C and 8°C. Do not freeze. In-use vials or pens can be kept at room temperature (below 30°C) for up to 28 days, away from direct heat and light. Discard any unused insulin after 28 days. |
| Shelf Life | 24 months from the date of manufacture when stored under refrigeration. Once in use, discard after 28 days. |
| WHO Guideline | The World Health Organization includes human insulins in its Model List of Essential Medicines for the treatment of diabetes. Premixed insulins are recommended for use in settings where basal-bolus regimens are not feasible. |
| ICMR Guideline | The Indian Council of Medical Research guidelines recommend individualized insulin therapy for diabetes management, with premixed insulins as an option for patients with poor adherence to multiple daily injections. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by binding to insulin receptors on the surface of muscle and fat cells, as well as on liver cells. This binding activates a cascade of intracellular signals that increase glucose uptake into tissues and reduce glucose production by the liver. The soluble insulin component acts rapidly to lower post-meal blood sugar, while the isophane component forms a depot under the skin that releases insulin slowly over many hours. Together, they mimic the body's natural insulin profile.
Mechanism Steps
💡 How to Take biosulin 30/70 100iu/ml cartridge
Strength: Suspension for injection, 100 IU/mL. Available in vials and prefilled pens.
Dosage Information
| Adult Dosage | The dose of this medicine is highly individualized and must be determined by a qualified clinician based on your blood glucose levels, diet, physical activity, and other medications. It is typically injected subcutaneously 30 minutes before breakfast and dinner. The starting dose may be 0.3-0.5 IU/kg/day, but adjustments are made based on response. Never change your dose without consulting your doctor. |
| Pediatric Dosage | Pediatric dosing is individualized and must be determined by a pediatric endocrinologist based on weight, pubertal status, and glucose control. It is not established from available information for general use. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to insulin and have an increased risk of hypoglycemia. Doses should be individualized and started lower, with careful monitoring of blood glucose. Renal function decline with age may also affect insulin requirements. |
| Renal Impairment | In renal impairment, insulin requirements may be reduced due to decreased clearance. Dose should be individualized and blood glucose monitored closely. Consult your doctor for dose adjustment. |
| Hepatic Impairment | In hepatic impairment, insulin metabolism may be slowed, increasing the risk of hypoglycemia. Dose reduction may be necessary. Monitor blood glucose frequently and adjust as advised by your doctor. |
| Maximum Daily Dose | There is no fixed maximum daily dose; it is determined by individual needs. Doses are titrated to achieve target blood glucose levels. Always follow your doctor's prescription. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of biosulin 30/70 100iu/ml cartridge
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Metformin | Moderate | |
| Glimepiride | Major | |
| Prednisolone | Major | |
| Propranolol | Major | |
| Lisinopril | Moderate | |
| Hydrochlorothiazide | Moderate | |
| Levothyroxine | Moderate | |
| Warfarin | Minor | |
| Aspirin | Minor | |
| Alcohol | Major |
🚨 Major Interactions
- Oral antidiabetic drugs
- Beta-blockers
- Corticosteroids
- Thiazide diuretics
⚡ Moderate Interactions
- ACE inhibitors
- Alcohol
- Thyroid hormones
🍷 Alcohol Interaction
Alcohol can cause unpredictable changes in blood sugar, increasing the risk of severe hypoglycemia, especially if consumed without food. It may also mask symptoms of low blood sugar. Limit alcohol intake and always eat when drinking. Monitor blood glucose more frequently.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to human insulin or any excipient","Hypoglycemia (current episode)","Intravenous administration","Use in insulin pumps for this specific formulation"]
⚠️ Warnings & Precautions
["Hypoglycemia is the most common and serious risk; educate patients on recognition and management.","Do not change insulin brand or type without medical supervision.","Alcohol may increase hypoglycemia risk.","Illness, stress, or surgery may increase insulin requirements.","Renal or hepatic impairment may reduce insulin requirements.","Injection site rotation is essential to prevent lipodystrophy.","Never share insulin pens or needles.","Monitor blood glucose closely when traveling across time zones."]
🤱 Lactation Safety
Insulin is safe during breastfeeding. It is a large protein and is not excreted in breast milk in significant amounts. However, maternal blood glucose should be monitored as insulin requirements may change.
💊 Overdose Management
Overdose causes hypoglycemia. Mild hypoglycemia should be treated with oral glucose. Severe hypoglycemia with unconsciousness requires emergency medical help, glucagon injection, or intravenous glucose. Hospitalization may be needed for monitoring and intravenous dextrose infusion.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember if it is within 1-2 hours of the scheduled time. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose. Monitor blood glucose closely and consult your doctor if unsure.
Additional Safety Advice
Always check your blood sugar before injecting and carry a fast-acting sugar source in case of hypoglycemia. Rotate injection sites within the same area to prevent lipodystrophy. Never share your insulin pen or needles with anyone, even family members. Store unopened vials in the refrigerator and in-use pens at room temperature away from direct heat. Do not use this medicine if it looks cloudy or has particles after gentle mixing. Inform your doctor about all other medicines, especially those that affect blood sugar. Avoid driving or operating heavy machinery if you feel hypoglycemic. Wear a medical alert bracelet stating you have diabetes and use insulin.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of hypoglycemia due to reduced renal function, cognitive impairment, and polypharmacy. Doses should be started lower and titrated slowly. Regular monitoring of blood glucose and kidney function is essential. Simplify the regimen if possible to improve adherence.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor to optimize blood sugar control before conception. Good glycemic control reduces the risk of birth defects and complications. Insulin requirements may change during pregnancy, so frequent monitoring and dose adjustments are needed. This medicine is considered safe during pregnancy.
🏥 Post-Surgery Considerations
After surgery, blood sugar levels can be unpredictable due to stress and changes in diet. Insulin requirements may increase. Close monitoring of blood glucose is essential. Your doctor will adjust your insulin dose accordingly. Follow your surgical team's instructions regarding insulin use.
🦷 Dental Procedures
Inform your dentist that you have diabetes and are using insulin. Dental procedures can affect blood sugar due to stress and changes in eating. Monitor your blood glucose before and after the procedure. Take your insulin as prescribed unless advised otherwise by your doctor.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Exercise can lower blood sugar and increase the risk of hypoglycemia. Check your blood sugar before exercising. If it is below 100 mg/dL, eat a carbohydrate snack first. Carry fast-acting sugar during exercise. Adjust insulin dose as advised by your doctor. Avoid exercising if you have ketones in your urine.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may affect your ability to drive or operate machinery if you experience hypoglycemia. Always check your blood sugar before driving. Keep a fast-acting sugar source in your car. Inform your employer about your condition in case of emergencies. With proper management, most people can continue their normal work and daily activities.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Stopping insulin suddenly can lead to dangerous high blood sugar and diabetic ketoacidosis. If you experience severe side effects or your blood sugar is consistently low, contact your doctor for dose adjustment. Your doctor will guide you on any changes.
📅 Long-Term Use Effects
Long-term use of this medicine is generally safe and effective for managing diabetes. However, it can cause weight gain and increase the risk of hypoglycemia. Regular monitoring of blood glucose, HbA1c, and kidney function is important. Over time, insulin requirements may change due to changes in lifestyle, weight, or other health conditions. Regular follow-up with your doctor is essential.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Continuous subcutaneous insulin infusion using a pump can provide more flexible dosing.
Evidence: Well-establishedInsulins like glargine or degludec provide a flatter, more predictable basal insulin profile.
Evidence: Well-establishedMay be used in combination with insulin or alone in type 2 diabetes.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Vaccinations are generally safe for people with diabetes. However, illness or fever can affect blood sugar levels. Monitor your blood glucose more frequently after vaccination and adjust insulin as needed. Consult your doctor if you have concerns.
📦 Storage Guide
✅ DO
Store unopened vials in the refrigerator between 2°C and 8°C.
❌ DON'T
Do not freeze insulin or store it near the freezer compartment.
✅ DO
Keep in-use pens at room temperature below 30°C for up to 28 days.
❌ DON'T
Do not leave insulin in direct sunlight or hot places like a car.
✅ DO
Keep insulin in its original carton to protect from light.
❌ DON'T
Do not transfer insulin to unmarked containers.
✅ DO
Discard any unused insulin after 28 days of use.
❌ DON'T
Do not use insulin that looks cloudy or has particles after mixing.
✈️ Traveling with This Medicine
Carry your insulin in its original packaging with a prescription copy. Keep it in a cool bag or refrigerator during travel. For air travel, keep it in your carry-on luggage, not checked baggage. Adjust injection times gradually when crossing time zones, and monitor blood glucose more frequently. Check customs regulations for carrying medical supplies.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: The soluble component starts working within 30 minutes, while the isophane component takes longer to peak. The full effect lasts 12-18 hours.
A: Insulin is considered safe during pregnancy when clinically indicated. However, your dose may need adjustment. Consult your doctor.
A: If you remember within 2 hours, take the missed dose. If more than 2 hours have passed, skip it and continue with your regular schedule. Do not double dose.
A: Alcohol can cause unpredictable blood sugar changes and increase the risk of severe hypoglycemia. It is best to avoid or limit alcohol and always eat when drinking.
A: Store unopened vials in the refrigerator (2°C to 8°C). In-use pens can be kept at room temperature (below 30°C) for up to 28 days. Do not freeze.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: Insulin is addictive.
Fact: Insulin is a natural hormone that your body needs. It is not addictive; it is essential for life in people with type 1 diabetes. - Myth: Taking insulin means your diabetes is very severe.
Fact: Insulin is simply one of many treatment options. It is used when other medications are not enough to control blood sugar. - Myth: You can stop insulin once your blood sugar is normal.
Fact: Blood sugar is normal because of insulin. Stopping it without medical advice can cause dangerous high blood sugar. - Myth: Insulin causes blindness or kidney failure.
Fact: Poorly controlled diabetes causes these complications, not insulin. Insulin helps prevent them.
🔄 Alternative Options
Generic Alternatives
- Human insulin isophane/NPH 70% + human insulin soluble 30% (various manufacturers)
Brand Alternatives
- Human Mixtard 70/30
- Huminsulin 30/70
- Insugen 30/70
- Wosulin 30/70