biosone p eye/ear drops - Chloramphenicol (0.5%) + Dexamethasone (5000IU) medicine

Biosone P Eye/Ear Drops - Uses, Price, Side Effects

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๐Ÿญ Nri Vision Care India Limited ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Jun 29, 2026
๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
SaathiMed Expert Panel | Jun 29, 2026

What is biosone p eye/ear drops used for?

Biosone P Eye/Ear Drops combine Chloramphenicol (0.5%), an antibiotic, and Dexamethasone (5000IU), a corticosteroid. It treats bacterial infections with inflammation in the eyes and ears by killing bacteria and reducing swelling.

  • Generic Name: Chloramphenicol + Dexamethasone
  • Manufacturer: Nri Vision Care India Limited
  • Form: Allopathy
  • Pregnancy Category: C
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

๐Ÿ’Š biosone p eye/ear drops Uses & Benefits

Treatment of bacterial eye infections with inflammation (e.g., conjunctivitis, blepharitis)

Off-label uses: Prophylaxis after ocular surgery

๐Ÿ“‹ Drug Information

Generic Name(s)Chloramphenicol + Dexamethasone
Brand NameAnchlor-DX Eye Ointment
ManufacturerNri Vision Care India Limited
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassOPHTHAL
Action ClassAntibiotic + Corticosteroid
Route of AdministrationOphthalmic (topical)
StorageStore at 15-30ยฐC; protect from light; keep tightly closed
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionMinimal systemic absorption after ophthalmic application
DistributionLocal distribution in ocular tissues; negligible systemic distribution
Protein BindingChloramphenicol: 50-60%; Dexamethasone: 70-80%
MetabolismChloramphenicol: Hepatic via glucuronidation; Dexamethasone: Hepatic
Half-LifeChloramphenicol: 1.5-4 hours; Dexamethasone: 3-4 hours
ExcretionChloramphenicol: Renal (90% as inactive metabolites); Dexamethasone: Renal
BioavailabilityLow systemic bioavailability due to topical ophthalmic route
Onset of ActionWithin 24-48 hours
Peak Plasma TimeNot applicable (topical); local effect within hours
Duration of Action6-8 hours

How It Works

Chloramphenicol inhibits bacterial protein synthesis by binding to 50S ribosomal subunit; Dexamethasone suppresses inflammation by inhibiting phospholipase A2 and reducing prostaglandin synthesis

Mechanism Steps

1Chloramphenicol binds to 50S ribosomal subunit of bacteria, inhibiting peptide bond formation and protein synthesis
2Dexamethasone binds to glucocorticoid receptors, inducing lipocortin synthesis which inhibits phospholipase A2
3Inhibition of phospholipase A2 reduces arachidonic acid release, decreasing prostaglandin and leukotriene synthesis

๐Ÿ’ก How to Take biosone p eye/ear drops

Follow your doctor's prescription exactly.

Dosage Timeline

๐ŸŒ… Morning โœ… โ˜€๏ธ Afternoon โŒ ๐ŸŒ† Evening โœ… ๐ŸŒ™ Night โŒ

โš ๏ธ Side Effects of biosone p eye/ear drops

โœ… Common Side Effects

  • Burning
  • Stinging
  • Blurred vision
  • Eye irritation

๐Ÿšจ Serious Side Effects

  • Bone marrow suppression (aplastic anemia) with prolonged systemic use
  • Increased intraocular pressure
  • Cataract formation

โš ๏ธ Rare Side Effects

  • Hypersensitivity reactions
  • Superinfection
  • Delayed wound healing

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
Warfarin Major Increased bleeding risk
Phenytoin Moderate Decreased phenytoin metabolism
Live vaccines Major Reduced vaccine efficacy

๐Ÿšจ Major Interactions

  • Warfarin
  • Phenytoin
  • Phenobarbital
  • Rifampin

โšก Moderate Interactions

  • Oral contraceptives
  • Antidiabetic agents
  • Cyclosporine

โ„น๏ธ Minor Interactions

  • Antacids
  • Cimetidine

๐Ÿฝ๏ธ Food Interactions

No significant food interactions

๐Ÿท Alcohol Interaction

No known interaction

๐Ÿ›ก๏ธ Safety & Warnings

Liver
Low
Kidney
Low
Heart
Low
Pregnancy
Category C

๐Ÿšซ Contraindications

Hypersensitivity to chloramphenicol, dexamethasone, or any component; viral, fungal, or mycobacterial eye infections; untreated eye infections

๐Ÿ“Š Monitoring Parameters

Clinical response; intraocular pressure if prolonged use; signs of secondary infection

๐Ÿคฑ Lactation Safety

Caution; small amounts may be excreted in breast milk

๐Ÿ’Š Overdose Management

Unlikely with topical use; if ingested, symptomatic treatment

โฐ Missed Dose

Apply as soon as remembered; skip if almost time for next dose; do not double

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Reviewed: Jun 29, 2026

๐Ÿ”— View Profile

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