Azukon M Tablet: Comprehensive Guide to Uses, Side Effects, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain that radiates to the back
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Confusion, seizures, or unconsciousness
If experiencing severe symptoms, call emergency services immediately.
What is bioformin forte 80 mg/500 mg tablet used for?
This medicine is a combination of gliclazide and metformin used to treat type 2 diabetes. It lowers blood sugar by increasing insulin release and improving insulin sensitivity. It should be taken with meals and requires regular monitoring.
- Generic Name: Gliclazide + Metformin
- Manufacturer: Biological E Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 bioformin forte 80 mg/500 mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा ग्लिक्लाजाइड और मेटफॉर्मिन का संयोजन है, जिसका उपयोग टाइप 2 डायबिटीज (मधुमेह) के इलाज के लिए किया जाता है। यह रक्त शर्करा को कम करने में मदद करती है। ग्लिक्लाजाइड अग्न्याशय से इंसुलिन निकालने को बढ़ावा देता है, जबकि मेटफॉर्मिन शरीर में इंसुलिन की कार्यक्षमता को बेहतर बनाता है और लीवर में शर्करा बनने को कम करता है। यह दवा उन वयस्कों के लिए है जिनका मधुमेह आहार, व्यायाम और एक दवा से नियंत्रित नहीं हो रहा है। इसे भोजन के साथ लेना चाहिए। इसका सेवन डॉक्टर की सलाह के अनुसार ही करें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में कम रक्त शर्करा (हाइपोग्लाइसीमिया), जी मिचलाना, दस्त, पेट में गड़बड़ी और मुँह में धातु जैसा स्वाद शामिल हैं। गंभीर लेकिन दुर्लभ दुष्प्रभावों में लैक्टिक एसिडोसिस, गंभीर हाइपोग्लाइसीमिया, रक्त विकार, अग्न्याशय की सूजन और गंभीर एलर्जी प्रतिक्रिया शामिल हैं। यदि आपको मांसपेशियों में दर्द, सांस लेने में कठिनाई, पेट में तेज दर्द, या बेहोशी जैसे लक्षण दिखें तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को हमेशा भोजन के साथ लें ताकि पेट की गड़बड़ी और कम रक्त शर्करा का खतरा कम हो। इस दवा को लेते समय भोजन न छोड़ें। शराब का सेवन न करें क्योंकि इससे लैक्टिक एसिडोसिस और हाइपोग्लाइसीमिया का खतरा बढ़ सकता है। अपने डॉक्टर को किडनी या लीवर की समस्या के बारे में बताएं। बिना डॉक्टर की सलाह के दवा बंद या डोज न बदलें। नियमित रूप से ब्लड शुगर और किडनी फंक्शन की जांच कराएं।
💊 bioformin forte 80 mg/500 mg tablet Uses & Benefits
[{"condition":"Type 2 diabetes mellitus","description":"Used as an add-on or combination therapy to improve blood sugar control in adults whose diabetes is not controlled by diet, exercise, and a single oral agent.","evidence":"Well-established"},{"condition":"Type 2 diabetes with insulin resistance","description":"Metformin improves insulin sensitivity, while gliclazide increases insulin secretion, making this combination useful in patients with insulin resistance.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Polycystic ovary syndrome (PCOS)","description":"Metformin alone is sometimes used off-label in PCOS to improve insulin resistance and menstrual regularity, but the combination with gliclazide is not standard for this use.","evidence":"Limited"}]
Primary treatment for: Type 2 diabetes mellitus
Also treats: Insulin resistance, Metabolic syndrome
📋 Drug Information
| Generic Name(s) | Gliclazide + Metformin |
| Brand Name | Azukon-M Tablet |
| Manufacturer | Biological E Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI DIABETIC |
| Action Class | Sulfonylurea + Biguanide |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C, away from direct sunlight and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two antidiabetic agents with complementary mechanisms. Gliclazide binds to sulfonylurea receptors on pancreatic beta cells, closing ATP-sensitive potassium channels, which leads to membrane depolarization, calcium influx, and increased insulin release. Metformin decreases hepatic glucose production, reduces intestinal glucose absorption, and improves peripheral insulin sensitivity by activating AMP-activated protein kinase (AMPK). Together, they lower blood glucose levels by increasing insulin supply and improving insulin action.
Mechanism Steps
💡 How to Take bioformin forte 80 mg/500 mg tablet
Strength: Each tablet contains Gliclazide 80 mg and Metformin 500 mg.
Dosage Information
| Adult Dosage | The usual starting dose of this medicine is one tablet taken once or twice daily with meals. The dose may be adjusted by your doctor based on your blood sugar levels, kidney function, and overall health. The maximum daily dose is generally 2 tablets (gliclazide 160 mg and metformin 1000 mg) per day, but this may vary. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine, especially the risk of hypoglycemia and lactic acidosis. Start with a lower dose and monitor kidney function closely. Dose must be individualized by a qualified clinician. |
| Renal Impairment | This medicine is contraindicated in patients with severe kidney impairment (eGFR <30 mL/min/1.73 m²). In patients with mild to moderate kidney impairment, dose adjustment or discontinuation may be necessary. Regular monitoring of kidney function is essential. Dose must be individualized by a qualified clinician. |
| Hepatic Impairment | This medicine should be used with caution in patients with liver disease. In severe liver disease, it is contraindicated. Dose adjustment may be needed based on liver function. Dose must be individualized by a qualified clinician. |
| Maximum Daily Dose | The maximum daily dose is generally 2 tablets (gliclazide 160 mg and metformin 1000 mg) per day, but this may vary based on individual patient factors. Do not exceed the dose prescribed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of bioformin forte 80 mg/500 mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Contrast media | Major | |
| Alcohol | Major | |
| Insulin | Major | |
| Beta-blockers | Moderate | |
| Diuretics | Moderate | |
| Corticosteroids | Moderate | |
| ACE inhibitors | Moderate | |
| Cimetidine | Minor | |
| Rifampicin | Minor | |
| Warfarin | Moderate |
🚨 Major Interactions
- Contrast media (iodinated)
- Alcohol
- Other sulfonylureas or insulin
⚡ Moderate Interactions
- Beta-blockers
- Diuretics (thiazides, loop)
- Corticosteroids
- ACE inhibitors
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine because it increases the risk of lactic acidosis and can cause dangerous drops in blood sugar. It can also worsen liver and kidney function, which are important for the safe use of this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Type 1 diabetes mellitus","Diabetic ketoacidosis","Severe kidney impairment (eGFR
⚠️ Warnings & Precautions
["Risk of lactic acidosis with metformin, especially in patients with kidney or liver disease, dehydration, or alcohol use.","Hypoglycemia can occur, particularly with skipped meals, alcohol, or intense exercise.","Temporarily discontinue before surgery or procedures using iodinated contrast media.","Use with caution in elderly patients and those with adrenal or pituitary insufficiency.","May cause vitamin B12 deficiency with long-term use; monitor levels.","Avoid in patients with severe kidney impairment.","Do not use in pregnancy or breastfeeding unless clearly needed and under medical supervision."]
🤱 Lactation Safety
This medicine is not recommended during breastfeeding because it may pass into breast milk and cause low blood sugar in the infant. Consult your doctor for alternative treatments.
💊 Overdose Management
Overdose can cause severe hypoglycemia and lactic acidosis. Symptoms include shakiness, sweating, confusion, rapid heartbeat, and in severe cases, unconsciousness. If overdose is suspected, seek emergency medical help immediately. Treatment may include intravenous glucose for hypoglycemia and supportive care for lactic acidosis, including dialysis if necessary.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember, provided it is not almost time for your next dose. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Always take this medicine with meals to lower the chance of stomach upset and low blood sugar. Never skip meals while on this medicine, especially if you are taking other diabetes medicines or exercising more than usual. Check your blood sugar regularly as advised by your doctor. Avoid alcohol because it can increase the risk of lactic acidosis and low blood sugar. Tell your doctor if you have kidney or liver problems, as the dose may need to be adjusted or the medicine may not be suitable for you. Do not stop or change the dose without talking to your doctor first. Carry a source of fast-acting sugar, such as glucose tablets or candy, in case of low blood sugar. Inform your doctor before any surgery, scan with contrast dye, or dental procedure. Keep all follow-up appointments for blood tests, including kidney function and vitamin B12 levels.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more prone to hypoglycemia and lactic acidosis. Start with a lower dose and monitor kidney function closely. Regular blood sugar monitoring and education about hypoglycemia symptoms are essential.
🤰 Pregnancy Planning (TTC)
This medicine is not recommended during pregnancy. If you are planning pregnancy, consult your doctor to switch to a safer alternative, usually insulin. Good blood sugar control before and during pregnancy is crucial for the health of both mother and baby.
🏥 Post-Surgery Considerations
This medicine may need to be temporarily stopped before surgery, especially if you will be fasting or if contrast dyes are used. Follow your doctor's instructions. Blood sugar levels should be monitored closely during the perioperative period.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine. If you are having a procedure that requires fasting or sedation, your doctor may adjust your dose. Maintain good oral hygiene and monitor blood sugar as dental infections can affect glucose control.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Exercise can lower blood sugar and increase the risk of hypoglycemia, especially if you take this medicine. Check your blood sugar before exercising and carry a source of fast-acting sugar. Avoid intense exercise if your blood sugar is very low or very high. Stay hydrated and consult your doctor before starting a new exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause low blood sugar, which can affect your ability to drive or operate machinery. Be cautious until you know how the medicine affects you. Keep a source of sugar with you at all times. Inform your employer about your condition if your job involves safety-sensitive tasks. Regular meals and monitoring can help you manage your work routine safely.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience severe side effects such as lactic acidosis, severe hypoglycemia, or allergic reactions, seek immediate medical attention. Your doctor may stop the medicine temporarily before surgery or contrast procedures. Always follow your doctor's guidance on when and how to stop.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to vitamin B12 deficiency, which can cause anemia and nerve problems. Regular monitoring of vitamin B12 levels is advised. Kidney function should be checked at least annually, as metformin can accumulate in kidney impairment. Blood sugar control should be assessed with HbA1c every 3-6 months. The dose may need adjustment over time based on changes in kidney function, other medications, and overall health.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Diet and exercise are the cornerstone of diabetes management and can reduce the need for medication.
Evidence: Well-establishedDPP-4 inhibitors, SGLT2 inhibitors, or GLP-1 receptor agonists may be alternatives based on individual needs.
Evidence: Well-establishedMay be required if oral agents fail to control blood sugar.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
People with diabetes are at higher risk of infections. Ensure you are up to date with vaccinations, including influenza, pneumococcal, and hepatitis B vaccines. Consult your doctor about the best timing for vaccinations.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss or temperature extremes. If crossing time zones, consult your doctor about adjusting the timing of doses to maintain blood sugar control. Store at room temperature and avoid leaving it in hot cars or direct sunlight. Check customs regulations for carrying prescription medicines to your destination.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts lowering blood sugar within 1-2 hours, but the full effect on overall glucose control may take several days to weeks. Regular monitoring will show the benefit.
A: It depends on the severity of kidney impairment. This medicine is contraindicated in severe kidney disease. Your doctor will monitor your kidney function and adjust the dose or choose an alternative if needed.
A: If you feel shaky, sweaty, or confused, eat or drink something sugary immediately, such as glucose tablets, candy, or fruit juice. If symptoms persist or you become unconscious, seek emergency medical help.
A: No, do not stop taking this medicine without consulting your doctor. Diabetes is a chronic condition, and stopping treatment can cause blood sugar to rise again.
🤔 Common Patient Concerns
🔄 Substitutes for bioformin forte 80 mg/500 mg tablet
View AllAlternative brands with exact same active ingredient:
-
bioformin 80mg/500mg tabletBiogenetic Pharmaceuticals ₹7.03 56.9% CHEAPER
-
bioformin plus 80 mg/500 mg tabletBiological E Ltd ₹10.29 36.9% CHEAPER
-
micromol p tabletSouthshourne Corporation India ₹11.25 31% CHEAPER
-
metbetic g tabletCadila Pharmaceuticals Ltd ₹13.29 18.5% CHEAPER
-
cyzide m 80mg/500mg tabletCyper Drugs & Pharmaceuticals Pvt Ltd ₹15.19 6.9% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure diabetes.
Fact: This medicine helps control blood sugar but does not cure diabetes. It must be continued as prescribed along with lifestyle changes. - Myth: You can eat anything while taking this medicine.
Fact: A healthy diet and regular exercise are essential for managing diabetes. This medicine works best when combined with lifestyle modifications. - Myth: This medicine is safe for everyone with diabetes.
Fact: It is not suitable for people with type 1 diabetes, severe kidney or liver disease, or during pregnancy and breastfeeding.
🔄 Alternative Options
Generic Alternatives
- Gliclazide 80 mg + Metformin 500 mg tablet (various manufacturers)
Brand Alternatives
- Azukon M Tablet
- Diamicron XR M Tablet
- Glycinorm M Tablet
- Glimestar M Tablet