Bio Migron 10mg/5mg/325mg Tablet - Uses, Price, Side Effects
What is bio migron 10mg/5mg/325mg tablet used for?
Bio Migron 10mg/5mg/325mg Tablet is a combination of Domperidone and Flunarizine used to prevent migraine and relieve nausea. Domperidone blocks dopamine receptors to reduce nausea, while Flunarizine inhibits calcium channels to prevent migraine attacks. It is taken twice daily as prescribed.
- Generic Name: Domperidone + Flunarizine
- Manufacturer: Advok Pharmacia Private Limited
- Form: Allopathy
- Pregnancy Category: C
- Prescription Required: Yes
๐ bio migron 10mg/5mg/325mg tablet Uses & Benefits
๐ Drug Information
| Generic Name(s) | Domperidone + Flunarizine |
| Brand Name | Blomig P 10 mg/5 mg/325 mg Tablet |
| Manufacturer | Advok Pharmacia Private Limited |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | Antiemetic + Calcium Channel Blocker |
| Route of Administration | Oral |
| Storage | Store at 20-25ยฐC, protect from light and moisture. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Domperidone blocks dopamine D2 receptors in the chemoreceptor trigger zone and gastrointestinal tract; Flunarizine blocks calcium channels and histamine H1 receptors, preventing vasoconstriction and vestibular stimulation.
Mechanism Steps
๐ก How to Take bio migron 10mg/5mg/325mg tablet
Follow your doctor's prescription exactly.
Dosage Timeline
โ ๏ธ Side Effects of bio migron 10mg/5mg/325mg tablet
โ Common Side Effects
- Drowsiness
- Dry mouth
- Weight gain
- Fatigue
๐จ Serious Side Effects
- QT prolongation
- Tardive dyskinesia
- Extrapyramidal symptoms
- Depression
โ ๏ธ Rare Side Effects
- Galactorrhea
- Gynecomastia
- Parkinsonism
- Neuroleptic malignant syndrome
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| CYP2D6 inhibitors | Moderate | Increased domperidone levels |
| CYP3A4 inhibitors | Moderate | Increased flunarizine levels |
| Anticholinergics | Minor | Reduced gastrointestinal motility |
๐จ Major Interactions
- CYP3A4 inhibitors (e.g., ketoconazole)
- QT-prolonging drugs (e.g., amiodarone)
- MAOIs
โก Moderate Interactions
- Anticholinergics
- CNS depressants
- Antihypertensives
โน๏ธ Minor Interactions
- Antacids
- H2 antagonists
๐ฝ๏ธ Food Interactions
Grapefruit juice may increase domperidone levels; high-fat meals may reduce absorption.
๐ท Alcohol Interaction
Increased CNS depression and dizziness
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity, GI hemorrhage, prolactinoma, QT prolongation, severe hepatic impairment
๐ Monitoring Parameters
ECG for QT interval, liver function tests, serum prolactin
๐คฑ Lactation Safety
Not recommended; domperidone excreted in breast milk, flunarizine unknown.
๐ Overdose Management
Symptomatic and supportive; ECG monitoring for QT prolongation; activated charcoal if recent ingestion.
โฐ Missed Dose
Take as soon as remembered unless near next dose; skip missed dose if close to next.