bilbil-m tablet - Bilastine (20mg) + Montelukast (10mg) medicine

Bilasure M 20mg/10mg Tablet: Complete Medicine Guide

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🏭 Sherim Squibss 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 21, 2026
⚠️ Hepatotoxicity Risk 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Moderate to well-established for allergic rhinitis and chronic urticaria.
Reviewed by
SaathiMed Expert Panel | Sep 21, 2026

When to Call Your Doctor IMMEDIATELY

  • Sudden swelling of the face, lips, or throat
  • Difficulty breathing or wheezing that worsens
  • Severe skin rash or hives covering the body
  • Yellowing of the skin or eyes (jaundice)
  • Severe abdominal pain or dark urine
  • Unusual bruising or bleeding
  • Mood changes, confusion, or suicidal thoughts

If experiencing severe symptoms, call emergency services immediately.

What is bilbil-m tablet used for?

This medicine is a combination of bilastine (an antihistamine) and montelukast (a leukotriene receptor antagonist) used to treat allergic rhinitis and chronic urticaria. It works by blocking histamine and leukotriene pathways to reduce sneezing, itching, runny nose, and hives. It is taken once daily as prescribed by your doctor.

  • Generic Name: Bilastine (20mg) + Montelukast (10mg)
  • Manufacturer: Sherim Squibss
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 bilbil-m tablet के बारे में (Hindi Summary)

उपयोग: यह दवा बिलास्टीन और मॉन्टेलुकास्ट का संयोजन है, जिसका उपयोग एलर्जिक राइनाइटिस (नाक की एलर्जी) और पित्ती (चकत्ते) के इलाज के लिए किया जाता है। यह छींक, नाक बहना, खुजली और आंखों में पानी आने जैसे लक्षणों को कम करने में मदद करती है। यह दवा एलर्जी पैदा करने वाले हिस्टामिन और ल्यूकोट्रिन दोनों को रोककर काम करती है। इसे डॉक्टर की सलाह के अनुसार ही लें।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में सिरदर्द, नींद आना, थकान, मुंह सूखना और पेट में असहजता शामिल हैं। ये आमतौर पर हल्के होते हैं और अपने आप ठीक हो जाते हैं। कभी-कभी चक्कर आना, मतली या नींद में गड़बड़ी हो सकती है। दुर्लभ मामलों में मानसिक लक्षण जैसे चिड़चिड़ापन, अवसाद या आत्महत्या के विचार हो सकते हैं। अगर ऐसा कुछ हो तो तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। खुराक से ज्यादा न लें। जब तक आपको पता न चले कि यह दवा आप पर कैसा असर करती है, तब तक वाहन चलाने या मशीनरी चलाने से बचें। शराब का सेवन न करें क्योंकि इससे नींद और चक्कर बढ़ सकते हैं। अगर आप गर्भवती हैं, गर्भधारण की योजना बना रही हैं या स्तनपान करा रही हैं, तो डॉक्टर से सलाह लें। इस दवा को बच्चों की पहुंच से दूर रखें।

💡 Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

💊 bilbil-m tablet Uses & Benefits

[{"condition":"Seasonal allergic rhinitis","description":"Relieves sneezing, runny nose, itchy and watery eyes, and nasal congestion associated with seasonal pollen allergies.","evidence":"Well-established"},{"condition":"Perennial allergic rhinitis","description":"Provides year-round relief from nasal symptoms triggered by dust mites, pet dander, and mold spores.","evidence":"Well-established"},{"condition":"Chronic urticaria","description":"Reduces itching and hives in patients who do not achieve adequate control with antihistamines alone.","evidence":"Moderate"},{"condition":"Allergic asthma with rhinitis","description":"May help control both upper and lower airway allergic symptoms when used as add-on therapy.","evidence":"Limited"}]

Off-label uses: [{"condition":"Exercise-induced bronchoconstriction","description":"Montelukast component may be used off-label to prevent exercise-induced narrowing of airways.","evidence":"Limited"},{"condition":"Atopic dermatitis","description":"Occasionally prescribed off-label to reduce itching in allergic skin conditions.","evidence":"Limited"}]

Primary treatment for: Allergic rhinitis

Also treats: Chronic urticaria, Allergic asthma with rhinitis

📋 Drug Information

Generic Name(s)Bilastine (20mg) + Montelukast (10mg)
Brand Namebilbil-m tablet
ManufacturerSherim Squibss
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassRESPIRATORY
Action Class
Route of AdministrationOral
StorageStore at room temperature between 15°C and 30°C. Keep away from moisture and direct sunlight. Keep in the original container.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine at the same time each day to maintain consistent blood levels.
2
If you experience drowsiness, avoid driving or operating heavy machinery until you know how it affects you.
3
Do not use this medicine to treat an acute asthma attack; it is not a rescue inhaler.
4
Inform your doctor if you have a history of mental health conditions, as montelukast may rarely cause mood changes.
5
Avoid alcohol while taking this medicine to prevent increased drowsiness.
6
If you miss a dose, take it as soon as you remember, but do not double the dose.
7
Report any unusual bruising or bleeding to your doctor, especially if you are on blood thinners.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

Sneezing and runny nose
This medicine is commonly prescribed for allergic rhinitis.
Likely Use
Itchy hives
This medicine is used for chronic urticaria.
Likely Use
Fever
This medicine is not a primary fever reducer.
Not Primary
Acute asthma attack
This medicine is not a rescue medicine for acute asthma attacks.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionBilastine is rapidly absorbed after oral administration, reaching peak plasma concentrations within about 1.3 hours. Montelukast is also rapidly absorbed, with peak plasma levels occurring within 3 to 4 hours. Food does not significantly affect the absorption of either component.
DistributionBilastine has a volume of distribution of approximately 1.2 L/kg and is about 84% bound to plasma proteins. Montelukast is more than 99% bound to plasma proteins and has a volume of distribution of approximately 8 to 11 liters.
Protein BindingBilastine is approximately 84% bound to plasma proteins. Montelukast is more than 99% bound to plasma proteins.
MetabolismBilastine undergoes minimal metabolism and is primarily excreted unchanged. Montelukast is extensively metabolized in the liver by cytochrome P450 enzymes, mainly CYP2C8 and CYP3A4.
Half-LifeThe elimination half-life of bilastine is approximately 14.5 hours in healthy adults. The elimination half-life of montelukast is approximately 2.7 to 5.5 hours in healthy adults.
ExcretionBilastine is excreted mainly in the feces (about 67%) and urine (about 33%) as unchanged drug. Montelukast is excreted primarily in the bile and feces.
BioavailabilityThe oral bioavailability of bilastine is approximately 61%. The oral bioavailability of montelukast is approximately 64% when taken without food.
Onset of ActionBilastine begins to relieve allergic symptoms within 1 hour of oral administration. Montelukast may take several days to achieve full therapeutic effect for airway symptoms.
Peak Plasma TimeBilastine reaches peak plasma concentration in about 1.3 hours. Montelukast reaches peak plasma concentration in about 3 to 4 hours.
Duration of ActionBilastine provides antihistaminic effects for at least 24 hours, allowing once-daily dosing. Montelukast provides 24-hour control of leukotriene-mediated symptoms.

How It Works

This medicine combines two active ingredients with complementary mechanisms. Bilastine is a selective peripheral H1-receptor antagonist that prevents histamine from binding to H1 receptors on blood vessels and nerve endings, thereby reducing sneezing, itching, and vasodilation. Montelukast is a selective cysteinyl leukotriene receptor antagonist that blocks the CysLT1 receptor, preventing leukotriene D4 and E4 from causing bronchoconstriction, mucus secretion, and airway edema. Together, they address both histamine- and leukotriene-mediated allergic pathways.

Mechanism Steps

1
Histamine H1 receptor blockade: Bilastine binds selectively to peripheral H1 receptors, preventing histamine from triggering allergic symptoms such as sneezing, itching, and runny nose.
2
Leukotriene CysLT1 receptor blockade: Montelukast blocks CysLT1 receptors in the airways and other tissues, preventing leukotriene-mediated bronchoconstriction and inflammation.
3
Reduced allergic inflammation: By inhibiting both histamine and leukotriene pathways, this medicine decreases vascular permeability, mucus secretion, and inflammatory cell recruitment.
4
Symptom relief: The combined action leads to reduced nasal congestion, itching, sneezing, and hives, improving overall allergy control.

💡 How to Take bilbil-m tablet

Strength: Tablet containing bilastine 20 mg and montelukast 10 mg.

1Take this medicine orally with a glass of water.
2Swallow the tablet whole. Do not crush or chew it.
3Take it at the same time each day to maintain consistent levels.
4You may take it with or without food.
5If it causes stomach upset, take it with a meal or snack.

Dosage Information

Adult DosageThe usual adult dose of this medicine is one tablet (bilastine 20 mg + montelukast 10 mg) taken orally once daily, with or without food. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the recommended dose.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageNo specific dose adjustment is required for elderly patients with normal renal and hepatic function. However, use with caution due to potential increased sensitivity to side effects. Dose must be individualized by a qualified clinician.
Renal ImpairmentNo dose adjustment is required for mild to moderate renal impairment. In severe renal impairment, use with caution and consult your doctor for appropriate dosing.
Hepatic ImpairmentNo dose adjustment is required for mild to moderate hepatic impairment. This medicine is contraindicated in severe hepatic impairment.
Maximum Daily DoseOne tablet (bilastine 20 mg + montelukast 10 mg) once daily.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with or without food
Food does not significantly affect absorption.
Grapefruit juice
Avoid
May increase bilastine levels and side effects.
High-fat meals
Take with caution
May slightly delay montelukast absorption.

⏰ What to Do If You Miss a Dose

📌 Less than 12 hours have passed since the missed dose
→ Take the missed dose as soon as you remember.
💡 Continue with your regular schedule.
📌 More than 12 hours have passed since the missed dose
→ Skip the missed dose.
💡 Do not double dose to catch up. Take your next dose at the regular time.

⚠️ Side Effects of bilbil-m tablet

✅ Common Side Effects

Headache (Common (5-10%))
Usually resolves on its own. Consult your doctor if it persists or becomes severe.
Drowsiness (Common (5-10%))
Avoid driving or operating machinery until you know how this medicine affects you.
Fatigue (Common (5-10%))
Get adequate rest. If fatigue interferes with daily activities, consult your doctor.
Dry mouth (Common (5-10%))
Stay hydrated by drinking water regularly. Chewing sugar-free gum may help.
Abdominal discomfort (Common (5-10%))
Take this medicine with food to reduce stomach upset. Consult your doctor if pain persists.

🚨 Serious Side Effects

Neuropsychiatric events (agitation, depression, suicidal thoughts) (Rare (<0.1%))
Seek immediate medical attention if you experience mood changes, confusion, or suicidal thoughts.
Severe allergic reaction (anaphylaxis) (Rare (<0.1%))
Seek emergency medical help if you develop rash, swelling of face or throat, or difficulty breathing.
Liver injury (Rare (<0.1%))
Report yellowing of skin or eyes, dark urine, or severe abdominal pain to your doctor immediately.

⚠️ Rare Side Effects

Sleepwalking
Inform your doctor if this occurs. Dose adjustment or discontinuation may be needed.
Increased bleeding tendency
Report unusual bruising or bleeding to your doctor promptly.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major
Phenobarbital Major
Rifampicin Major
Gemfibrozil Moderate
Ketoconazole Moderate
Erythromycin Moderate
Antacids Minor
Cimetidine Minor

🚨 Major Interactions

  • Warfarin
  • Phenobarbital
  • Rifampicin

⚡ Moderate Interactions

  • Gemfibrozil
  • Ketoconazole
  • Erythromycin

🍷 Alcohol Interaction

Alcohol may increase the drowsiness and dizziness caused by this medicine. It is advisable to avoid alcohol while taking this medicine.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Hypersensitivity to bilastine or montelukast","Severe hepatic impairment","Children below the approved age for this combination","Acute asthma attacks (not a rescue medicine)"]

⚠️ Warnings & Precautions

["May cause drowsiness; avoid driving or operating machinery until you know how it affects you.","Neuropsychiatric events have been reported with montelukast. Seek medical attention if mood changes occur.","Do not use for acute asthma attacks.","Use with caution in patients with severe renal impairment.","Avoid alcohol while taking this medicine.","Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding."]

🤱 Lactation Safety

It is not known whether bilastine or montelukast are excreted in human breast milk. Consult your doctor before breastfeeding while taking this medicine.

💊 Overdose Management

There is no specific antidote for overdose with this medicine. If overdose is suspected, seek immediate medical attention. Treatment should be symptomatic and supportive. Monitor vital signs and provide appropriate care.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose. Avoid driving or operating heavy machinery until you know how this medicine affects you, as drowsiness may occur. Inform your doctor about all other medicines you are taking, especially pain relievers, blood thinners, and certain antibiotics. Avoid alcohol while taking this medicine because it can increase drowsiness. Do not use this medicine to treat an acute asthma attack. If you are pregnant, planning pregnancy, or breastfeeding, consult your doctor before using this medicine. Keep this medicine out of reach of children. Store it at room temperature away from moisture and direct sunlight.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients may be more sensitive to the side effects of this medicine, especially drowsiness and dizziness. Use with caution and monitor for falls. No specific dose adjustment is required for those with normal kidney and liver function.

🤰 Pregnancy Planning (TTC)

If you are planning pregnancy, consult your doctor before taking this medicine. The safety of this combination during pregnancy is not well established. Your doctor will weigh the benefits and risks.

🏥 Post-Surgery Considerations

Inform your surgeon and anesthesiologist that you are taking this medicine before any surgery. It may interact with other medications used during surgery. Your doctor may advise you to stop it temporarily.

🦷 Dental Procedures

Inform your dentist that you are taking this medicine before any dental procedure. It may cause dry mouth, which can affect dental health. Maintain good oral hygiene.

💚 Lifestyle Tips for Better Results

🏃
Identify and avoid allergy triggers such as pollen, dust mites, and pet dander.
🥗
Use air purifiers and keep windows closed during high pollen seasons.
😴
Maintain a healthy diet rich in fruits and vegetables to support immune health.
💧
Get adequate sleep to help your body recover.
🧘
Exercise regularly, but avoid outdoor activities during high pollen counts.
🌞
Keep your home clean and free of mold and dust.

🏋️ Exercise Considerations

This medicine may cause drowsiness or dizziness. Avoid strenuous exercise or activities that require alertness until you know how it affects you. If you experience dizziness, stop exercising and rest.

🥗 Diet Recommendations

Include omega-3 rich foods like fish and flaxseeds to reduce inflammation.
Avoid processed foods and excess sugar.
Stay well hydrated by drinking plenty of water.
Consume foods rich in vitamin C to support immune function.

💼 Impact on Daily Work & Life

This medicine may cause mild drowsiness, which can affect your ability to drive or operate machinery. It is advisable to avoid these activities until you know how the medicine affects you. Most people can continue their daily work activities with minimal disruption.

🛑 When to Stop This Medicine

Do not stop this medicine without consulting your doctor. If you experience serious side effects such as mood changes, allergic reactions, or liver problems, seek immediate medical attention. Your doctor will decide if and when to stop the medicine.

📅 Long-Term Use Effects

Long-term use of this medicine is generally well tolerated. However, montelukast has been associated with rare neuropsychiatric events. Regular monitoring of mood and behavior is advised. Liver function should be monitored if symptoms occur. Periodic review with your doctor is recommended to assess ongoing need and effectiveness.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Allergen avoidance

Identifying and avoiding allergens can reduce the need for medication.

Evidence: Well-established
Nasal saline irrigation

Rinsing the nasal passages with saline can help relieve nasal congestion.

Evidence: Well-established
Immunotherapy

Allergy shots or sublingual tablets can provide long-term relief for allergic rhinitis.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

This medicine does not interact with vaccines. You can receive vaccinations while taking this medicine. Consult your doctor for specific timing.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

When traveling, carry this medicine in its original packaging with a copy of your prescription. Store it at room temperature and protect it from moisture and direct sunlight. If crossing time zones, continue taking your dose at the same local time as usual. Check customs regulations for carrying prescription medicines in your destination country. Always carry enough supply for the entire trip.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 32-year-old woman with seasonal allergic rhinitis
She had tried several antihistamines with limited relief from sneezing and itchy eyes. Her doctor prescribed this medicine. Within a week, her symptoms improved significantly, and she could enjoy outdoor activities again. She noted mild drowsiness initially, which subsided after a few days.
💡 Lesson: Combination therapy can provide better symptom control for patients who do not respond to single agents. Mild side effects often diminish with continued use.
👤 A 45-year-old man with chronic urticaria
He suffered from persistent hives and itching that interfered with sleep. After starting this medicine, his hives reduced dramatically within two weeks. He was advised to avoid alcohol and to report any mood changes. He experienced no serious side effects.
💡 Lesson: This medicine can be effective for chronic urticaria when antihistamines alone are insufficient. Regular follow-up and monitoring for neuropsychiatric symptoms are important.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: Bilastine starts working within 1 hour, while montelukast may take a few days to show full effect. You may notice improvement in allergy symptoms within the first week.

Q: Can I take this medicine with food?

A: Yes, you can take this medicine with or without food. If it causes stomach upset, take it with a meal or snack.

Q: Is it safe to drive after taking this medicine?

A: This medicine may cause drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you.

Q: What should I do if I miss a dose?

A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.

Q: Can I drink alcohol while taking this medicine?

A: It is advisable to avoid alcohol as it may increase drowsiness and dizziness.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for bilbil-m tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can be used to treat acute asthma attacks.
    Fact: This medicine is not a rescue medicine for acute asthma attacks. It is used for long-term control of allergic symptoms.
  • Myth: This medicine causes immediate sedation.
    Fact: Bilastine is a non-sedating antihistamine, but some patients may experience mild drowsiness. Avoid driving until you know how it affects you.
  • Myth: You can stop this medicine as soon as symptoms improve.
    Fact: Do not stop this medicine without consulting your doctor. Stopping abruptly may cause symptoms to return.

🔄 Alternative Options

Generic Alternatives

  • Bilastine 20 mg + Montelukast 10 mg tablet (generic)

Brand Alternatives

  • Bilasure M 20mg/10mg Tablet

📊 Comparison with Similar Medicines

[{"medicine":"Bilastine + Montelukast","composition":"Bilastine 20 mg + Montelukast 10 mg","onset":"1 hour","sedation":"Low","frequency":"Once daily"},{"medicine":"Levocetirizine + Montelukast","composition":"Levocetirizine 5 mg + Montelukast 10 mg","onset":"1 hour","sedation":"Moderate","frequency":"Once daily"},{"medicine":"Fexofenadine + Montelukast","composition":"Fexofenadine 120 mg + Montelukast 10 mg","onset":"1 hour","sedation":"Low","frequency":"Once daily"}]

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