bifo cream

4.7 (14 reviews)

Bifonazole (1% w/w)

🏭 Adonis Laboratories Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Aug 22, 2026

📋 Prescription Required 💊 Generic Available

Medically Reviewed

SaathiMed Expert Panel | Aug 22, 2026

What is bifo cream used for?

Bifrazo Cream (Bifonazole) is used to treat DERMA. It contains Bifonazole (1% w/w), which Inhibits ergosterol synthesis by blocking 14α-demethylase, leading to accumulat. Always consult your doctor before use. Take as prescribed.

Generic Name: Bifonazole
Manufacturer: Adonis Laboratories Pvt Ltd
Form: Allopathy
Pregnancy Category: A
Prescription Required: Yes

💡 Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

💊 bifo cream Uses & Benefits

Topical treatment of dermatophyte infections (tinea pedis, tinea cruris, tinea corporis), pityriasis versicolor, and cutaneous candidiasis.

Off-label uses: Seborrheic dermatitis, onychomycosis (as adjunct).

📋 Drug Information

Generic Name(s)	Bifonazole
Brand Name	Bifrazo Cream
Manufacturer	Adonis Laboratories Pvt Ltd
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	DERMA
Action Class	Fungal ergosterol synthesis inhibitor
Route of Administration	Topical.
Storage	Store at room temperature (15-30°C); keep tightly closed.
Shelf Life	As per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionMinimal systemic absorption after topical application; approximately 2-4% absorbed through intact skin.

DistributionDistributes mainly in the stratum corneum and epidermis; systemic distribution is negligible.

Protein BindingNot applicable due to minimal systemic absorption.

MetabolismHepatic via CYP450 enzymes, primarily CYP3A4, but metabolism is minimal due to low systemic absorption.

Half-LifeNot applicable for topical use; systemic half-life is not clinically relevant.

ExcretionPrimarily excreted in feces (biliary) and urine as metabolites; negligible systemic excretion.

BioavailabilityNot applicable for topical formulation.

Onset of ActionWithin 24-48 hours of application.

Peak Plasma TimeNot applicable; minimal systemic absorption.

Duration of ActionUp to 72 hours after single application due to prolonged skin retention.

How It Works

Inhibits ergosterol synthesis by blocking 14α-demethylase, leading to accumulation of toxic sterols and fungal cell death.

Mechanism Steps

1Bifonazole binds to the heme iron of fungal CYP51 (14α-demethylase).

2Inhibits the conversion of lanosterol to ergosterol.

3Depletes ergosterol in fungal cell membrane.

💡 How to Take bifo cream

Follow your doctor's prescription exactly.

⚠️ Side Effects of bifo cream

✅ Common Side Effects

Local irritation
burning
stinging
erythema
pruritus

🚨 Serious Side Effects

Allergic contact dermatitis
angioedema (rare)

⚠️ Rare Side Effects

Bullous dermatitis
urticaria

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

🍽️ Food Interactions

None known.

🍷 Alcohol Interaction

No known interaction.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to bifonazole or any component of the cream.

📊 Monitoring Parameters

Clinical improvement; skin irritation; liver function tests if prolonged use.

🤱 Lactation Safety

Safe; minimal systemic absorption, unlikely to be excreted in breast milk.

💊 Overdose Management

Overdose unlikely; if ingested, symptomatic treatment.

⏰ Missed Dose

Apply as soon as remembered; if near next dose, skip missed dose.

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 22, 2026

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🔄 Substitutes for bifo cream

View All

Alternative brands with exact same active ingredient (Bifonazole (1% w/w)):

Medical Note: Always consult your doctor before switching medications.

⭐ User Reviews

Regular Customer Jul 10, 2026

Effective and reliable. Worked as expected.

Verified User Jul 10, 2026