adnurve sr tablet
What is adnurve sr tablet used for?
This medicine contains Pregabalin (75mg) + Nortriptyline (10mg) and is used to treat NEURO CNS. Pregabalin binds to alpha-2-delta subunit of voltage-gated calcium channels, reducing calcium influx. Always consult your doctor before use.
- Generic Name: Pregabalin + Nortriptyline
- Manufacturer: Adonis Laboratories Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Category A
- Prescription Required: Yes
💊 adnurve sr tablet Uses & Benefits
Neuropathic pain, fibromyalgia, generalized anxiety disorder, depression.
Off-label uses: Chronic pain, migraine prophylaxis, social anxiety disorder.
📋 Drug Information
| Generic Name(s) | Pregabalin + Nortriptyline |
| Brand Name | Axogurd NT Tablet SR |
| Manufacturer | Adonis Laboratories Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | Gabapentinoid + Tricyclic Antidepressant |
| Route of Administration | Oral |
| Storage | Store at 20-25°C, protect from light and moisture. |
| Shelf Life | As per manufacturer |
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Pregabalin binds to alpha-2-delta subunit of voltage-gated calcium channels, reducing calcium influx and neurotransmitter release. Nortriptyline inhibits reuptake of norepinephrine and serotonin, increasing their synaptic concentrations.
Mechanism Steps
💡 How to Take adnurve sr tablet
Follow your doctor's prescription exactly.
⚠️ Side Effects of adnurve sr tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| MAOIs | Major | Hypertensive crisis, serotonin syndrome |
| CYP2D6 inhibitors | Major | Increased nortriptyline levels, toxicity |
| CNS depressants | Major | Additive sedation, respiratory depression |
| Anticholinergics | Moderate | Increased anticholinergic side effects |
| Antihypertensives | Moderate | Enhanced hypotensive effect |
| Grapefruit juice | Moderate | Increased nortriptyline levels |
🚨 Major Interactions
- MAOIs
- CYP2D6 inhibitors (e.g., paroxetine, fluoxetine)
- CYP3A4 inhibitors (e.g., ketoconazole)
- Other CNS depressants (e.g., benzodiazepines, opioids)
⚡ Moderate Interactions
- Anticholinergics
- Antihypertensives
- Sympathomimetics
- Cimetidine
- Quinidine
🍷 Alcohol Interaction
Avoid alcohol; increased CNS depression and risk of seizures.
🛡️ Safety & Warnings
🚫 Contraindications
Hypersensitivity, recent MI, concurrent MAOI use, severe hepatic impairment, narrow-angle glaucoma, urinary retention.
🤱 Lactation Safety
Not recommended; both drugs excreted in breast milk.
💊 Overdose Management
Supportive care, activated charcoal, ECG monitoring, benzodiazepines for seizures, sodium bicarbonate for cardiac toxicity.
⏰ Missed Dose
Take as soon as remembered unless near next dose; skip if close to next dose.
🔄 Substitutes for adnurve sr tablet
View AllAlternative brands with exact same active ingredient:
-
megaseep nt 75mg/10mg tabletSeepi Pharma Pvt Ltd ₹18.00 92.5% CHEAPER
-
nervzone np tabletZeelab Pharmacy Pvt Ltd ₹30.00 87.5% CHEAPER
-
davaindia pregabalin+nortriptyline 75mg/10mg tabletDavaindia Generic Pharmacy ₹35.00 85.4% CHEAPER
-
stayhappi pregabalin+nortriptyline 75mg/10mg tabletSarvagunaushdhi Pvt Ltd ₹56.25 76.6% CHEAPER
-
ezinuro nt 75mg/10mg tabletDR Best pharmaceuticals Pvt Ltd ₹60.94 74.6% CHEAPER
Medical Note: Always consult your doctor before switching medications.