Gardenal 60 Tablet (Phenobarbitone 60mg): Complete Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Seizures that do not stop or occur in clusters
- Difficulty breathing or slow, shallow breathing
- Severe drowsiness or confusion
- Skin rash, blistering, or peeling
- Unusual bleeding or bruising
- Yellowing of the skin or eyes
- Severe abdominal pain or vomiting
- Irregular heartbeat or chest pain
If experiencing severe symptoms, call emergency services immediately.
What is barbinal 60mg tablet used for?
This medicine contains phenobarbitone 60 mg, a barbiturate anticonvulsant used to treat epilepsy and certain types of seizures. It works by calming abnormal brain activity. It is a prescription medicine and should never be stopped suddenly.
- Generic Name: Phenobarbitone (60mg)
- Manufacturer: Biochem Pharmaceutical Industries
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 barbinal 60mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा फेनोबार्बिटोन 60 मिलीग्राम युक्त एक प्रिस्क्रिप्शन दवा है, जिसका उपयोग मुख्य रूप से मिर्गी और कुछ प्रकार के दौरे (जैसे जनरलाइज्ड टॉनिक-क्लोनिक दौरे और पार्शियल दौरे) के इलाज के लिए किया जाता है। यह मस्तिष्क में असामान्य विद्युत गतिविधि को धीमा करके दौरे को रोकने में मदद करती है। कभी-कभी गंभीर अनिद्रा या शराब छुड़ाने के दौरान होने वाले दौरों को रोकने के लिए भी इसका उपयोग किया जाता है, लेकिन केवल डॉक्टर की सख्त निगरानी में। इस दवा को कभी भी अचानक बंद नहीं करना चाहिए, क्योंकि इससे गंभीर दौरे पड़ सकते हैं।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में नींद आना, चक्कर आना, थकान, अस्थिरता और ध्यान केंद्रित करने में कठिनाई शामिल हैं। ये प्रभाव आमतौर पर शुरुआत में या खुराक बढ़ाने पर अधिक महसूस होते हैं और समय के साथ कम हो जाते हैं। कुछ लोगों को मतली, उल्टी या कब्ज हो सकती है। दुर्लभ लेकिन गंभीर दुष्प्रभावों में त्वचा पर गंभीर प्रतिक्रियाएं, रक्त विकार और लीवर की क्षति शामिल हैं। लंबे समय तक उपयोग से निर्भरता और सहनशीलता विकसित हो सकती है। यदि आपको कोई असामान्य लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को कभी भी अचानक बंद न करें, क्योंकि इससे गंभीर दौरे पड़ सकते हैं। हमेशा डॉक्टर के निर्देशानुसार खुराक कम करें। जब तक आपको पता न चले कि यह दवा आप पर कैसा असर करती है, तब तक वाहन चलाने या भारी मशीनरी चलाने से बचें, क्योंकि इससे नींद और सुस्ती आ सकती है। इस दवा के साथ शराब न पिएं, क्योंकि इससे गंभीर दुष्प्रभाव हो सकते हैं। अपने डॉक्टर को अपनी सभी दवाओं के बारे में बताएं। यदि आप गर्भवती हैं, गर्भधारण की योजना बना रही हैं या स्तनपान करा रही हैं, तो अपने डॉक्टर से सलाह लें। नियमित रक्त परीक्षण कराते रहें। इस दवा को बच्चों की पहुंच से दूर सुरक्षित स्थान पर रखें।
💊 barbinal 60mg tablet Uses & Benefits
[{"condition":"Generalized tonic-clonic seizures","description":"Used to prevent and control generalized tonic-clonic seizures in adults and children.","evidence":"Well-established"},{"condition":"Partial (focal) seizures","description":"Effective for simple and complex partial seizures, with or without secondary generalization.","evidence":"Well-established"},{"condition":"Status epilepticus","description":"Used as a second-line treatment for status epilepticus after benzodiazepines, often given intravenously in hospital settings.","evidence":"Established"},{"condition":"Sedation for severe insomnia","description":"Occasionally prescribed for short-term management of severe insomnia, but not recommended due to high risk of dependence.","evidence":"Limited"},{"condition":"Prevention of withdrawal seizures","description":"May be used in the management of alcohol or sedative withdrawal to prevent seizures, under close supervision.","evidence":"Limited"}]
Off-label uses: [{"condition":"Essential tremor","description":"Sometimes prescribed off-label to reduce tremor, but not first-line.","evidence":"Limited"},{"condition":"Migraine prophylaxis","description":"Rarely used off-label for preventing migraines, but evidence is weak.","evidence":"Limited"}]
Primary treatment for: Epilepsy
Also treats: Generalized tonic-clonic seizures, Partial seizures, Status epilepticus, Severe insomnia, Alcohol withdrawal seizures
📋 Drug Information
| Generic Name(s) | Phenobarbitone (60mg) |
| Brand Name | barbinal 60mg tablet |
| Manufacturer | Biochem Pharmaceutical Industries |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | Barbiturate |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Keep away from direct sunlight and moisture. Store in the original container, tightly closed. Keep out of reach of children and pets. |
| Shelf Life | The shelf life of this medicine is typically 24 months from the date of manufacture. Check the expiry date on the packaging before use. |
| WHO Guideline | The World Health Organization (WHO) includes phenobarbitone in its Model List of Essential Medicines for the treatment of epilepsy. WHO recommends it as an option for partial and generalized tonic-clonic seizures, especially in resource-limited settings, but notes the need for monitoring and caution due to its side effect profile. |
| ICMR Guideline | The Indian Council of Medical Research (ICMR) recognizes phenobarbitone as an effective anticonvulsant for certain seizure types. It is included in standard treatment guidelines for epilepsy, but its use is limited by its sedative effects and potential for dependence. Regular monitoring is advised. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by enhancing the inhibitory effects of gamma-aminobutyric acid (GABA) in the brain. It binds to a specific site on the GABA-A receptor, which increases the duration of chloride channel opening. This leads to hyperpolarization of neurons and raises the seizure threshold, making it harder for abnormal electrical activity to spread. At higher concentrations, it also reduces the effects of excitatory neurotransmitters like glutamate. The overall result is a calming effect on the central nervous system, which helps prevent seizures and induces sedation.
Mechanism Steps
💡 How to Take barbinal 60mg tablet
Strength: This medicine is available as a 60 mg immediate-release tablet for oral administration.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine for epilepsy is 60 to 180 mg once daily at bedtime, or in divided doses. For status epilepticus, an initial intravenous dose of 10 to 20 mg/kg may be given, followed by maintenance doses. For sedation, a lower dose of 30 to 60 mg may be used. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and response to treatment. Regular monitoring of serum levels is recommended to ensure therapeutic levels and avoid toxicity. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician for appropriate dosing in children. |
| Elderly Dosage | Elderly patients are more sensitive to the effects of this medicine, especially sedation, confusion, and unsteadiness. Lower initial doses are recommended, and dose increases should be made slowly. Regular monitoring for side effects and drug interactions is essential. |
| Renal Impairment | In patients with renal impairment, the dose of this medicine may need to be reduced because it is excreted by the kidneys. Monitor renal function and adjust dose accordingly. Consult a doctor for specific dosing recommendations. |
| Hepatic Impairment | In patients with hepatic impairment, the metabolism of this medicine may be reduced, leading to increased blood levels and risk of toxicity. Dose reduction and close monitoring are advised. Use with caution in severe liver disease. |
| Maximum Daily Dose | The maximum daily dose of this medicine for epilepsy is generally 300 mg, but this may vary based on individual patient factors. Doses above 300 mg per day are rarely used and require close monitoring. Always follow your doctor's prescription. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of barbinal 60mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Oral contraceptives | Major | |
| Valproic acid | Major | |
| Benzodiazepines | Major | |
| Opioids | Major | |
| Carbamazepine | Moderate | |
| Phenytoin | Moderate | |
| Corticosteroids | Moderate | |
| Doxycycline | Moderate | |
| Tricyclic antidepressants | Moderate |
🚨 Major Interactions
- Warfarin
- Oral contraceptives
- Valproic acid
- Benzodiazepines
- Opioids
⚡ Moderate Interactions
- Carbamazepine
- Phenytoin
- Corticosteroids
- Doxycycline
- Tricyclic antidepressants
🍷 Alcohol Interaction
Alcohol should be completely avoided while taking this medicine. Both alcohol and phenobarbitone depress the central nervous system, and their combined use can lead to severe sedation, respiratory depression, coma, and even death. Alcohol can also increase the risk of seizures if you stop drinking suddenly. If you have a history of alcohol use, discuss it with your doctor before starting this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to phenobarbitone or other barbiturates","Severe respiratory depression or airway obstruction","Acute intermittent porphyria","Severe hepatic impairment","Severe renal impairment","History of drug dependence or abuse","Pregnancy (relative contraindication; use only if clearly needed)"]
⚠️ Warnings & Precautions
["May cause severe skin reactions; discontinue at first sign of rash.","Can cause dependence and withdrawal seizures; do not stop abruptly.","May impair mental and physical abilities; avoid driving or operating machinery.","Can cause respiratory depression; use with caution in patients with respiratory disease.","May interact with many drugs; review all medications with your doctor.","Long-term use may lead to folate and vitamin D deficiency; monitor and supplement as needed.","Use with caution in elderly patients due to increased sensitivity to side effects.","May worsen porphyria; avoid in patients with this condition."]
🤱 Lactation Safety
Phenobarbitone is excreted in breast milk and can cause sedation and feeding difficulties in breastfed infants. Breastfeeding while taking this medicine is not recommended, especially with high doses. Consult your doctor to weigh the benefits and risks.
💊 Overdose Management
Overdose of this medicine can be life-threatening and requires immediate medical attention. Symptoms include severe drowsiness, confusion, slurred speech, slow breathing, weak pulse, and loss of consciousness. If you suspect an overdose, call emergency services immediately. Treatment in a hospital may include activated charcoal, gastric lavage, intravenous fluids, and supportive care. There is no specific antidote, but urinary alkalinization may enhance elimination. Hemodialysis may be considered in severe cases.
⏰ Missed Dose
If you miss a dose of this medicine, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one. If you miss multiple doses, contact your doctor for advice. Never stop taking this medicine suddenly without medical supervision.
Additional Safety Advice
Never stop taking this medicine suddenly, as this can trigger severe withdrawal seizures. Always follow your doctor's instructions for tapering the dose. Avoid driving or operating heavy machinery until you know how this medicine affects you, because it can cause drowsiness and slow your reactions. Do not drink alcohol while taking this medicine, as it can increase sedation and the risk of serious side effects. Tell your doctor about all other medicines you are taking, including over-the-counter products and herbal supplements, because this medicine can interact with many drugs. If you are pregnant, planning to become pregnant, or breastfeeding, talk to your doctor about the risks and benefits. Keep all appointments for blood tests and check-ups, as this medicine can affect your liver, blood cells, and vitamin D levels. Store this medicine securely out of reach of children, as accidental overdose can be life-threatening.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to the sedative and cognitive effects of this medicine. Lower doses are recommended, and regular monitoring for falls, confusion, and drug interactions is essential. Dose adjustments may be needed based on kidney and liver function.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before conception. This medicine may increase the risk of birth defects. Your doctor may adjust your treatment or switch to a safer alternative. Use effective contraception while taking this medicine unless you are planning a pregnancy under medical guidance.
🏥 Post-Surgery Considerations
After surgery, inform your surgeon and anesthesiologist that you are taking this medicine. It can interact with anesthetic agents and increase the risk of respiratory depression. Your dose may need to be adjusted during the perioperative period.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. It can interact with sedatives and anesthetics used in dentistry. Your dentist may need to adjust medications or take extra precautions.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine can cause drowsiness and unsteadiness, especially when starting treatment or after a dose increase. Avoid activities that require alertness, such as swimming or cycling, until you know how the medicine affects you. Consult your doctor before starting any new exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause drowsiness, dizziness, and difficulty concentrating, which may affect your ability to work or perform daily tasks. Avoid driving or operating heavy machinery until you know how it affects you. Inform your employer if your job involves safety-sensitive tasks. With proper dose adjustment, many people can continue their normal activities.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. If you experience severe side effects such as a skin rash, difficulty breathing, or unusual bleeding, seek immediate medical attention. Your doctor may decide to stop the medicine gradually if it is no longer needed or if a different treatment is more appropriate.
📅 Long-Term Use Effects
Long-term use of this medicine can lead to physical dependence, tolerance, and withdrawal symptoms if stopped abruptly. It may cause cognitive impairment, memory problems, and decreased bone density (osteomalacia). Regular monitoring of liver function, blood counts, and vitamin D levels is recommended. Dose adjustments may be needed over time. Do not stop the medicine without medical supervision.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Medicines like levetiracetam, lamotrigine, or valproic acid may be used as alternatives.
Evidence: Well-establishedA high-fat, low-carbohydrate diet may help control seizures in some patients, especially children.
Evidence: Established for certain types of epilepsyFor drug-resistant epilepsy, surgery may be an option to remove the seizure focus.
Evidence: Established for selected patientsA device implanted under the skin stimulates the vagus nerve to reduce seizures.
Evidence: Established for refractory epilepsy💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine may interact with certain vaccines, but generally, vaccinations are not contraindicated. However, live vaccines should be avoided if you have a weakened immune system. Consult your doctor before receiving any vaccine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your hand luggage to avoid loss or temperature extremes. If crossing time zones, consult your doctor about adjusting the dosing schedule. Store it at room temperature and away from direct sunlight. Check the laws of your destination country regarding controlled substances, as phenobarbitone may be regulated. Always carry enough supply for your entire trip.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working within 30-60 minutes after oral intake, but full seizure control may take several weeks as the dose is adjusted and steady blood levels are achieved.
A: No, you should never stop this medicine suddenly. Doing so can cause severe withdrawal seizures. Always consult your doctor before making any changes.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: This medicine may harm the unborn baby. Use during pregnancy only if clearly needed and under your doctor's supervision. Discuss pregnancy plans with your doctor.
A: No, alcohol should be completely avoided as it can increase sedation, respiratory depression, and the risk of serious side effects.
🤔 Common Patient Concerns
🔄 Substitutes for barbinal 60mg tablet
View AllAlternative brands with exact same active ingredient:
-
phenotone 60mg tabletCipla Ltd ₹5.50 67.4% CHEAPER
-
phenobarb 60mg tabletIntas Pharmaceuticals Ltd ₹11.32 32.9% CHEAPER
-
epikon 60mg tabletKonark Biochem ₹13.13 22.2% CHEAPER
-
epitan 60mg tabletReliance Formulation Pvt Ltd ₹15.00 11.1% CHEAPER
-
borphen 60mg tabletRyon Pharma ₹16.50 2.3% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is a sleeping pill and can be taken for any sleep problem.
Fact: This medicine is a potent anticonvulsant with a high risk of dependence. It is not recommended for routine sleep problems and should only be used for severe insomnia under strict medical supervision. - Myth: You can stop taking this medicine once your seizures are controlled.
Fact: Stopping this medicine suddenly can cause severe withdrawal seizures. It must be tapered gradually under a doctor's supervision. - Myth: This medicine is safe to take with alcohol.
Fact: Alcohol greatly increases the sedative and respiratory depressant effects of this medicine, which can be life-threatening. - Myth: This medicine is not addictive.
Fact: This medicine has a high potential for physical and psychological dependence. It should be used only as prescribed.
🔄 Alternative Options
Generic Alternatives
- Phenobarbitone 60 mg tablet (various manufacturers)
Brand Alternatives
- Gardenal 60 tablet