aztatin 20mg tablet - Lovastatin (20mg) medicine

Aztatin 20mg Tablet

No reviews yet
Lovastatin (20mg)
🏭 Sun Pharmaceutical Industries Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 27, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Reviewed by
SaathiMed Expert Panel | Oct 27, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
Related Clinical Tools & Lab Test Analyzers
View All 26 Tools →

What is aztatin 20mg tablet used for?

This medicine contains Lovastatin (20mg) and is used to treat CARDIAC. Competitive inhibitor of HMG-CoA reductase, the rate-limiting enzyme in cholesterol biosynthesis.. Always consult your doctor before use.

  • Generic Name: Lovastatin
  • Manufacturer: Sun Pharmaceutical Industries Ltd
  • Form: Allopathy
  • Pregnancy Category: Category X
  • Prescription Required: Yes
💡 Did You Know? Over 80% of the antiretroviral drugs used globally to combat AIDS are supplied by Indian pharmaceutical companies.

💊 aztatin 20mg tablet Uses & Benefits

Primary hypercholesterolemia, mixed dyslipidemia, prevention of cardiovascular events in patients with multiple risk factors.

Off-label uses: Familial hypercholesterolemia, nephrotic syndrome, post-transplant hyperlipidemia.

📋 Drug Information

Generic Name(s)Lovastatin
Brand NameAztatin 10mg Tablet
ManufacturerSun Pharmaceutical Industries Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassCARDIAC
Action ClassHMG CoA inhibitors (statins)
Route of AdministrationOral
StorageStore at 20-25°C (68-77°F) in a tight container, protected from light and moisture.
Shelf LifeAs per manufacturer

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionRapidly absorbed from the gastrointestinal tract; peak plasma concentrations occur within 2-4 hours. Food increases absorption.
DistributionExtensively distributed to tissues; crosses the blood-brain barrier minimally. Highly bound to plasma proteins.
Protein Binding>95%
MetabolismExtensively metabolized in the liver via CYP3A4 to active and inactive metabolites.
Half-Life1-2 hours (parent drug); active metabolites have longer half-life.
ExcretionPrimarily excreted in feces (83%) and urine (10%) as metabolites.
Bioavailability<5% due to extensive first-pass metabolism.
Onset of ActionWithin 2 weeks of therapy initiation.
Peak Plasma Time2-4 hours
Duration of ActionUp to 24 hours (once-daily dosing).

How It Works

Competitive inhibitor of HMG-CoA reductase, the rate-limiting enzyme in cholesterol biosynthesis.

Mechanism Steps

1Lovastatin is a prodrug that is hydrolyzed to the active β-hydroxy acid form.
2Competitively inhibits HMG-CoA reductase, the enzyme that converts HMG-CoA to mevalonate.
3Reduces intracellular cholesterol synthesis in the liver.
4Leads to upregulation of LDL receptors on hepatocytes.
5Increases clearance of LDL from the bloodstream.
6Reduces VLDL synthesis and secretion.
7Results in decreased total cholesterol, LDL-C, and triglycerides, with a modest increase in HDL-C.

💡 How to Take aztatin 20mg tablet

Follow your doctor's prescription exactly.

⚠️ Side Effects of aztatin 20mg tablet

✅ Common Side Effects

Headache
Dizziness
Nausea
Abdominal pain
Diarrhea
Constipation
Flatulence
Myalgia
Asthenia

🚨 Serious Side Effects

Rhabdomyolysis
Myopathy
Hepatotoxicity (elevated transaminases)
Acute renal failure secondary to rhabdomyolysis

⚠️ Rare Side Effects

Peripheral neuropathy
Hypersensitivity reactions (angioedema, urticaria)
Lupus-like syndrome
Gynecomastia
Alopecia

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
CYP3A4 inhibitors Major Increased risk of myopathy/rhabdomyolysis
Grapefruit juice Major Increased lovastatin plasma concentration
Gemfibrozil Major Increased risk of myopathy/rhabdomyolysis
Cyclosporine Major Increased risk of myopathy/rhabdomyolysis
Danazol Major Increased risk of myopathy/rhabdomyolysis
Amiodarone Major Increased risk of myopathy/rhabdomyolysis
Verapamil Major Increased risk of myopathy/rhabdomyolysis
Diltiazem Major Increased risk of myopathy/rhabdomyolysis
Warfarin Moderate Increased INR and bleeding risk
Digoxin Moderate Increased digoxin levels
Oral contraceptives Moderate Increased contraceptive levels
Fibrates Moderate Increased risk of myopathy
Niacin Moderate Increased risk of myopathy
Colchicine Moderate Increased risk of myopathy
Antacids Minor Decreased absorption (separate by 2 hours)
Cholestyramine Minor Decreased absorption (separate by 4 hours)
Colestipol Minor Decreased absorption (separate by 4 hours)

🚨 Major Interactions

  • CYP3A4 inhibitors (e.g., itraconazole, ketoconazole, erythromycin, clarithromycin, telithromycin, HIV protease inhibitors, nefazodone)
  • Grapefruit juice
  • Gemfibrozil
  • Cyclosporine
  • Danazol
  • Amiodarone
  • Verapamil
  • Diltiazem

⚡ Moderate Interactions

  • Warfarin
  • Digoxin
  • Oral contraceptives
  • Fibrates (other than gemfibrozil)
  • Niacin (≥1 g/day)
  • Colchicine

🍷 Alcohol Interaction

Excessive alcohol consumption may increase risk of hepatotoxicity.

🛡️ Safety & Warnings

🚫 Contraindications

Active liver disease, unexplained persistent elevations of serum transaminases, pregnancy, lactation, hypersensitivity to lovastatin.

🤱 Lactation Safety

Contraindicated; excreted in breast milk.

💊 Overdose Management

Symptomatic and supportive; monitor liver function and CK levels; consider gastric lavage if recent ingestion.

⏰ Missed Dose

Take as soon as remembered unless almost time for next dose; do not double dose.

🔄 Substitutes for aztatin 20mg tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

😊 Was this information helpful?

Browse Medicines A-Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Back to Medicines Directory