Azenam 250mg Injection - Uses, Price, Side Effects
What is azenam 250mg injection used for?
Azenam 250mg Injection contains Aztreonam, a monobactam antibiotic used to treat moderate to severe bacterial infections caused by susceptible Gram-negative bacteria, including urinary tract, respiratory, intra-abdominal, and gynecological infections. It works by inhibiting bacterial cell wall synthesis, leading to bacterial death. It is administered intramuscularly or intravenously under medical supervision.
- Generic Name: Aztreonam
- Manufacturer: Aristo Pharmaceuticals Pvt Ltd
- Form: Allopathy
- Pregnancy Category: B
- Prescription Required: Yes
๐ azenam 250mg injection Uses & Benefits
Treatment of infections caused by susceptible Gram-negative bacteria including urinary tract infections, lower respiratory tract infections, septicemia, skin and skin structure infections, intra-abdominal infections, and gynecologic infections.
Off-label uses: Febrile neutropenia (in combination), Meningitis (with inflamed meninges)
๐ Drug Information
| Generic Name(s) | Aztreonam |
| Brand Name | Azenam 1gm Injection |
| Manufacturer | Aristo Pharmaceuticals Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Monobactams |
| Route of Administration | Intravenous (IV) or intramuscular (IM) injection. |
| Storage | Store at 20-25ยฐC (68-77ยฐF); protect from light; reconstituted solutions stable for 48 hours at room temperature or 7 days under refrigeration. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Inhibits bacterial cell wall synthesis by binding to penicillin-binding protein 3 (PBP3), leading to cell lysis and death.
Mechanism Steps
๐ก How to Take azenam 250mg injection
Follow your doctor's prescription exactly.
Dosage Timeline
โ ๏ธ Side Effects of azenam 250mg injection
โ Common Side Effects
- Injection site reactions (pain, phlebitis)
- Diarrhea
- Nausea
- Vomiting
- Rash
๐จ Serious Side Effects
- Severe hypersensitivity reactions (anaphylaxis)
- Clostridioides difficile-associated diarrhea
- Seizures
- Hepatotoxicity
โ ๏ธ Rare Side Effects
- Pseudomembranous colitis
- Blood dyscrasias (neutropenia, thrombocytopenia)
- Interstitial nephritis
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Moderate | Increased INR and bleeding risk |
| Probenecid | Moderate | Decreased renal excretion of aztreonam |
| Chloramphenicol | Moderate | Antagonistic antibacterial effect |
๐จ Major Interactions
- Warfarin
- Live Typhoid Vaccine
- BCG Vaccine
โก Moderate Interactions
- Probenecid
- Aminoglycosides
- Furosemide
โน๏ธ Minor Interactions
- Chloramphenicol
- Tetracyclines
๐ฝ๏ธ Food Interactions
No significant food interactions; injection only.
๐ท Alcohol Interaction
No known interaction.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to aztreonam or any component of the formulation.
๐ Monitoring Parameters
Renal function (especially in elderly or with concurrent nephrotoxic drugs), liver function tests, signs of hypersensitivity, and superinfection.
๐คฑ Lactation Safety
Excreted in breast milk in low concentrations; generally considered compatible with breastfeeding.
๐ Overdose Management
Supportive care; hemodialysis may enhance elimination.
โฐ Missed Dose
Administer as soon as possible; if near next dose, skip missed dose and resume regular schedule.
๐จโโ๏ธ Reviewed by Expert
๐ Substitutes for azenam 250mg injection
View AllAlternative brands with exact same active ingredient (Aztreonam (250mg)):
-
Trezam 250mg InjectionGlenmark Pharmaceuticals Ltd โน162.77 28.7% CHEAPER
-
azvin 250mg injectionArvincare Pharma โน230.00 0.8% COSTLIER
-
deonam 250mg injectionDr. Edwin Lab โน250.00 9.6% COSTLIER
-
azinox 250mg injectionKritikos Care โน270.00 18.3% COSTLIER
Medical Note: Always consult your doctor before switching medications.