azedra plus tablet - Citicoline (500mg) + Piracetam (800mg) medicine

Ceham-P Tablet: Comprehensive Guide to Uses, Side Effects, and Safety

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🏭 AAR ESS Remedies Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 23, 2026
⚠️ Nephrotoxicity Risk 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Limited to moderate, depending on the indication.
Reviewed by
SaathiMed Expert Panel | Sep 23, 2026

When to Call Your Doctor IMMEDIATELY

  • Sudden swelling of face, lips, or throat
  • Difficulty breathing or swallowing
  • Severe dizziness or fainting
  • Unusual bleeding or bruising
  • Chest pain or irregular heartbeat
  • Severe headache with visual changes
  • Confusion or hallucinations

If experiencing severe symptoms, call emergency services immediately.

What is azedra plus tablet used for?

This medicine is a combination of Citicoline and Piracetam used to improve cognitive function after stroke or brain injury. It works by protecting brain cells and enhancing blood flow. It is available by prescription only.

  • Generic Name: Citicoline + Piracetam
  • Manufacturer: AAR ESS Remedies Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 azedra plus tablet के बारे में (Hindi Summary)

उपयोग: यह दवा सिटिकोलिन और पिरासिटाम का संयोजन है, जिसका उपयोग मस्तिष्क की कार्यक्षमता में सुधार के लिए किया जाता है। यह स्ट्रोक, मस्तिष्क की चोट, और उम्र से संबंधित याददाश्त की कमी में मदद कर सकती है। यह दवा मस्तिष्क की कोशिकाओं की रक्षा करती है और रक्त प्रवाह को बढ़ाती है।

साइड इफेक्ट्स: आम दुष्प्रभावों में सिरदर्द, चक्कर आना, मतली, और पेट की गड़बड़ी शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन एलर्जी, सांस लेने में कठिनाई, या गंभीर चक्कर आ सकते हैं। किसी भी गंभीर लक्षण पर तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। खुराक न बढ़ाएं। इसे पानी के साथ निगलें, भोजन के साथ या बिना। जब तक आपको इसका असर पता न चले, वाहन न चलाएं। गर्भावस्था या स्तनपान के दौरान डॉक्टर से सलाह लें।

💡 Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

💊 azedra plus tablet Uses & Benefits

[{"condition":"Stroke recovery","description":"This medicine is used to support cognitive and neurological recovery after an ischemic stroke.","evidence":"Moderate"},{"condition":"Traumatic brain injury","description":"It may help improve cognitive function and reduce recovery time in patients with mild to moderate head injury.","evidence":"Limited"},{"condition":"Age-related cognitive decline","description":"This medicine is sometimes prescribed to improve memory and attention in older adults with mild cognitive impairment.","evidence":"Limited"},{"condition":"Vascular dementia","description":"It may be used as an adjunct to improve cognitive symptoms in vascular dementia.","evidence":"Limited"}]

Off-label uses: [{"condition":"Attention deficit hyperactivity disorder (ADHD)","description":"Occasionally used off-label to improve attention and impulse control, but evidence is insufficient.","evidence":"Insufficient"},{"condition":"Vertigo","description":"Sometimes prescribed off-label for vertigo, though its efficacy is not well established.","evidence":"Limited"}]

Primary treatment for: Cognitive impairment associated with stroke, traumatic brain injury, or age-related decline

Also treats: Vascular dementia, Mild cognitive impairment

📋 Drug Information

Generic Name(s)Citicoline + Piracetam
Brand NameAzedra Plus Tablet
ManufacturerAAR ESS Remedies Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassNEURO CNS
Action ClassNootropic
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a dry place, away from direct sunlight. Keep in the original container.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine at the same time each day to maintain consistent levels.
2
Do not stop taking this medicine abruptly without consulting your doctor.
3
Inform your doctor if you experience any unusual bleeding or bruising.
4
Avoid alcohol while taking this medicine as it may increase dizziness.
5
Stay well hydrated throughout the day to support kidney function.
6
Report any persistent headache or dizziness to your doctor.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

Memory loss
This medicine is commonly prescribed for cognitive impairment.
Likely Use
Fever
This medicine is not a fever reducer.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionCiticoline is rapidly absorbed after oral administration and undergoes first-pass metabolism. Piracetam is also well absorbed from the gastrointestinal tract. However, specific bioavailability data for this combination is not established from the available information.
DistributionBoth components are distributed widely throughout the body, with citicoline crossing the blood-brain barrier. Piracetam also reaches the brain. Protein binding information is not established from the available information.
Protein BindingNot established from the available information.
MetabolismCiticoline is metabolized in the liver and intestines to cytidine and choline. Piracetam is not significantly metabolized and is excreted largely unchanged in urine.
Half-LifeThe elimination half-life of citicoline is approximately 3-4 hours. Piracetam has a half-life of about 4-5 hours in healthy adults, but this may be prolonged in renal impairment.
ExcretionCiticoline metabolites are excreted in urine and feces. Piracetam is excreted primarily unchanged in urine.
BioavailabilityNot established from the available information.
Onset of ActionThe onset of action for cognitive effects may take several days to weeks of regular use.
Peak Plasma TimeNot established from the available information.
Duration of ActionNot established from the available information.

How It Works

This medicine combines two nootropic agents. Citicoline is a precursor to phosphatidylcholine, which is essential for neuronal membrane integrity and repair. It also increases the levels of acetylcholine, dopamine, and noradrenaline in the brain. Piracetam modulates neurotransmission and improves cerebral microcirculation by enhancing red blood cell deformability and reducing platelet aggregation. Together, they enhance cognitive function and neuroprotection.

Mechanism Steps

1
Citicoline conversion: Citicoline is hydrolyzed to cytidine and choline, which cross the blood-brain barrier and are used to synthesize phosphatidylcholine and acetylcholine.
2
Membrane stabilization: Phosphatidylcholine integrates into neuronal membranes, enhancing their fluidity and repair.
3
Neurotransmitter enhancement: Increased acetylcholine and dopamine levels improve synaptic transmission and cognitive processing.
4
Piracetam modulation: Piracetam enhances neuronal plasticity and improves cerebral blood flow by increasing red blood cell deformability.

💡 How to Take azedra plus tablet

Strength: Citicoline 500 mg + Piracetam 800 mg immediate-release tablet

1Swallow the tablet whole with a glass of water.
2Take with or without food.
3Do not crush, chew, or break the tablet.
4Take at the same time each day to maintain consistent levels.
5If you miss a dose, follow the missed dose instructions.

Dosage Information

Adult DosageThe usual adult dose of this medicine is one tablet taken orally once or twice daily, or as directed by your physician. The exact dose and duration depend on the condition being treated, your age, kidney function, and other medications you are taking. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may require dose adjustment based on renal function. Consult your doctor.
Renal ImpairmentDose adjustment is required in patients with renal impairment. Consult your doctor for specific recommendations.
Hepatic ImpairmentNo specific dose adjustment is established for hepatic impairment. Consult your doctor.
Maximum Daily DoseThe maximum recommended daily dose is not established from the available information. Do not exceed the dose prescribed by your doctor.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset.
Grapefruit
No known interaction
Not established.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of azedra plus tablet

✅ Common Side Effects

Headache (Common (5-10%))
Usually resolves on its own. Consult doctor if persistent.
Dizziness (Common (5-10%))
Avoid driving or operating machinery until you know how it affects you.
Nausea (Common (5-10%))
Take with food to reduce stomach upset.
Stomach upset (Common (5-10%))
Take with meals.
Restlessness (Uncommon (1-5%))
Consult doctor if it interferes with daily activities.

🚨 Serious Side Effects

Allergic reactions (rash, itching, swelling, difficulty breathing) (Rare (<0.1%))
Seek immediate medical attention.
Severe hypotension (Rare (<0.1%))
Seek immediate medical attention if you feel faint or have very low blood pressure.
Insomnia (Rare (<0.1%))
Consult doctor if it persists.

⚠️ Rare Side Effects

Increased libido
Consult doctor if concerned.
Hallucinations
Seek immediate medical attention.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major
Aspirin Major
Clopidogrel Major
Thyroid hormones Moderate
CNS stimulants Moderate
Alcohol Minor

🚨 Major Interactions

  • Anticoagulants (e.g., warfarin)
  • Antiplatelet agents (e.g., aspirin, clopidogrel)

⚡ Moderate Interactions

  • Thyroid hormones
  • CNS stimulants

🍷 Alcohol Interaction

Alcohol may increase the risk of dizziness, drowsiness, or other central nervous system effects. It is advisable to avoid alcohol while taking this medicine.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Hypersensitivity to citicoline or piracetam","Severe renal impairment (creatinine clearance < 20 mL/min)","Cerebral hemorrhage","Huntington's disease","Pregnancy and lactation (unless clearly needed)"]

⚠️ Warnings & Precautions

["Use with caution in patients with renal impairment.","May cause drowsiness; avoid driving or operating machinery until you know how it affects you.","Avoid abrupt discontinuation; consult your doctor before stopping.","Inform your doctor if you have a history of bleeding disorders.","Not recommended for children unless prescribed by a specialist."]

🤱 Lactation Safety

It is not known whether this medicine passes into breast milk. Consult your doctor before breastfeeding.

💊 Overdose Management

Overdose may cause severe nausea, dizziness, or hypotension. Seek immediate medical attention. Treatment is symptomatic and supportive.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose. Swallow the tablet whole with a glass of water, with or without food. Avoid driving or operating heavy machinery until you know how this medicine affects you. Inform your doctor if you have kidney or liver problems, or if you are pregnant or breastfeeding. Do not stop taking this medicine abruptly without consulting your doctor. Keep out of reach of children.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients may be more sensitive to side effects and may require dose adjustment based on renal function. Regular monitoring is advised.

🤰 Pregnancy Planning (TTC)

Consult your doctor if you are planning pregnancy. This medicine is not recommended during pregnancy unless clearly needed.

🏥 Post-Surgery Considerations

Inform your surgeon if you are taking this medicine, as it may affect bleeding risk. It may be stopped before surgery as advised.

🦷 Dental Procedures

Inform your dentist if you are taking this medicine, especially if you have a bleeding disorder or are on anticoagulants.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy diet rich in antioxidants.
🥗
Engage in regular mental exercises like puzzles.
😴
Stay physically active with low-impact exercises.
💧
Get adequate sleep to support brain health.
🧘
Avoid smoking and excessive alcohol.

🏋️ Exercise Considerations

Avoid strenuous exercise if you experience dizziness or fatigue. Consult your doctor before starting any new exercise regimen.

🥗 Diet Recommendations

Include omega-3 rich foods like fish.
Eat plenty of fruits and vegetables.
Stay well hydrated.
Limit processed foods and sugary drinks.

💼 Impact on Daily Work & Life

This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It may improve cognitive function, potentially enhancing work performance over time.

🛑 When to Stop This Medicine

Do not stop taking this medicine without consulting your doctor. If you experience severe side effects, seek medical advice immediately.

📅 Long-Term Use Effects

Long-term use of this medicine should be monitored by a doctor. Periodic assessment of cognitive function and renal function is recommended. Do not use for extended periods without medical supervision.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Cognitive rehabilitation therapy

Can complement medicine for cognitive recovery.

Evidence: Well-established
Physical therapy

Helps improve overall function after stroke.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

No specific interactions with vaccines are established. Consult your doctor for routine vaccinations.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from moisture. If traveling across time zones, adjust dosing times gradually under medical guidance. Check local customs regulations for prescription medicines.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 58-year-old man recovering from a mild stroke
He was prescribed this medicine as part of his rehabilitation. After 4 weeks, he noticed improvements in his memory and ability to concentrate. He took it regularly with breakfast and experienced only mild nausea initially, which subsided.
💡 Lesson: Consistent use and taking with food can improve tolerability and outcomes.
👤 A 72-year-old woman with age-related cognitive decline
She started this medicine after her doctor recommended it. Her family reported that she seemed more alert and engaged in conversations after 6 weeks. She did not experience any significant side effects.
💡 Lesson: This medicine may help improve cognitive function in older adults, but effects take time.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: It may take several weeks to notice improvements in cognitive function. Continue taking it as prescribed.

Q: Can I take it with other medicines?

A: Inform your doctor about all medicines you take, especially blood thinners, as interactions may occur.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for azedra plus tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can make you smarter instantly.
    Fact: It is not a smart drug; it supports cognitive recovery in specific medical conditions.
  • Myth: It is safe for everyone.
    Fact: It is contraindicated in certain conditions and requires a prescription.

🔄 Alternative Options

Generic Alternatives

  • Citicoline + Piracetam combination generics may be available.

Brand Alternatives

  • Ceham-P
  • Other brands containing Citicoline and Piracetam

📊 Comparison with Similar Medicines

[{"medicine":"Citicoline alone","difference":"Lacks Piracetam; may be less effective for certain cognitive symptoms."},{"medicine":"Piracetam alone","difference":"Lacks Citicoline; may not provide membrane stabilization benefits."}]

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