Axeclav 500mg/125mg Tablet - Uses, Price, Side Effects
What is axeclav 500mg/125mg tablet used for?
Axeclav 500mg/125mg tablet is a combination antibiotic containing Cefuroxime (500mg) and Clavulanic Acid (125mg). It is used to treat various bacterial infections such as respiratory tract infections, urinary tract infections, skin infections, and ear infections. Cefuroxime kills bacteria by inhibiting cell wall synthesis, while Clavulanic Acid prevents bacterial resistance by inhibiting beta-lactamase enzymes.
- Generic Name: Cefuroxime + Clavulanic Acid
- Manufacturer: Cosmic Life Sciences
- Form: Allopathy
- Pregnancy Category: B
- Prescription Required: Yes
๐ axeclav 500mg/125mg tablet Uses & Benefits
Upper and lower respiratory tract infections, urinary tract infections, skin and soft tissue infections, otitis media, sinusitis, bone and joint infections.
Off-label uses: Lyme disease, gonorrhea, surgical prophylaxis (oral form not typically used).
๐ Drug Information
| Generic Name(s) | Cefuroxime + Clavulanic Acid |
| Brand Name | Augxetil CV 500 Tablet |
| Manufacturer | Cosmic Life Sciences |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Cephalosporin antibiotic + Beta-lactamase inhibitor |
| Route of Administration | Oral |
| Storage | Store at room temperature (20-25ยฐC); protect from moisture and light. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Cefuroxime inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs); Clavulanic acid irreversibly inhibits beta-lactamases, preventing degradation of cefuroxime.
Mechanism Steps
๐ก How to Take axeclav 500mg/125mg tablet
Follow your doctor's prescription exactly.
Dosage Timeline
โ ๏ธ Side Effects of axeclav 500mg/125mg tablet
โ Common Side Effects
- Diarrhea
- Nausea
- Vomiting
- Rash
- Injection site pain (if IV)
๐จ Serious Side Effects
- Severe allergic reactions
- Clostridioides difficile colitis
- Seizures
- Stevens-Johnson syndrome
โ ๏ธ Rare Side Effects
- Hemolytic anemia
- Interstitial nephritis
- Hepatitis
- Agranulocytosis
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | Increased bleeding risk |
| Methotrexate | Moderate | Increased methotrexate toxicity |
| Probenecid | Moderate | Decreased renal excretion of cefuroxime |
๐จ Major Interactions
- Warfarin
- Methotrexate
- Probenecid
- Live vaccines
โก Moderate Interactions
- Oral contraceptives
- Loop diuretics
- Aminoglycosides
โน๏ธ Minor Interactions
- Antacids
- H2 receptor antagonists
๐ฝ๏ธ Food Interactions
Food increases absorption; take with food to enhance bioavailability.
๐ท Alcohol Interaction
No direct interaction, but alcohol may increase side effects like dizziness.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to cephalosporins or beta-lactamase inhibitors; history of anaphylaxis to penicillins.
๐ Monitoring Parameters
Renal function, liver function, CBC, signs of superinfection or allergic reactions.
๐คฑ Lactation Safety
Excreted in breast milk in small amounts; use with caution.
๐ Overdose Management
Supportive care; hemodialysis may enhance elimination.
โฐ Missed Dose
Take as soon as remembered; if near next dose, skip missed dose. Do not double dose.
๐จโโ๏ธ Reviewed by Expert
โญ User Reviews
Helpful and effective medicine as per my experience. Always consult a doctor.
This medicine was effective for me. I followed the doctor's advice.
Effective and reliable. Worked as expected.
Helpful and effective medicine as per my experience. Always consult a doctor.
Helpful and effective medicine as per my experience. Always consult a doctor.