axces th tablet - Uses, Price, Side Effects & Substitutes
What is axces th tablet used for?
Alock E TH 60mg/4mg Tablet (Etoricoxib + Thiocolchicoside) is used to treat PAIN ANALGESICS. It contains Etoricoxib (60mg) + Thiocolchicoside (4mg), which Etoricoxib selectively inhibits COX-2, reducing prostaglandin synthesis; Thiocol. Always consult your doctor before use. Take as prescribed.
- Generic Name: Etoricoxib + Thiocolchicoside
- Manufacturer: Aurz Pharmaceuticals Pvt Ltd
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ axces th tablet Uses & Benefits
Acute musculoskeletal pain, osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, muscle spasms.
Off-label uses: Chronic low back pain, fibromyalgia (limited evidence).
๐ Drug Information
| Generic Name(s) | Etoricoxib + Thiocolchicoside |
| Brand Name | Alock E TH 60mg/4mg Tablet |
| Manufacturer | Aurz Pharmaceuticals Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | NSAID + Muscle Relaxant |
| Route of Administration | Oral |
| Storage | Store at room temperature (20-25ยฐC), protect from moisture and light. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Etoricoxib selectively inhibits COX-2, reducing prostaglandin synthesis; Thiocolchicoside acts as a GABA-A receptor agonist and glycine receptor agonist, producing muscle relaxation.
Mechanism Steps
๐ก How to Take axces th tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of axces th tablet
โ Common Side Effects
- Nausea
- Dyspepsia
- Diarrhea
- Headache
- Dizziness
- Somnolence
๐จ Serious Side Effects
- GI bleeding
- Cardiovascular events (MI, stroke)
- Hepatotoxicity
- Renal failure
- Anaphylaxis
โ ๏ธ Rare Side Effects
- Stevens-Johnson syndrome
- Toxic epidermal necrolysis
- Aplastic anemia
- Seizures
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | Increased bleeding risk |
| Methotrexate | Major | Increased methotrexate toxicity |
| Lithium | Major | Increased lithium levels and toxicity |
| ACE inhibitors | Major | Reduced antihypertensive effect |
| Diuretics | Major | Reduced diuretic effect, increased nephrotoxicity |
| Aspirin | Major | Increased GI bleeding risk |
| Ketoconazole | Moderate | Increased etoricoxib levels |
| Rifampin | Moderate | Decreased etoricoxib levels |
| Antacids | Minor | Slight decrease in absorption |
๐จ Major Interactions
- Warfarin
- Methotrexate
- Lithium
- ACE inhibitors
- Diuretics
- Aspirin
โก Moderate Interactions
- CYP3A4 inhibitors (e.g., ketoconazole)
- CYP3A4 inducers (e.g., rifampin)
- Anticoagulants
- Antiplatelets
โน๏ธ Minor Interactions
- Antacids
- Corticosteroids
๐ฝ๏ธ Food Interactions
Food may delay absorption of etoricoxib but does not affect extent; thiocolchicoside absorption unaffected.
๐ท Alcohol Interaction
Increased risk of gastrointestinal bleeding and hepatotoxicity.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity, pregnancy, breastfeeding, severe hepatic/renal impairment, active peptic ulcer, history of asthma, CV disease (etoricoxib), myasthenia gravis (thiocolchicoside).
๐ Monitoring Parameters
Liver function, renal function, blood pressure, signs of GI bleeding, cardiovascular status.
๐คฑ Lactation Safety
Not recommended; both drugs excreted in breast milk.
๐ Overdose Management
Symptomatic and supportive; no specific antidote. Induce emesis or gastric lavage if recent.
โฐ Missed Dose
Take as soon as remembered; skip if almost time for next dose. Do not double dose.