Avonim-P Tablet - Uses, Price, Side Effects, Dosage
What is avonim-p tablet used for?
Avonim-P Tablet is a combination of Nimesulide (100mg) and Paracetamol (500mg) used to relieve pain and reduce fever. Nimesulide works by blocking COX-2 enzymes, reducing inflammation, while Paracetamol acts on the brain to lower fever and pain perception. It is commonly used for headaches, dental pain, menstrual cramps, and musculoskeletal pain.
- Generic Name: Nimesulide + Paracetamol
- Manufacturer: Avita Laboratories Pvt Ltd
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ avonim-p tablet Uses & Benefits
๐ Drug Information
| Generic Name(s) | Nimesulide + Paracetamol |
| Brand Name | AP 100mg/325mg Tablet |
| Manufacturer | Avita Laboratories Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | Nonsteroidal Anti-inflammatory Drug (NSAID) + Analgesic/Antipyretic |
| Route of Administration | Oral |
| Storage | Store at room temperature (20-25ยฐC), protect from moisture |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Nimesulide selectively inhibits COX-2, reducing prostaglandin synthesis; Paracetamol inhibits COX in the CNS, reducing pain and fever
Mechanism Steps
๐ก How to Take avonim-p tablet
Follow your doctor's prescription exactly.
Dosage Timeline
โ ๏ธ Side Effects of avonim-p tablet
โ Common Side Effects
- Nausea
- Vomiting
- Dizziness
- Somnolence
- Diarrhea
๐จ Serious Side Effects
- Hepatotoxicity
- Gastrointestinal bleeding
- Stevens-Johnson syndrome
- Renal failure
โ ๏ธ Rare Side Effects
- Agranulocytosis
- Anaphylaxis
- Pancreatitis
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | Increased bleeding risk |
| Methotrexate | Major | Increased methotrexate toxicity |
| Aspirin | Moderate | Increased risk of gastrointestinal bleeding |
| ACE inhibitors | Moderate | Reduced antihypertensive effect |
๐จ Major Interactions
- Warfarin
- Methotrexate
- Lithium
- Aspirin
- Other NSAIDs
โก Moderate Interactions
- ACE inhibitors
- Diuretics
- Anticoagulants
- Corticosteroids
โน๏ธ Minor Interactions
- Antacids
- Cholestyramine
๐ฝ๏ธ Food Interactions
Food may delay absorption; avoid alcohol
๐ท Alcohol Interaction
Increased risk of hepatotoxicity and gastrointestinal bleeding
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity, active peptic ulcer, severe hepatic/renal impairment, third trimester pregnancy, lactation, children <12 years (Nimesulide)
๐ Monitoring Parameters
Liver function, renal function, blood pressure, signs of bleeding
๐คฑ Lactation Safety
Paracetamol is safe; Nimesulide is contraindicated
๐ Overdose Management
Activated charcoal, N-acetylcysteine for paracetamol overdose; supportive care
โฐ Missed Dose
Take as soon as remembered; skip if near next dose; do not double dose