avoflox 400mg tablet - Ofloxacin (400mg) medicine

Avoflox 400mg Tablet - Uses, Price, Side Effects

4.5 (14 reviews)
๐Ÿญ Tenet Healthcare ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Aug 22, 2026
๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
SaathiMed Expert Panel | Aug 22, 2026

What is avoflox 400mg tablet used for?

Avoflox 400mg Tablet contains Ofloxacin, a fluoroquinolone antibiotic that works by inhibiting bacterial DNA gyrase and topoisomerase IV, thereby stopping bacterial replication. It is used to treat various bacterial infections including respiratory tract infections, urinary tract infections, skin infections, and sexually transmitted diseases.

  • Generic Name: Ofloxacin
  • Manufacturer: Tenet Healthcare
  • Form: Allopathy
  • Pregnancy Category: C
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

๐Ÿ’Š avoflox 400mg tablet Uses & Benefits

Bacterial conjunctivitis, keratitis, blepharitis, dacryocystitis

Off-label uses: Corneal ulcers, Prophylaxis in ocular surgery

๐Ÿ“‹ Drug Information

Generic Name(s)Ofloxacin
Brand NameAuroflox 0.3% Eye Drop
ManufacturerTenet Healthcare
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassANTI INFECTIVES
Action ClassQuinolones/ Fluroquinolones
Route of AdministrationOphthalmic (topical)
StorageStore at 15-25ยฐC, protect from light, keep tightly closed
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionMinimal systemic absorption after ocular administration
DistributionDistributes into ocular tissues; negligible systemic distribution
Protein BindingApproximately 20-32%
MetabolismHepatic metabolism (limited systemic)
Half-Life4-5 hours (systemic); ocular half-life not well defined
ExcretionRenal (systemic); minimal ocular excretion
BioavailabilityLow systemic bioavailability due to topical administration
Onset of ActionRapid; within 30 minutes
Peak Plasma TimeNot applicable for topical use; systemic peak at 1-2 hours if absorbed
Duration of ActionApproximately 4-6 hours

How It Works

Inhibits bacterial DNA gyrase and topoisomerase IV, preventing DNA replication and transcription

Mechanism Steps

1Ofloxacin enters bacterial cell through porin channels
2Binds to DNA gyrase (subunit A) and topoisomerase IV
3Inhibits supercoiling and DNA replication

๐Ÿ’ก How to Take avoflox 400mg tablet

Follow your doctor's prescription exactly.

Dosage Timeline

๐ŸŒ… Morning โœ… โ˜€๏ธ Afternoon โŒ ๐ŸŒ† Evening โœ… ๐ŸŒ™ Night โŒ

โš ๏ธ Side Effects of avoflox 400mg tablet

โœ… Common Side Effects

  • Eye irritation
  • Stinging
  • Blurred vision
  • Taste perversion

๐Ÿšจ Serious Side Effects

  • Corneal perforation
  • Anaphylaxis
  • Tendon rupture (rare with topical)

โš ๏ธ Rare Side Effects

  • Stevens-Johnson syndrome
  • Peripheral neuropathy
  • QT prolongation

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
Warfarin Major Increased bleeding risk
NSAIDs Moderate Increased risk of CNS stimulation and seizures
Antacids Moderate Reduced absorption of Ofloxacin

๐Ÿšจ Major Interactions

  • Warfarin
  • NSAIDs
  • Antidiabetic agents
  • Corticosteroids

โšก Moderate Interactions

  • Cyclosporine
  • Methotrexate
  • Theophylline

โ„น๏ธ Minor Interactions

  • Cimetidine
  • Probenecid

๐Ÿฝ๏ธ Food Interactions

No significant food interactions for ophthalmic use

๐Ÿท Alcohol Interaction

No known interaction

๐Ÿ›ก๏ธ Safety & Warnings

Liver
Low
Kidney
Low
Heart
Low
Pregnancy
Category C

๐Ÿšซ Contraindications

Hypersensitivity to ofloxacin or any quinolone

๐Ÿ“Š Monitoring Parameters

Clinical improvement, signs of hypersensitivity, corneal status

๐Ÿคฑ Lactation Safety

Caution; excreted in breast milk in small amounts

๐Ÿ’Š Overdose Management

Flush eye with water; supportive care if ingested

โฐ Missed Dose

Apply as soon as remembered; skip if almost time for next dose

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 22, 2026

๐Ÿ”— View Profile

๐Ÿ”„ Substitutes for avoflox 400mg tablet

View All

Alternative brands with exact same active ingredient (Ofloxacin (400mg)):

Medical Note: Always consult your doctor before switching medications.

โญ User Reviews

Trusted Reviewer Jul 10, 2026

Found this to be a helpful product. Good results.

Regular Customer Jul 10, 2026

This medicine was effective for me. I followed the doctor's advice.

Happy Patient Jul 10, 2026

This medicine was effective for me. I followed the doctor's advice.

Regular Customer Jul 10, 2026

Good quality medicine. Satisfied with the outcome.

Happy Patient Jul 10, 2026

This medicine was effective for me. I followed the doctor's advice.

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