avibose mf 500 mg/0.3 mg tablet - Uses, Price, Side Effects & Substitutes
What is avibose mf 500 mg/0.3 mg tablet used for?
Advog M 0.3 Plus Tablet (Metformin + Voglibose) is used to treat ANTI DIABETIC. It contains Metformin (500mg) + Voglibose (0.3mg), which Metformin decreases hepatic glucose production and increases insulin sensitivity. Always consult your doctor before use. Take as prescribed.
- Generic Name: Metformin + Voglibose
- Manufacturer: Avinash Health Products Pvt Ltd
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ avibose mf 500 mg/0.3 mg tablet Uses & Benefits
Type 2 diabetes mellitus, especially for postprandial hyperglycemia.
Off-label uses: Polycystic ovary syndrome (metformin alone), prevention of diabetes.
๐ Drug Information
| Generic Name(s) | Metformin + Voglibose |
| Brand Name | Advog M 0.3 Plus Tablet |
| Manufacturer | Avinash Health Products Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI DIABETIC |
| Action Class | Antidiabetic |
| Route of Administration | Oral |
| Storage | Store at room temperature (20-25ยฐC), protect from moisture. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Metformin decreases hepatic glucose production and increases insulin sensitivity; Voglibose inhibits alpha-glucosidase, delaying carbohydrate absorption.
Mechanism Steps
๐ก How to Take avibose mf 500 mg/0.3 mg tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of avibose mf 500 mg/0.3 mg tablet
โ Common Side Effects
- Gastrointestinal discomfort
- Diarrhea
- Nausea
- Flatulence
- Abdominal bloating
๐จ Serious Side Effects
- Lactic acidosis
- Hypoglycemia
- Pancreatitis
- Vitamin B12 deficiency
โ ๏ธ Rare Side Effects
- Metallic taste
- Skin reactions
- Hepatitis
- Pneumonitis
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Contrast media | Major | Increased risk of lactic acidosis; discontinue metformin before procedure. |
| Cimetidine | Major | Reduced metformin clearance. |
| Carbonic anhydrase inhibitors | Major | Increased risk of lactic acidosis. |
| Topiramate | Major | Increased risk of metabolic acidosis. |
| Insulin | Moderate | Enhanced hypoglycemic effect. |
| Sulfonylureas | Moderate | Increased risk of hypoglycemia. |
| NSAIDs | Moderate | Reduced renal function may increase metformin levels. |
| ACE inhibitors | Moderate | Enhanced hypoglycemic effect. |
| Furosemide | Minor | Increased metformin plasma concentration. |
| Nifedipine | Minor | Increased metformin absorption. |
| Amiloride | Minor | Increased metformin plasma concentration. |
๐จ Major Interactions
- Contrast media
- Cimetidine
- Carbonic anhydrase inhibitors
- Topiramate
โก Moderate Interactions
- Insulin
- Sulfonylureas
- NSAIDs
- ACE inhibitors
โน๏ธ Minor Interactions
- Furosemide
- Nifedipine
- Amiloride
๐ฝ๏ธ Food Interactions
Alcohol, High carbohydrate meals
๐ท Alcohol Interaction
Increased risk of lactic acidosis with metformin; avoid excessive alcohol.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Renal impairment (eGFR <30 mL/min), metabolic acidosis, diabetic ketoacidosis, hypersensitivity, severe hepatic impairment, gastrointestinal obstruction.
๐ Monitoring Parameters
Blood glucose, HbA1c, renal function (eGFR), liver function, lactic acid levels if symptoms.
๐คฑ Lactation Safety
Metformin is excreted in milk; Voglibose is not absorbed; caution advised.
๐ Overdose Management
Supportive care; monitor blood glucose and lactate; hemodialysis may remove metformin.
โฐ Missed Dose
Take as soon as remembered unless near next dose; skip missed dose if next dose is due.