atorfit d 10mg/1000iu tablet - Atorvastatin (10mg) + Vitamin D3 (1000IU) medicine

Atorfit D 10mg/1000IU Tablet - Uses, Price, Side Effects

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🏭 Ajanta Pharma Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 23, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Reviewed by
SaathiMed Expert Panel | Sep 23, 2026

What is atorfit d 10mg/1000iu tablet used for?

Atorfit D 10mg/1000IU Tablet is a combination of Atorvastatin (10mg) and Vitamin D3 (1000IU). Atorvastatin lowers bad cholesterol and triglycerides, reducing heart attack and stroke risk. Vitamin D3 supports bone health and immune function. It is used in patients with high cholesterol and vitamin D deficiency.

  • Generic Name: Atorvastatin + Vitamin D3
  • Manufacturer: Ajanta Pharma Ltd
  • Form: Allopathy
  • Pregnancy Category: Category A
  • Prescription Required: Yes
💡 Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

💊 atorfit d 10mg/1000iu tablet Uses & Benefits

Primary hypercholesterolemia, mixed dyslipidemia, homozygous familial hypercholesterolemia, prevention of cardiovascular events, vitamin D deficiency or insufficiency.

Off-label uses: Polycystic ovary syndrome (PCOS), non-alcoholic fatty liver disease (NAFLD), prevention of contrast-induced nephropathy (atorvastatin), osteoporosis (vitamin D3).

📋 Drug Information

Generic Name(s)Atorvastatin + Vitamin D3
Brand NameAtorsave D 10 Tablet
ManufacturerAjanta Pharma Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassCARDIAC
Action ClassHMG-CoA reductase inhibitor (statin) with vitamin D supplementation
Route of AdministrationOral
StorageStore at room temperature (20-25°C), protect from light and moisture.
Shelf LifeAs per manufacturer

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionAtorvastatin is rapidly absorbed after oral administration; peak plasma concentrations occur within 1-2 hours. Vitamin D3 is well absorbed in the small intestine.
DistributionAtorvastatin is highly distributed to tissues; vitamin D3 is distributed to fat and muscle tissues.
Protein BindingAtorvastatin: ≥98% bound to plasma proteins. Vitamin D3: bound to vitamin D-binding protein.
MetabolismAtorvastatin: extensively metabolized by CYP3A4 to active ortho- and para-hydroxylated metabolites. Vitamin D3: hydroxylated in liver to 25-hydroxyvitamin D3.
Half-LifeAtorvastatin: approximately 14 hours (parent drug); active metabolites: 20-30 hours. Vitamin D3: 2-3
ExcretionAtorvastatin: primarily biliary excretion (feces); less than 2% excreted in urine. Vitamin D3: excreted in bile and feces.
BioavailabilityAtorvastatin: approximately 14% (low due to first-pass metabolism). Vitamin D3: well absorbed.
Onset of ActionAtorvastatin: within 2 weeks for lipid-lowering effect. Vitamin D3: variable.
Peak Plasma TimeAtorvastatin: 1-2 hours. Vitamin D3: 12-24 hours.
Duration of ActionAtorvastatin: up to 24 hours (once-daily dosing). Vitamin D3: weeks to months.

How It Works

Atorvastatin competitively inhibits HMG-CoA reductase, reducing cholesterol synthesis; increases LDL receptor expression. Vitamin D3 enhances calcium absorption and bone mineralization.

Mechanism Steps

1Atorvastatin competitively inhibits HMG-CoA reductase, the rate-limiting enzyme in cholesterol biosynthesis.
2Reduced intracellular cholesterol leads to upregulation of LDL receptors on hepatocytes.
3Increased LDL receptor expression enhances clearance of LDL-C from plasma.
4Atorvastatin also reduces VLDL synthesis and secretion.
5Vitamin D3 is converted to 25-hydroxyvitamin D3 in the liver.
625-hydroxyvitamin D3 is further hydroxylated in the kidney to active 1,25-dihydroxyvitamin D3.
7Active vitamin D binds to vitamin D receptor (VDR) in target tissues.
8VDR activation regulates gene expression involved in calcium and phosphate homeostasis.

💡 How to Take atorfit d 10mg/1000iu tablet

Follow your doctor's prescription exactly.

Dosage Timeline

🌅 Morning ✅ ☀️ Afternoon ❌ 🌆 Evening ✅ 🌙 Night ❌

⚠️ Side Effects of atorfit d 10mg/1000iu tablet

✅ Common Side Effects

Nasopharyngitis
Arthralgia
Diarrhea
Pain in extremity
Urinary tract infection
Dyspepsia
Nausea
Musculoskeletal pain

🚨 Serious Side Effects

Rhabdomyolysis
Myopathy
Hepatotoxicity (elevated transaminases, jaundice)
Hypersensitivity reactions (angioedema, Stevens-Johnson syndrome)
New-onset diabetes mellitus
Hemorrhagic stroke (in patients with prior stroke)

⚠️ Rare Side Effects

Interstitial lung disease
Peripheral neuropathy
Memory loss
Confusion
Gynecomastia
Tendon rupture
Immune-mediated necrotizing myopathy

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major Increased bleeding risk
Cyclosporine Major Increased risk of myopathy/rhabdomyolysis
Gemfibrozil Major Increased risk of myopathy/rhabdomyolysis
Digoxin Moderate Increased digoxin levels
Antacids Minor Reduced absorption of atorvastatin

🚨 Major Interactions

  • CYP3A4 inhibitors (e.g., itraconazole, ketoconazole, erythromycin, clarithromycin, telithromycin, HIV protease inhibitors, nefazodone)
  • Cyclosporine
  • Gemfibrozil
  • Other fibrates
  • Niacin (≥1 g/day)
  • Colchicine
  • Rifampin
  • Digoxin
  • Oral contraceptives

⚡ Moderate Interactions

  • Warfarin
  • Antacids
  • Colestipol
  • Colesevelam
  • Fenofibrate
  • Ezetimibe
  • Amiodarone
  • Verapamil
  • Diltiazem
  • Grapefruit juice

🍷 Alcohol Interaction

Excessive alcohol consumption may increase risk of hepatotoxicity.

🛡️ Safety & Warnings

🚫 Contraindications

Active liver disease, unexplained persistent elevations of serum transaminases, pregnancy, lactation, hypersensitivity to atorvastatin or vitamin D3, concomitant use with strong CYP3A4 inhibitors (e.g., itraconazole, ketoconazole, HIV protease inhibitors).

🤱 Lactation Safety

Atorvastatin is excreted in breast milk; not recommended during breastfeeding. Vitamin D3 is safe.

💊 Overdose Management

No specific antidote; symptomatic and supportive care; monitor liver function and CK levels; consider gastric lavage if recent ingestion.

⏰ Missed Dose

Take missed dose as soon as remembered; if close to next dose, skip missed dose; do not double dose.

🔄 Substitutes for atorfit d 10mg/1000iu tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

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