atoin c gel - Clindamycin (1% w/w) + Tretinoin (0.025% w/w) medicine

Atoin C Gel - Uses, Price, Side Effects

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๐Ÿญ Canbro Healthcare ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Jun 29, 2026
๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
SaathiMed Expert Panel | Jun 29, 2026

What is atoin c gel used for?

Atoin C Gel is a combination medicine used to treat acne vulgaris. It contains Clindamycin, an antibiotic that kills acne-causing bacteria, and Tretinoin, a retinoid that unclogs pores and promotes skin renewal. Apply a thin layer once daily at night.

  • Generic Name: Clindamycin + Tretinoin
  • Manufacturer: Canbro Healthcare
  • Form: Allopathy
  • Pregnancy Category: C
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? The Indian pharmaceutical market is expected to reach $130 billion by 2030.

๐Ÿ’Š atoin c gel Uses & Benefits

Acne vulgaris, comedonal acne, inflammatory acne.

Off-label uses: Rosacea, Photodamage

๐Ÿ“‹ Drug Information

Generic Name(s)Clindamycin + Tretinoin
Brand NameAcsolve C Gel
ManufacturerCanbro Healthcare
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassDERMA
Action ClassAntibiotic + Retinoid
Route of AdministrationTopical
StorageStore at 20-25ยฐC (68-77ยฐF); protect from light.
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionTopical absorption is minimal; systemic absorption is low.
DistributionDistributes locally in skin; negligible systemic distribution.
Protein BindingClindamycin: ~94% bound to plasma proteins; Tretinoin: >95% bound.
MetabolismClindamycin: Hepatic metabolism via CYP3A4; Tretinoin: Hepatic metabolism via CYP450.
Half-LifeClindamycin: ~2-3 hours; Tretinoin: ~0.5-2 hours.
ExcretionClindamycin: Renal and biliary; Tretinoin: Renal and fecal.
BioavailabilityLow systemic bioavailability due to topical application.
Onset of ActionWithin 2-4 weeks of regular use.
Peak Plasma TimeNot applicable for topical use.
Duration of ActionSustained with regular application.

How It Works

Clindamycin inhibits bacterial protein synthesis; Tretinoin normalizes follicular keratinization.

Mechanism Steps

1Clindamycin binds to 50S ribosomal subunit of bacteria, inhibiting protein synthesis.
2Tretinoin binds to retinoic acid receptors in skin cells, modulating gene expression.
3Reduces follicular keratinocyte proliferation and differentiation.

๐Ÿ’ก How to Take atoin c gel

Follow your doctor's prescription exactly.

Dosage Timeline

๐ŸŒ… Morning โœ… โ˜€๏ธ Afternoon โŒ ๐ŸŒ† Evening โŒ ๐ŸŒ™ Night โœ…

โš ๏ธ Side Effects of atoin c gel

โœ… Common Side Effects

  • Skin dryness
  • Peeling
  • Erythema
  • Burning sensation

๐Ÿšจ Serious Side Effects

  • Pseudomembranous colitis
  • Severe allergic reactions

โš ๏ธ Rare Side Effects

  • Contact dermatitis
  • Hyperpigmentation

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
Erythromycin Major Antagonism of clindamycin effect
Neuromuscular blocking agents Major Enhanced neuromuscular blockade
Oral contraceptives Moderate Reduced efficacy of contraceptive
Corticosteroids Moderate Increased skin irritation
Benzoyl peroxide Minor Possible oxidation of tretinoin
Salicylic acid Minor Increased skin dryness

๐Ÿšจ Major Interactions

  • Erythromycin
  • Neuromuscular blocking agents

โšก Moderate Interactions

  • Oral contraceptives
  • Corticosteroids

โ„น๏ธ Minor Interactions

  • Benzoyl peroxide
  • Salicylic acid

๐Ÿฝ๏ธ Food Interactions

No significant food interactions.

๐Ÿท Alcohol Interaction

No known interaction.

๐Ÿ›ก๏ธ Safety & Warnings

Liver
Low
Kidney
Low
Heart
Low
Pregnancy
Category C

๐Ÿšซ Contraindications

Hypersensitivity to any component, history of enteritis, colitis, or antibiotic-associated colitis.

๐Ÿ“Š Monitoring Parameters

Skin irritation, therapeutic response, signs of infection.

๐Ÿคฑ Lactation Safety

Use with caution; limited data.

๐Ÿ’Š Overdose Management

Topical overdose unlikely; if ingested, symptomatic treatment.

โฐ Missed Dose

Apply as soon as remembered; skip if almost time for next dose.

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Reviewed: Jun 29, 2026

๐Ÿ”— View Profile

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