atazor 300 capsule - Uses, Price, Side Effects & Substitutes
What is atazor 300 capsule used for?
Atazor 200mg Capsule (Atazanavir) is used to treat ANTI INFECTIVES. It contains Atazanavir (300mg), which Inhibits HIV-1 protease, preventing cleavage of viral polyproteins and maturatio. Always consult your doctor before use. Take as prescribed.
- Generic Name: Atazanavir
- Manufacturer: Emcure Pharmaceuticals Ltd
- Form: Allopathy
- Pregnancy Category: B
- Prescription Required: Yes
๐ atazor 300 capsule Uses & Benefits
Treatment of HIV-1 infection in combination with other antiretroviral agents.
Off-label uses: Not typically used off-label; investigational for COVID-19 (not recommended).
๐ Drug Information
| Generic Name(s) | Atazanavir |
| Brand Name | Atazor 200mg Capsule |
| Manufacturer | Emcure Pharmaceuticals Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Protease (HIV) inhibitors |
| Route of Administration | Oral |
| Storage | Store at 20-25ยฐC (68-77ยฐF); protect from moisture. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Inhibits HIV-1 protease, preventing cleavage of viral polyproteins and maturation of infectious virions.
Mechanism Steps
๐ก How to Take atazor 300 capsule
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of atazor 300 capsule
โ Common Side Effects
- Nausea
- Jaundice/scleral icterus
- Headache
- Diarrhea
- Abdominal pain
- Insomnia
๐จ Serious Side Effects
- Hepatotoxicity
- Nephrolithiasis
- PR interval prolongation
- Rash (Stevens-Johnson syndrome rare)
- Hyperbilirubinemia
โ ๏ธ Rare Side Effects
- Cholelithiasis
- Pancreatitis
- Peripheral neuropathy
- Diabetes mellitus
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Rifampin | Major | Significant decrease in atazanavir concentrations, leading to loss of virologic response. |
| St. John's Wort | Major | Reduces atazanavir plasma concentrations. |
| Nevirapine | Major | Decreases atazanavir exposure. |
| Tipranavir/ritonavir | Major | Decreases atazanavir concentrations. |
| Bosentan | Major | Decreases atazanavir concentrations. |
| Warfarin | Moderate | Increased bleeding risk due to altered warfarin metabolism. |
| Oral contraceptives | Moderate | Decreased efficacy of oral contraceptives; alternative contraception recommended. |
| Atorvastatin | Moderate | Increased risk of myopathy/rhabdomyolysis; monitor or use alternative statin. |
| Sildenafil | Moderate | Increased sildenafil exposure; risk of hypotension, priapism. |
| Tadalafil | Moderate | Increased tadalafil exposure; risk of adverse effects. |
| Methadone | Minor | No significant interaction; monitor for methadone withdrawal. |
| Buprenorphine | Minor | No significant interaction. |
| Antacids | Minor | Reduced atazanavir absorption; separate by at least 2 hours. |
| H2-receptor antagonists | Minor | Reduced atazanavir absorption; separate by at least 10 hours. |
๐จ Major Interactions
- Rifampin
- St. John's Wort
- Nevirapine
- Tipranavir/ritonavir
- Bosentan
โก Moderate Interactions
- Warfarin
- Oral contraceptives
- Atorvastatin
- Sildenafil
- Tadalafil
โน๏ธ Minor Interactions
- Methadone
- Buprenorphine
- Antacids
- H2-receptor antagonists
๐ฝ๏ธ Food Interactions
Take with food to enhance absorption; avoid taking with antacids or buffered medications.
๐ท Alcohol Interaction
No specific interaction; may increase hepatotoxicity risk in patients with liver disease.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to atazanavir; co-administration with drugs highly dependent on CYP3A4 for clearance (e.g., rifampin, St. John's Wort, nevirapine, tipranavir/ritonavir, bosentan).
๐ Monitoring Parameters
HIV viral load, CD4 count, liver function tests, bilirubin, ECG (if pre-existing conduction disease).
๐คฑ Lactation Safety
Not recommended; HIV-infected mothers should not breastfeed to avoid transmission.
๐ Overdose Management
No specific antidote; supportive care including monitoring of vital signs and ECG.
โฐ Missed Dose
If missed within 6 hours of usual time, take with food; if >6 hours, skip and resume next dose.
๐จโโ๏ธ Reviewed by Expert
๐ Substitutes for atazor 300 capsule
View AllAlternative brands with exact same active ingredient (Atazanavir (300mg)):
-
virataz 300mg capsuleHetero Drugs Ltd โน2,100.00 0.6% CHEAPER
-
atavir 300mg capsuleCipla Ltd โน2,300.00 8.9% COSTLIER
Medical Note: Always consult your doctor before switching medications.