Anxifree Tablet: Complete Guide to Uses, Side Effects, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Irregular or rapid heartbeat, palpitations, or fainting
- High fever with muscle rigidity, confusion, or agitation
- Severe allergic reaction: rash, swelling of face/lips/throat, difficulty breathing
- Signs of serotonin syndrome: sweating, tremor, diarrhea, fever, confusion
- Involuntary movements of face, tongue, or limbs
- Yellowing of skin or eyes, dark urine, severe abdominal pain
- Worsening depression or new suicidal thoughts
If experiencing severe symptoms, call emergency services immediately.
What is astexit tablet used for?
This medicine is a combination of flupenthixol (an antipsychotic) and escitalopram (an antidepressant) used to treat severe depression with psychotic features or anxiety. It works by blocking dopamine receptors and increasing serotonin levels in the brain. It is available as an oral tablet and must be taken under medical supervision.
- Generic Name: Flupenthixol + Escitalopram
- Manufacturer: Aster Medipharm Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 astexit tablet के बारे में (Hindi Summary)
उपयोग: यह दवा फ्लूपेंथिक्सोल और एस्सिटालोप्राम का संयोजन है, जिसका उपयोग गंभीर अवसाद (डिप्रेशन) के इलाज के लिए किया जाता है, खासकर जब मतिभ्रम या अत्यधिक बेचैनी जैसे लक्षण भी मौजूद हों। यह मस्तिष्क में डोपामिन और सेरोटोनिन के स्तर को संतुलित करके काम करती है। यह दवा केवल डॉक्टर की सलाह पर ही लेनी चाहिए और बिना पूछे बंद नहीं करनी चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मुँह सूखना, नींद आना, चक्कर आना, थकान, वजन बढ़ना और यौन समस्याएँ शामिल हैं। गंभीर दुष्प्रभावों में दिल की धड़कन अनियमित होना, बुखार, मांसपेशियों में अकड़न, भ्रम, और सेरोटोनिन सिंड्रोम के लक्षण जैसे पसीना आना और कंपन शामिल हैं। अगर ऐसे लक्षण दिखें तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसे अचानक बंद न करें, क्योंकि इससे withdrawal के लक्षण हो सकते हैं। शराब और नशीले पदार्थों से बचें। गाड़ी चलाने या मशीन चलाने से बचें जब तक कि आपको इस दवा का असर पता न चल जाए। अगर आप गर्भवती हैं, स्तनपान करा रही हैं, या कोई अन्य दवा ले रही हैं, तो डॉक्टर को बताएं। नियमित जांच और फॉलो-अप जरूरी है।
💊 astexit tablet Uses & Benefits
[{"condition":"Major depressive disorder with psychotic features","description":"This combination is used to treat severe depression accompanied by delusions, hallucinations, or severe agitation.","evidence":"Limited evidence from clinical practice; combination not widely studied in randomized trials."},{"condition":"Treatment-resistant depression","description":"May be prescribed when other antidepressants have failed, especially if psychotic symptoms are present.","evidence":"Limited evidence; use is based on clinical experience."},{"condition":"Depression with prominent anxiety","description":"The escitalopram component addresses anxiety symptoms while flupenthixol may help with agitation.","evidence":"Limited evidence for the combination; individual components are well-established."}]
Off-label uses: [{"condition":"Schizoaffective disorder","description":"Sometimes used off-label for mood symptoms in schizoaffective disorder.","evidence":"Limited"},{"condition":"Severe agitation in dementia","description":"Not recommended due to increased risk of stroke and mortality in elderly patients with dementia.","evidence":"Not recommended"}]
Primary treatment for: Major depressive disorder with psychotic features
Also treats: Treatment-resistant depression, Depression with anxiety, Schizoaffective disorder
📋 Drug Information
| Generic Name(s) | Flupenthixol + Escitalopram |
| Brand Name | Anxifree Tablet |
| Manufacturer | Aster Medipharm Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | Antipsychotic + SSRI |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with distinct mechanisms. Flupenthixol is a thioxanthene antipsychotic that blocks dopamine D1 and D2 receptors in the mesolimbic and mesocortical pathways, reducing psychotic symptoms and agitation. It also has some affinity for serotonin 5-HT2 receptors. Escitalopram is a selective serotonin reuptake inhibitor (SSRI) that binds to the serotonin transporter (SERT) and inhibits the reuptake of serotonin into presynaptic neurons, thereby increasing serotonin availability in the synaptic cleft. This enhancement of serotonergic neurotransmission is thought to underlie its antidepressant and anxiolytic effects. The combination aims to address both psychotic and mood symptoms simultaneously.
Mechanism Steps
💡 How to Take astexit tablet
Strength: Immediate-release oral tablet containing flupenthixol 0.5 mg and escitalopram oxalate 10 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet taken orally once daily, preferably at the same time each day. The dose may be adjusted by the doctor based on clinical response and tolerability. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the prescribed dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine. Start with a lower dose and titrate slowly. Close monitoring for side effects, especially cardiac and neurological, is recommended. |
| Renal Impairment | Dose adjustment may be required in patients with severe renal impairment. Consult a doctor for individualized dosing. |
| Hepatic Impairment | Dose adjustment is recommended in patients with hepatic impairment. Use with caution and monitor liver function. |
| Maximum Daily Dose | The maximum recommended daily dose is one tablet (flupenthixol 0.5 mg + escitalopram 10 mg). Do not exceed without medical advice. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of astexit tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| MAO inhibitors | Major | |
| QT-prolonging drugs | Major | |
| Other serotonergic drugs | Major | |
| CYP2C19 inhibitors | Major | |
| CNS depressants | Moderate | |
| Anticholinergics | Moderate | |
| Antihypertensives | Moderate | |
| NSAIDs | Moderate | |
| Antacids | Minor | |
| Caffeine | Minor |
🚨 Major Interactions
- MAO inhibitors (e.g., phenelzine, tranylcypromine)
- QT-prolonging drugs (e.g., amiodarone, sotalol, methadone)
- Other serotonergic drugs (e.g., triptans, tramadol, SSRIs, SNRIs)
- CYP2C19 inhibitors (e.g., omeprazole, fluconazole)
⚡ Moderate Interactions
- CNS depressants (e.g., benzodiazepines, opioids, alcohol)
- Anticholinergic drugs (e.g., benztropine, diphenhydramine)
- Antihypertensives
- NSAIDs
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine. It can increase central nervous system depression, leading to excessive drowsiness, dizziness, and impaired coordination. It may also worsen underlying depression and increase the risk of liver toxicity.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to flupenthixol, escitalopram, or any component of the formulation","Concurrent use of monoamine oxidase inhibitors (MAOIs) or within 14 days of stopping an MAOI","Known QT prolongation or congenital long QT syndrome","Severe liver impairment","Uncontrolled epilepsy","Pregnancy and breastfeeding unless clearly needed","Children and adolescents under 18 years"]
⚠️ Warnings & Precautions
["Increased risk of suicidal thoughts and behaviors, especially in young adults. Monitor closely.","May cause QT prolongation; avoid in patients with cardiac disease or electrolyte abnormalities.","Risk of neuroleptic malignant syndrome; discontinue immediately if symptoms occur.","May cause tardive dyskinesia with long-term use; monitor for involuntary movements.","Can cause serotonin syndrome; avoid concomitant serotonergic drugs.","May impair ability to drive or operate machinery; caution advised.","Avoid abrupt discontinuation to prevent withdrawal symptoms.","Use with caution in elderly patients with dementia due to increased risk of stroke and mortality.","May cause metabolic changes; monitor weight, glucose, and lipids.","Alcohol and CNS depressants should be avoided."]
🤱 Lactation Safety
Both flupenthixol and escitalopram are excreted in breast milk. There is limited information on the safety of this combination during breastfeeding. It is recommended to consult a doctor before breastfeeding while on this medicine.
💊 Overdose Management
Overdose of this medicine can cause severe drowsiness, tachycardia, QT prolongation, seizures, and serotonin syndrome. There is no specific antidote. Treatment is supportive and symptomatic, including gastric lavage if within 1-2 hours of ingestion, activated charcoal, ECG monitoring, and management of arrhythmias. Contact a poison control center or emergency department immediately.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
This medicine must be taken exactly as prescribed by your doctor. Do not stop or change the dose without medical advice, as abrupt discontinuation can cause withdrawal symptoms such as nausea, headache, and anxiety. Avoid alcohol and recreational drugs while taking this medicine, as they can worsen drowsiness and increase the risk of heart problems. Inform your doctor if you have a history of heart disease, seizures, liver or kidney problems, or if you are pregnant, planning pregnancy, or breastfeeding. Regular blood tests and heart monitoring (ECG) may be required. Do not drive or operate heavy machinery until you know how this medicine affects you. Keep all follow-up appointments and report any new or worsening symptoms immediately.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of side effects such as cardiac arrhythmias, falls, and metabolic changes. Lower doses and close monitoring are recommended. Avoid use in elderly with dementia due to increased risk of stroke and mortality.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor well in advance. This medicine may not be safe during pregnancy. Your doctor may switch you to a safer alternative or adjust the dose.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine. It may interact with anesthetic agents and affect heart rhythm. Your doctor may advise temporary discontinuation before surgery.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine. It may cause dry mouth, which can affect dental health. Also, it may interact with local anesthetics containing epinephrine, so your dentist should be aware.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Moderate exercise is generally safe, but avoid strenuous activities until you know how this medicine affects you, as it may cause drowsiness or dizziness. Stay hydrated and avoid overheating.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause drowsiness and dizziness, which may affect your ability to drive or operate machinery. It is advisable to avoid such activities until you know how the medicine affects you. Discuss with your employer if you need adjustments.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Your doctor will decide when and how to taper the dose based on your response and side effects. Abrupt discontinuation can cause withdrawal symptoms and relapse.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to metabolic changes such as weight gain, high blood sugar, and high cholesterol. It can also cause movement disorders like tardive dyskinesia. Regular monitoring of weight, blood glucose, lipids, and heart rhythm is recommended. Periodic assessment of the need for continued treatment is essential.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for depression and anxiety.
Evidence: Well-establishedConsidered for severe or treatment-resistant depression.
Evidence: Well-establishedNon-invasive brain stimulation for depression.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, consult your doctor before receiving any vaccine while on this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging along with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature and protect from extreme heat or cold. If crossing time zones, consult your doctor about adjusting the dosing schedule. Check local customs regulations for controlled substances.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: The antipsychotic effects may begin within a few days, but the antidepressant effects may take 1 to 2 weeks to become noticeable, with full benefits often taking 4 to 6 weeks.
A: No, you should not stop this medicine without consulting your doctor. Abrupt discontinuation can cause withdrawal symptoms and relapse of depression.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: The safety of this medicine during pregnancy is not well established. Consult your doctor if you are pregnant or planning pregnancy.
A: No, alcohol should be avoided as it can increase sedation, dizziness, and the risk of liver problems.
🤔 Common Patient Concerns
🔄 Substitutes for astexit tablet
View AllAlternative brands with exact same active ingredient:
-
esjoy-fp 0.5mg/10mg tabletGentech Healthcare Pvt Ltd ₹7.03 86.7% CHEAPER
-
dexit-e 0.5mg/10mg tabletDaksh Pharma Pvt Ltd ₹8.06 84.8% CHEAPER
-
Fuljoy 0.5mg/10mg TabletMan Serve Pharma ₹45.00 14.9% CHEAPER
-
celor f tabletOrganic Laboratories ₹59.06 11.6% COSTLIER
-
dexipra fx 0.5mg/10mg tabletCause & Cure Pvt Ltd ₹60.94 15.2% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is addictive.
Fact: This medicine is not considered addictive, but it can cause dependence and withdrawal symptoms if stopped abruptly. It should be tapered under medical supervision. - Myth: I can stop taking this medicine once I feel better.
Fact: You should never stop this medicine without consulting your doctor. Abrupt discontinuation can cause withdrawal symptoms and relapse of depression. - Myth: This medicine will make me gain weight immediately.
Fact: Weight gain is a possible side effect but not everyone experiences it. It can be managed with diet and exercise.
🔄 Alternative Options
Generic Alternatives
- Flupenthixol + Escitalopram (generic)
Brand Alternatives
- Anxifree Tablet