askafex tr suspension - Terbutaline (2.5mg/5ml) + Bromhexine (8mg/5ml) medicine

Askafex TR Suspension: Complete Medicine Guide

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🏭 Asklepios Remedies Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 23, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
12 min read
Evidence: Moderate for symptomatic relief in respiratory conditions with mucus.
Reviewed by
SaathiMed Expert Panel | Oct 23, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Rapid, irregular, or pounding heartbeat
  • Chest pain or tightness
  • Severe allergic reaction (rash, itching, swelling of face, lips, tongue, or throat, difficulty breathing)
  • Worsening of breathing or bronchospasm
  • Severe dizziness or fainting
  • Muscle weakness or cramps (possible low potassium)
  • Yellowing of skin or eyes (jaundice)

If experiencing severe symptoms, call emergency services immediately.

What is askafex tr suspension used for?

This medicine is a combination of terbutaline (a bronchodilator) and bromhexine (a mucolytic) used to relieve cough with thick mucus in conditions like bronchitis and asthma. It works by relaxing airways and thinning mucus, making it easier to cough up.

  • Generic Name: Terbutaline + Bromhexine
  • Manufacturer: Asklepios Remedies Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 askafex tr suspension के बारे में (Hindi Summary)

उपयोग: यह दवा टर्ब्यूटलाइन और ब्रोमहेक्सिन का संयोजन है, जिसका उपयोग खांसी के इलाज में किया जाता है जिसमें गाढ़ा बलगम होता है। यह ब्रोंकाइटिस, अस्थमा और अन्य श्वसन संक्रमणों में राहत देती है। यह वायुमार्ग को फैलाकर और बलगम को पतला करके काम करती है।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में कंपन, घबराहट, सिरदर्द, मतली और उल्टी शामिल हैं। गंभीर दुष्प्रभावों में तेज़ धड़कन, छाती में दर्द, और एलर्जी की प्रतिक्रिया शामिल हो सकती है। यदि आपको कोई असामान्य लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। खुराक बढ़ाएं या घटाएं नहीं। उपयोग से पहले बोतल को अच्छी तरह हिलाएं। सही मापने वाले कप का उपयोग करें। यदि आपको चक्कर या कंपन महसूस हो तो वाहन न चलाएं। अपने डॉक्टर को अपनी सभी स्वास्थ्य समस्याओं के बारे में बताएं।

💡 Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

💊 askafex tr suspension Uses & Benefits

[{"condition":"Productive cough associated with bronchitis","description":"Helps to loosen mucus and relax airways, making it easier to cough up phlegm.","evidence":"Well-established"},{"condition":"Asthma with thick mucus","description":"Provides symptomatic relief by bronchodilation and mucolysis.","evidence":"Well-established"},{"condition":"Chronic obstructive pulmonary disease (COPD) with mucus hypersecretion","description":"May help in clearing secretions and improving breathing.","evidence":"Limited"}]

Off-label uses: []

Primary treatment for: Productive cough associated with respiratory tract infections

Also treats: Asthma, Bronchitis, COPD

📋 Drug Information

Generic Name(s)Terbutaline + Bromhexine
Brand NameAskafex TR Suspension
ManufacturerAsklepios Remedies Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassRESPIRATORY
Action ClassBronchodilator + Mucolytic
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a cool, dry place. Protect from direct sunlight. Do not freeze. Keep the bottle tightly closed.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Always shake the bottle well before measuring the dose to ensure uniform mixing of the suspension.
2
Use a calibrated measuring cup or oral syringe for accurate dosing; household spoons are not reliable.
3
Take this medicine with food if it causes stomach upset.
4
Avoid giving this medicine to children under 2 years without a doctor's advice.
5
Monitor for tremors or increased heart rate; report to your doctor if these occur.
6
Do not use this medicine for more than 7 days without consulting your doctor.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Productive cough with thick mucus
This medicine is commonly prescribed for this.
Likely Use
❌
Dry cough
This medicine is not typically used for dry cough.
Not Primary
❌
Fever
This medicine is not a primary fever reducer.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionTerbutaline is well absorbed from the gastrointestinal tract after oral administration. Bromhexine is also absorbed orally. However, specific bioavailability data for this combination suspension is not established from the available information.
DistributionTerbutaline distributes widely in the body, including the lungs. Bromhexine is distributed to various tissues, with high concentrations in the liver, kidneys, and lungs. Protein binding information for this combination is not established from the available information.
Protein BindingNot established from the available information.
MetabolismTerbutaline undergoes extensive first-pass metabolism in the liver, primarily by conjugation with sulfate. Bromhexine is metabolized in the liver to active metabolites, including ambroxol. Specific details for this combination are not established from the available information.
Half-LifeThe elimination half-life of terbutaline is approximately 3 to 4 hours. The elimination half-life of bromhexine is not well established but is thought to be around 1 to 2 hours. Specific data for this combination is not established from the available information.
ExcretionTerbutaline and its metabolites are primarily excreted in the urine. Bromhexine metabolites are excreted mainly in the urine. Specific details for this combination are not established from the available information.
BioavailabilityThe oral bioavailability of terbutaline is approximately 10-15% due to first-pass metabolism. The bioavailability of bromhexine is not well established. Specific data for this combination is not established from the available information.
Onset of ActionThe onset of bronchodilation after oral terbutaline is typically within 30 minutes to 1 hour. The mucolytic effect of bromhexine may take longer, usually within 2-3 days of regular use.
Peak Plasma TimePeak plasma concentration of terbutaline after oral administration is about 2-4 hours. Peak plasma time for bromhexine is not established from the available information.
Duration of ActionThe bronchodilator effect of terbutaline lasts about 4-6 hours. The mucolytic effect of bromhexine lasts as long as the medicine is taken regularly.

How It Works

This medicine combines two active ingredients with complementary actions. Terbutaline is a selective beta-2 adrenergic agonist that binds to beta-2 receptors in the airways, leading to relaxation of bronchial smooth muscle and bronchodilation. Bromhexine is a mucolytic agent that reduces the viscosity of mucus by breaking down acidic mucopolysaccharide fibers, thereby facilitating its removal from the respiratory tract.

Mechanism Steps

1
Terbutaline binds to beta-2 receptors: Terbutaline selectively binds to beta-2 adrenergic receptors on bronchial smooth muscle cells.
2
Activation of intracellular signaling: This binding activates adenylate cyclase, increasing cyclic AMP levels, which leads to relaxation of the smooth muscle.
3
Bronchodilation: The relaxation of bronchial smooth muscle results in widening of the airways, easing breathing.
4
Bromhexine reduces mucus viscosity: Bromhexine breaks down the structure of acidic mucopolysaccharides in mucus, making it thinner and easier to expel.
5
Enhanced mucociliary clearance: The thinned mucus is more easily moved by cilia and coughed out, helping to clear the airways.

💡 How to Take askafex tr suspension

Strength: Each 5 ml of suspension contains Terbutaline 2.5 mg and Bromhexine 8 mg.

1Shake the bottle well before each use.
2Use the measuring cup or syringe provided to measure the correct dose.
3Take the medicine orally, with or without food.
4If it upsets your stomach, take it with a meal or snack.
5After taking, rinse the measuring device with water.
6Close the bottle tightly and store as directed.

Dosage Information

Adult DosageThe usual adult dose of this medicine is 5-10 ml (containing terbutaline 2.5-5 mg and bromhexine 8-16 mg) taken three times a day, or as directed by your physician. The dose may be adjusted based on the severity of the condition and the patient's response. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may be more sensitive to the effects of terbutaline, especially cardiovascular effects. Use with caution and start with a lower dose. Dose must be individualized by a qualified clinician.
Renal ImpairmentUse with caution in patients with renal impairment. Dose adjustment may be necessary. Consult your doctor.
Hepatic ImpairmentUse with caution in patients with hepatic impairment. Dose adjustment may be necessary. Consult your doctor.
Maximum Daily DoseThe maximum recommended daily dose is 30 ml (terbutaline 15 mg and bromhexine 48 mg) in divided doses. Do not exceed this dose without medical advice.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset.
Caffeine
Limit
May increase nervousness and tremors.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of askafex tr suspension

✅ Common Side Effects

Tremors (Common (5-10%))
Usually resolves with continued use. If bothersome, consult your doctor.
Nervousness (Common (5-10%))
Try to relax and avoid caffeine. Consult doctor if persistent.
Headache (Common (5-10%))
Rest and stay hydrated. Consult doctor if severe.
Nausea (Common (5-10%))
Take with food to reduce nausea. Consult doctor if persistent.
Vomiting (Common (5-10%))
Take with food and stay hydrated. Consult doctor if severe.

🚨 Serious Side Effects

Rapid or irregular heartbeat (Uncommon (0.1-1%))
Seek immediate medical attention if you experience palpitations or chest discomfort.
Severe allergic reaction (Rare (<0.1%))
Seek emergency help if you notice rash, itching, swelling of face, lips, or throat, or difficulty breathing.
Low potassium levels (Rare (<0.1%))
Report muscle weakness or cramps to your doctor.

⚠️ Rare Side Effects

Paradoxical bronchospasm
Seek immediate medical attention if breathing worsens after taking this medicine.
Severe skin reactions
Discontinue and seek medical help if you develop a severe rash or blistering.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Propranolol Major
MAOIs Major
Tricyclic antidepressants Major
Furosemide Moderate
Corticosteroids Moderate
Theophylline Moderate
Erythromycin Minor

🚨 Major Interactions

  • Beta-blockers (e.g., propranolol)
  • Monoamine oxidase inhibitors (MAOIs)
  • Tricyclic antidepressants

⚡ Moderate Interactions

  • Diuretics (e.g., furosemide)
  • Corticosteroids
  • Xanthine derivatives (e.g., theophylline)

🍷 Alcohol Interaction

Alcohol may increase the risk of dizziness, drowsiness, and cardiovascular side effects. It is advisable to avoid alcohol while taking this medicine.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Hypersensitivity to terbutaline, bromhexine, or any component of the formulation","Severe cardiovascular disease (e.g., severe hypertension, arrhythmias)","Hyperthyroidism","Diabetes mellitus (uncontrolled)","Severe hepatic or renal impairment"]

⚠️ Warnings & Precautions

["Use with caution in patients with cardiovascular disorders, including coronary insufficiency, arrhythmias, and hypertension.","May cause tremors and nervousness; avoid driving or operating machinery if affected.","Use with caution in patients with diabetes, as terbutaline may increase blood glucose levels.","Use with caution in patients with hyperthyroidism.","Not recommended for children under 2 years of age unless prescribed by a doctor.","Do not exceed the recommended dose; excessive use may lead to cardiac side effects."]

🤱 Lactation Safety

Terbutaline is excreted in breast milk and may cause adverse effects in the nursing infant. Bromhexine is also likely excreted in breast milk. Consult your doctor before breastfeeding while taking this medicine.

💊 Overdose Management

Overdose may cause severe tachycardia, palpitations, tremors, nausea, and vomiting. Seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not increase or decrease the dose without consulting your healthcare provider. Shake the bottle well before each use to ensure the medicine is evenly mixed. Use a proper measuring device to measure the dose accurately. Avoid driving or operating heavy machinery if you feel dizzy or shaky after taking this medicine. Inform your doctor if you have a history of heart disease, high blood pressure, diabetes, or thyroid problems. Do not take this medicine for a longer period than recommended unless advised by your doctor. Keep out of reach of children. Store in a cool, dry place away from direct sunlight. Do not use after the expiry date.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are more prone to cardiovascular side effects such as tachycardia and arrhythmias. Use with caution and monitor closely. Dose adjustment may be necessary.

🤰 Pregnancy Planning (TTC)

If you are planning to become pregnant, consult your doctor before taking this medicine. Terbutaline is FDA pregnancy category C; bromhexine is not classified. Use only if clearly needed.

🏥 Post-Surgery Considerations

Inform your surgeon and anesthesiologist if you are taking this medicine before surgery. It may interact with anesthetic agents and affect heart rate and blood pressure.

🦷 Dental Procedures

Inform your dentist if you are taking this medicine, as it may cause dry mouth or interact with medications used during dental procedures.

💚 Lifestyle Tips for Better Results

🏃
Stay well hydrated to help thin mucus.
🥗
Use a humidifier to add moisture to the air.
😴
Avoid smoking and exposure to secondhand smoke.
💧
Practice deep breathing exercises to improve lung function.
🧘
Get plenty of rest to support recovery.

🏋️ Exercise Considerations

Avoid strenuous exercise if you experience tremors, dizziness, or rapid heartbeat after taking this medicine. Light activity like walking is generally safe, but consult your doctor before starting any exercise regimen.

🥗 Diet Recommendations

Include warm fluids like soups and herbal teas.
Avoid cold and sugary drinks that can thicken mucus.
Eat a balanced diet rich in fruits and vegetables.
Limit caffeine intake as it may worsen tremors.

💼 Impact on Daily Work & Life

This medicine may cause dizziness or tremors, which can affect your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. It is generally safe to continue desk work.

🛑 When to Stop This Medicine

Stop taking this medicine and consult your doctor if your symptoms do not improve within 7 days, if they worsen, or if you experience any serious side effects. Do not stop abruptly if you have been taking it for a long time without medical advice.

📅 Long-Term Use Effects

Long-term use of this medicine should be under medical supervision. Prolonged use of terbutaline may lead to tolerance and reduced effectiveness. Regular monitoring of heart rate, blood pressure, and potassium levels may be required. Do not use for extended periods without consulting your doctor.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Steam inhalation

Helps to loosen mucus and ease breathing.

Evidence: Well-established
Chest physiotherapy

Techniques to help clear mucus from the airways.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

There are no known interactions between this medicine and vaccines. However, if you are due for a vaccination, inform your healthcare provider that you are taking this medicine.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

When traveling, carry this medicine in its original packaging with the prescription label intact. Bring a copy of your prescription in case you need to show it at customs. Store it in a cool, dry place, away from direct sunlight. If traveling across time zones, adjust dosing times gradually to maintain consistent intervals. Keep it in your carry-on luggage to avoid temperature extremes in checked baggage.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 35-year-old man with acute bronchitis
He was prescribed this medicine for a productive cough with thick mucus. After taking it as directed for 5 days, he noticed significant relief in chest congestion and was able to cough up mucus more easily. He experienced mild tremors initially, which subsided after a few days.
💡 Lesson: This medicine can effectively relieve cough with mucus, but mild side effects like tremors may occur initially and usually resolve.
👤 A 60-year-old woman with COPD exacerbation
She was given this medicine along with other treatments. She reported improved breathing and easier expectoration. However, she experienced palpitations, which were managed by reducing the dose under medical supervision.
💡 Lesson: Elderly patients may be more sensitive to cardiovascular side effects; dose adjustment may be needed.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: The bronchodilator effect starts within 30-60 minutes, but the mucolytic effect may take 2-3 days of regular use.

Q: Can I take it on an empty stomach?

A: It can be taken with or without food, but taking it with food reduces the risk of stomach upset.

Q: Is it safe for children?

A: It should only be used in children under medical supervision. Pediatric dosing is not established from available information.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my heart?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for askafex tr suspension

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can cure asthma permanently.
    Fact: This medicine provides symptomatic relief but does not cure asthma. Asthma management requires a comprehensive plan.
  • Myth: It is safe to take this medicine without a prescription.
    Fact: This is a prescription medicine and should only be taken under medical supervision.

📊 Comparison with Similar Medicines

[{"medicine":"This medicine","composition":"Terbutaline 2.5mg/5ml + Bromhexine 8mg/5ml","onset":"30-60 minutes","duration":"4-6 hours"},{"medicine":"Terbutaline + Ambroxol","composition":"Terbutaline 2.5mg/5ml + Ambroxol 15mg/5ml","onset":"30-60 minutes","duration":"4-6 hours"}]

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