ascoxol syrup - Terbutaline (12.5mg/5ml) + Bromhexine (2mg/5ml) medicine

Ascoxol Syrup: Complete Guide To Uses, Side Effects, And Safety

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🏭 Unigroups Pharma 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 27, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Moderate for symptom relief in respiratory conditions.
Reviewed by
SaathiMed Expert Panel | Oct 27, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Difficulty breathing or worsening of asthma symptoms
  • Chest pain or palpitations
  • Severe allergic reaction (rash, swelling of face/lips/throat)
  • Irregular heartbeat or fainting
  • Severe headache with visual changes
  • Muscle weakness or cramps (possible hypokalemia)
  • High blood sugar levels in diabetic patients

If experiencing severe symptoms, call emergency services immediately.

What is ascoxol syrup used for?

This medicine is a combination of terbutaline and bromhexine used to treat respiratory conditions like bronchitis and asthma. Terbutaline opens the airways, while bromhexine thins mucus, making it easier to breathe and cough. It is available as a syrup and should be taken as prescribed by a doctor.

  • Generic Name: Terbutaline (12.5mg/5ml) + Bromhexine (2mg/5ml)
  • Manufacturer: Unigroups Pharma
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 ascoxol syrup के बारे में (Hindi Summary)

उपयोग: यह दवा टर्ब्यूटलाइन और ब्रोमहेक्सिन का संयोजन है, जिसका उपयोग ब्रोंकाइटिस, अस्थमा और अन्य श्वसन संबंधी समस्याओं में किया जाता है। यह श्वसन मार्ग की मांसपेशियों को आराम देकर सांस लेने में मदद करती है और बलगम को पतला करके खांसी को आसान बनाती है। यह दवा केवल डॉक्टर के पर्चे पर ही लेनी चाहिए।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में हाथ-पैरों में कंपन, घबराहट, सिरदर्द और धड़कन तेज होना शामिल हैं। ये आमतौर पर हल्के होते हैं और कुछ समय में ठीक हो जाते हैं। कभी-कभी मतली या पेट में परेशानी हो सकती है। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन यदि सांस लेने में कठिनाई, सीने में दर्द, या चेहरे पर सूजन हो तो तुरंत डॉक्टर से मिलें।

सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। दवा की मात्रा खुद से न बढ़ाएं या घटाएं। यदि आपको हृदय रोग, उच्च रक्तचाप, मधुमेह या थायरॉइड की समस्या है तो डॉक्टर को बताएं। दवा लेने के बाद चक्कर आ सकते हैं, इसलिए वाहन चलाने या मशीन चलाने से बचें। गर्भवती या स्तनपान कराने वाली महिलाएं डॉक्टर से सलाह लें। बच्चों की पहुंच से दूर रखें।

💡 Did You Know? The Indian pharmaceutical market is expected to reach $130 billion by 2030.

💊 ascoxol syrup Uses & Benefits

[{"condition":"Bronchitis","description":"Helps relieve bronchospasm and loosen mucus, making breathing easier and cough more productive.","evidence":"Well-established"},{"condition":"Asthma","description":"Used as an adjunct to relieve acute bronchospasm and mucus plugging in some patients.","evidence":"Established for symptom relief, not for long-term control"},{"condition":"Chronic obstructive pulmonary disease (COPD)","description":"May help in managing symptoms of mucus hypersecretion and bronchospasm in some patients.","evidence":"Limited, used with caution"}]

Off-label uses: []

Primary treatment for: Bronchitis

Also treats: Asthma, COPD

📋 Drug Information

Generic Name(s)Terbutaline (12.5mg/5ml) + Bromhexine (2mg/5ml)
Brand Nameascoxol syrup
ManufacturerUnigroups Pharma
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassRESPIRATORY
Action Class
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a dry place, away from direct sunlight. Keep the bottle tightly closed. Do not freeze.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Always shake the bottle well before measuring the dose.
2
Use a proper measuring cup or spoon; household spoons are not accurate.
3
Take this medicine with food if it causes stomach upset.
4
Do not take this medicine for more than 7 days without consulting your doctor.
5
Inform your doctor if you have heart disease, high blood pressure, or diabetes before starting this medicine.
6
Avoid driving or operating machinery until you know how this medicine affects you.
7
Do not take this medicine with other cough and cold medicines without medical advice.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Cough with thick mucus
This medicine is commonly prescribed for this.
Likely Use
✅
Wheezing
This medicine helps relieve bronchospasm.
Likely Use
❌
Fever
This medicine is not a primary fever reducer.
Not Primary
❌
Sore throat
This medicine is not primarily used for sore throat.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionTerbutaline is well absorbed from the gastrointestinal tract after oral administration. Bromhexine is also absorbed orally. However, oral bioavailability of terbutaline is reduced due to first-pass metabolism.
DistributionTerbutaline distributes widely into body tissues, including the lungs. Bromhexine and its metabolites are distributed to various tissues, with high concentrations in the lungs, liver, and kidneys.
Protein BindingTerbutaline is approximately 25% bound to plasma proteins. Bromhexine is extensively bound to plasma proteins (approximately 95%).
MetabolismTerbutaline undergoes extensive first-pass metabolism in the liver, primarily by conjugation to sulfate and glucuronide. Bromhexine is metabolized in the liver to several metabolites, including ambroxol.
Half-LifeThe elimination half-life of terbutaline is approximately 3 to 4 hours. The elimination half-life of bromhexine is approximately 1 hour, but its active metabolite ambroxol has a longer half-life of about 10 hours.
ExcretionTerbutaline and its metabolites are excreted primarily in the urine. Bromhexine metabolites are excreted mainly in the urine and to a lesser extent in feces.
BioavailabilityOral bioavailability of terbutaline is approximately 10-15% due to first-pass metabolism. Bioavailability of bromhexine is approximately 70-80%.
Onset of ActionBronchodilation from terbutaline occurs within 30 minutes after oral administration. Mucolytic effect of bromhexine may take a few days to become noticeable.
Peak Plasma TimePeak plasma concentration of terbutaline is reached in about 2 to 4 hours after oral administration. Bromhexine peak levels are reached in about 1 hour.
Duration of ActionBronchodilation from terbutaline lasts about 4 to 6 hours. The mucolytic effect of bromhexine lasts for several hours.

How It Works

Terbutaline acts by selectively stimulating beta-2 adrenergic receptors in the bronchial smooth muscle, leading to relaxation and bronchodilation. Bromhexine works by increasing the production of serous fluid in the respiratory tract and breaking down the structure of mucus, reducing its viscosity and making it easier to expel.

Mechanism Steps

1
Beta-2 receptor stimulation: Terbutaline binds to beta-2 adrenergic receptors on bronchial smooth muscle cells, activating adenylate cyclase and increasing cyclic AMP levels.
2
Bronchial smooth muscle relaxation: Increased cyclic AMP leads to relaxation of bronchial smooth muscle, resulting in bronchodilation and easier breathing.
3
Mucolytic action of bromhexine: Bromhexine increases serous bronchial secretion and breaks down acidic mucopolysaccharide fibers in mucus, reducing its viscosity.
4
Enhanced mucociliary clearance: Thinner mucus is more easily moved by cilia and coughed out, helping clear airways.

💡 How to Take ascoxol syrup

Strength: Each 5 ml contains Terbutaline 12.5 mg and Bromhexine 2 mg.

1Shake the bottle well before each use.
2Use a measuring cup or spoon provided with the medicine to measure the correct dose.
3Take the medicine orally, with or without food, as directed by your doctor.
4If it upsets your stomach, take it with a meal or snack.
5Do not take more than the prescribed dose.
6After taking, close the bottle tightly and store as directed.

Dosage Information

Adult DosageThe usual adult dose of this medicine is 5-10 ml (one to two teaspoons) taken two to three times a day, or as directed by your doctor. The dose may vary depending on the condition being treated and the patient's response. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not self-adjust the dose.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician for appropriate dosing in children.
Elderly DosageElderly patients may be more sensitive to the effects of this medicine, especially cardiac effects. Use with caution and lower doses may be considered. Dose must be individualized by a qualified clinician.
Renal ImpairmentUse with caution in patients with renal impairment. Dose adjustment may be necessary. Consult your doctor.
Hepatic ImpairmentUse with caution in patients with hepatic impairment. Dose adjustment may be necessary. Consult your doctor.
Maximum Daily DoseThe maximum recommended daily dose is 30 ml (6 teaspoons) in divided doses, but this may vary. Do not exceed the dose prescribed by your doctor.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset.
Alcohol
Avoid
May increase dizziness and drowsiness.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of ascoxol syrup

✅ Common Side Effects

Tremors (Common (5-10%))
Usually resolves with continued use. If bothersome, consult your doctor.
Nervousness (Common (5-10%))
Try relaxation techniques. If persistent, consult your doctor.
Headache (Common (5-10%))
Rest and stay hydrated. Consult doctor if severe or persistent.
Palpitations (Uncommon (1-5%))
Report to your doctor if you feel your heart racing or pounding.
Nausea (Uncommon (1-5%))
Take with food to reduce stomach upset. Consult doctor if persistent.

🚨 Serious Side Effects

Severe allergic reaction (anaphylaxis) (Rare (<0.1%))
Seek immediate medical attention if you experience rash, itching, swelling of face/lips/throat, or difficulty breathing.
Irregular heartbeat (arrhythmia) (Rare (<0.1%))
Seek immediate medical attention if you feel dizzy, faint, or have chest pain.
Paradoxical bronchospasm (Rare (<0.1%))
If breathing becomes worse after taking this medicine, stop and seek immediate medical help.

⚠️ Rare Side Effects

Hypokalemia
Report muscle weakness or cramps to your doctor.
Hyperglycemia
Monitor blood sugar if diabetic. Consult doctor if levels rise.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Propranolol Major
MAOIs Major
Tricyclic antidepressants Major
Furosemide Moderate
Corticosteroids Moderate
Digoxin Moderate
Anticholinergics Minor

🚨 Major Interactions

  • Non-selective beta-blockers (e.g., propranolol)
  • Monoamine oxidase inhibitors (MAOIs)
  • Tricyclic antidepressants

⚡ Moderate Interactions

  • Diuretics (e.g., furosemide)
  • Corticosteroids
  • Digoxin

🍷 Alcohol Interaction

Alcohol may increase the central nervous system side effects of this medicine, such as dizziness and drowsiness. It is advisable to avoid alcohol while taking this medicine.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Hypersensitivity to terbutaline, bromhexine, or any component of the formulation","Severe cardiac disease, especially arrhythmias","Uncontrolled hypertension","Hyperthyroidism","Diabetes mellitus (relative contraindication; use with caution)","Severe hepatic or renal impairment (relative)"]

⚠️ Warnings & Precautions

["Use with caution in patients with cardiovascular disorders, including coronary insufficiency, arrhythmias, and hypertension.","May cause tremors and nervousness; avoid driving or operating machinery until effects are known.","May cause hypokalemia; monitor potassium levels, especially with concomitant diuretics or corticosteroids.","May increase blood glucose levels; monitor in diabetic patients.","Not recommended for use in children under 12 years without medical advice.","Do not exceed the recommended dose; excessive use may lead to cardiac side effects.","Consult a doctor if symptoms persist or worsen after 7 days of use."]

🤱 Lactation Safety

Terbutaline is excreted in breast milk in small amounts. Bromhexine is also excreted in breast milk. Consult your doctor before using this medicine while breastfeeding.

💊 Overdose Management

Overdose may cause severe tachycardia, palpitations, tremors, nausea, vomiting, and hypotension. Seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote. Gastric lavage may be considered if ingestion is recent. Monitor cardiac function and electrolytes.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not increase or decrease the dose without consulting your doctor. Inform your doctor if you have heart disease, high blood pressure, diabetes, or thyroid problems before taking this medicine. Avoid driving or operating heavy machinery until you know how this medicine affects you, as it may cause dizziness or tremors. Do not take this medicine with other cough and cold medicines without checking with your doctor or pharmacist. If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before using this medicine. Keep this medicine out of reach of children.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients may be more sensitive to the cardiac and central nervous system effects of this medicine. Use with caution and lower doses may be considered. Regular monitoring of heart rate and blood pressure is advised.

🤰 Pregnancy Planning (TTC)

If you are planning to become pregnant, consult your doctor before taking this medicine. It should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

🏥 Post-Surgery Considerations

Consult your doctor before using this medicine after surgery, especially if you have heart or lung conditions. It may interact with other medications used during surgery.

🦷 Dental Procedures

Inform your dentist if you are taking this medicine, as it may cause dry mouth or interact with other medications used during dental procedures.

💚 Lifestyle Tips for Better Results

🏃
Avoid smoking and exposure to secondhand smoke.
🥗
Use a humidifier to keep the air moist, which can help loosen mucus.
😴
Stay well hydrated by drinking plenty of fluids.
💧
Practice deep breathing exercises to improve lung function.
🧘
Get adequate rest to help your body recover.
🌞
Avoid allergens and pollutants that can trigger respiratory symptoms.

🏋️ Exercise Considerations

Avoid strenuous exercise while taking this medicine, especially if you experience tremors, palpitations, or dizziness. Light activity like walking may be beneficial, but consult your doctor before starting any exercise routine.

🥗 Diet Recommendations

Drink warm fluids like herbal tea or soup to help soothe the throat and loosen mucus.
Include foods rich in vitamin C and antioxidants to support immune health.
Avoid cold drinks and ice cream, which may worsen cough.
Reduce intake of processed foods and sugary drinks.
Eat a balanced diet with plenty of fruits and vegetables.

💼 Impact on Daily Work & Life

This medicine may cause dizziness, tremors, or drowsiness, which can affect your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. It is advisable to inform your employer if your job involves operating heavy machinery.

🛑 When to Stop This Medicine

Stop taking this medicine and consult your doctor if your symptoms do not improve within 7 days, if they worsen, or if you experience any serious side effects. Do not stop abruptly if you have been taking it for a long time without medical advice.

📅 Long-Term Use Effects

Long-term use of this medicine should be under medical supervision. Prolonged use of terbutaline may lead to tolerance and reduced effectiveness. Regular monitoring of heart rate, blood pressure, and potassium levels may be required. Do not use for longer than prescribed without consulting your doctor.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Steam inhalation

Helps loosen mucus and ease breathing.

Evidence: Well-established for symptom relief
Chest physiotherapy

Techniques to help clear mucus from the airways.

Evidence: Established
Inhaled bronchodilators

May be preferred for targeted relief with fewer systemic side effects.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

There are no known interactions between this medicine and vaccines. However, if you are scheduled for vaccination, inform your healthcare provider about all medicines you are taking.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

When traveling, carry this medicine in its original packaging with the prescription label intact. Bring a copy of your prescription in case you need to show it at customs or to a healthcare provider. Store it at room temperature and protect it from extreme heat or direct sunlight. If you are crossing time zones, adjust your dosing schedule gradually, but consult your doctor for specific advice. Always pack enough medicine for your entire trip plus extra in case of delays.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 35-year-old man with acute bronchitis
He was prescribed this medicine for a week. He noticed significant relief in cough and breathing within 3 days. He experienced mild tremors initially, which subsided after a few days. He was advised to take it with food to avoid stomach upset.
💡 Lesson: Taking the medicine with food and completing the prescribed course helps achieve optimal results with minimal side effects.
👤 A 50-year-old woman with asthma exacerbation
She used this medicine as an add-on to her inhaler during an asthma flare-up. It helped loosen mucus and eased her breathing. She was monitored for heart rate and potassium levels due to her history of hypertension.
💡 Lesson: This medicine can be helpful for symptom relief in asthma but should be used under medical supervision, especially if you have other health conditions.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: Terbutaline starts working within 30 minutes to relax the airways, while bromhexine may take a few days to show its full mucolytic effect.

Q: Can I take this medicine with food?

A: Yes, you can take it with or without food. If it upsets your stomach, take it with a meal or snack.

Q: Is it safe to take during pregnancy?

A: Consult your doctor before taking this medicine during pregnancy. It should be used only if clearly needed.

Q: What should I do if I miss a dose?

A: If you miss a dose, take it as soon as you remember. If it's almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my heart?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🛑 Myths vs. Facts

  • Myth: This medicine can cure asthma permanently.
    Fact: This medicine only provides symptomatic relief and does not cure asthma. Asthma management requires a comprehensive plan.
  • Myth: It is safe to take this medicine without a prescription.
    Fact: This is a prescription medicine and should only be taken under a doctor's supervision.
  • Myth: More medicine means faster relief.
    Fact: Taking more than the prescribed dose can lead to serious side effects. Always follow your doctor's instructions.

📊 Comparison with Similar Medicines

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