Arkox MR 60mg/4mg Tablet - Uses, Price, Side Effects
What is arkox mr 60mg/4mg tablet used for?
Arkox MR 60mg/4mg Tablet is a combination of Etoricoxib (a COX-2 inhibitor) and Thiocolchicoside (a muscle relaxant). It is used to relieve pain and muscle spasms associated with musculoskeletal conditions such as back pain, neck pain, and joint pain. Etoricoxib reduces inflammation and pain, while Thiocolchicoside relaxes muscles, providing effective relief.
- Generic Name: Etoricoxib + Thiocolchicoside
- Manufacturer: Raddison Health Care Pvt Ltd
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ arkox mr 60mg/4mg tablet Uses & Benefits
Acute musculoskeletal pain, osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, muscle spasms.
Off-label uses: Chronic low back pain, fibromyalgia (limited evidence).
๐ Drug Information
| Generic Name(s) | Etoricoxib + Thiocolchicoside |
| Brand Name | Alock E TH 60mg/4mg Tablet |
| Manufacturer | Raddison Health Care Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | NSAID + Muscle Relaxant |
| Route of Administration | Oral |
| Storage | Store at room temperature (20-25ยฐC), protect from moisture and light. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Etoricoxib selectively inhibits COX-2, reducing prostaglandin synthesis; Thiocolchicoside acts as a GABA-A receptor agonist and glycine receptor agonist, producing muscle relaxation.
Mechanism Steps
๐ก How to Take arkox mr 60mg/4mg tablet
Follow your doctor's prescription exactly.
Dosage Timeline
โ ๏ธ Side Effects of arkox mr 60mg/4mg tablet
โ Common Side Effects
- Nausea
- Dyspepsia
- Diarrhea
- Headache
- Dizziness
- Somnolence
๐จ Serious Side Effects
- GI bleeding
- Cardiovascular events (MI, stroke)
- Hepatotoxicity
- Renal failure
- Anaphylaxis
โ ๏ธ Rare Side Effects
- Stevens-Johnson syndrome
- Toxic epidermal necrolysis
- Aplastic anemia
- Seizures
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | Increased bleeding risk |
| Lithium | Moderate | Increased lithium toxicity |
| Methotrexate | Moderate | Increased methotrexate toxicity |
| ACE Inhibitors | Minor | Reduced antihypertensive effect |
| Diuretics | Minor | Reduced diuretic effect |
๐จ Major Interactions
- Warfarin
- Methotrexate
- Lithium
- ACE inhibitors
- Diuretics
- Aspirin
โก Moderate Interactions
- CYP3A4 inhibitors (e.g., ketoconazole)
- CYP3A4 inducers (e.g., rifampin)
- Anticoagulants
- Antiplatelets
โน๏ธ Minor Interactions
- Antacids
- Corticosteroids
๐ฝ๏ธ Food Interactions
Food may delay absorption of etoricoxib but does not affect extent; thiocolchicoside absorption unaffected.
๐ท Alcohol Interaction
Increased risk of gastrointestinal bleeding and hepatotoxicity.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity, pregnancy, breastfeeding, severe hepatic/renal impairment, active peptic ulcer, history of asthma, CV disease (etoricoxib), myasthenia gravis (thiocolchicoside).
๐ Monitoring Parameters
Liver function, renal function, blood pressure, signs of GI bleeding, cardiovascular status.
๐คฑ Lactation Safety
Not recommended; both drugs excreted in breast milk.
๐ Overdose Management
Symptomatic and supportive; no specific antidote. Induce emesis or gastric lavage if recent.
โฐ Missed Dose
Take as soon as remembered; skip if almost time for next dose. Do not double dose.
๐จโโ๏ธ Reviewed by Expert
โญ User Reviews
Effective and reliable. Worked as expected.
Helpful and effective medicine as per my experience. Always consult a doctor.
Helpful and effective medicine as per my experience. Always consult a doctor.
Good quality medicine. Satisfied with the outcome.
This medicine was effective for me. I followed the doctor's advice.