Arbaz 60mg Injection - Uses, Price, Side Effects
What is arbaz 60mg injection used for?
Arbaz 60mg Injection contains Cabazitaxel, a taxane chemotherapy drug used to treat metastatic castration-resistant prostate cancer after prior docetaxel therapy. It works by inhibiting microtubule depolymerization, disrupting cancer cell division. Administered intravenously under medical supervision.
- Generic Name: Cabazitaxel
- Manufacturer: Adley Formulations
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ arbaz 60mg injection Uses & Benefits
Metastatic castration-resistant prostate cancer (mCRPC) previously treated with docetaxel-containing regimen.
Off-label uses: Advanced breast cancer, Non-small cell lung cancer, Ovarian cancer
๐ Drug Information
| Generic Name(s) | Cabazitaxel |
| Brand Name | Arbaz 60mg Injection |
| Manufacturer | Adley Formulations |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | Alkaloids-cytotoxic agents |
| Route of Administration | Intravenous infusion over 1 hour. |
| Storage | Store at 25ยฐC (77ยฐF); excursions permitted to 15-30ยฐC; protect from light; do not refrigerate or freeze. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Cabazitaxel binds to tubulin, promoting microtubule assembly and stabilizing them, thereby inhibiting microtubule disassembly, leading to mitotic arrest and cell death.
Mechanism Steps
๐ก How to Take arbaz 60mg injection
Follow your doctor's prescription exactly.
Dosage Timeline
โ ๏ธ Side Effects of arbaz 60mg injection
โ Common Side Effects
- Neutropenia
- Anemia
- Thrombocytopenia
- Diarrhea
- Fatigue
- Nausea
- Vomiting
- Alopecia
๐จ Serious Side Effects
- Febrile neutropenia
- Severe hypersensitivity reactions
- Gastrointestinal hemorrhage
- Interstitial lung disease
- Renal failure
โ ๏ธ Rare Side Effects
- Cardiac arrhythmias
- Seizures
- Hemolytic uremic syndrome
- Stevens-Johnson syndrome
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | Increased bleeding risk |
| CYP3A4 Inhibitors (e.g., Ketoconazole) | Major | Increased cabazitaxel toxicity |
| CYP3A4 Inducers (e.g., Rifampin) | Moderate | Reduced cabazitaxel efficacy |
๐จ Major Interactions
- CYP3A4 inhibitors (e.g., ketoconazole, ritonavir)
- CYP3A4 inducers (e.g., rifampin, carbamazepine)
โก Moderate Interactions
- Warfarin
- Clopidogrel
- Statins (e.g., simvastatin)
โน๏ธ Minor Interactions
- Grapefruit juice
- St. John's Wort
๐ฝ๏ธ Food Interactions
No significant food interactions; avoid grapefruit juice due to CYP3A4 inhibition.
๐ท Alcohol Interaction
Avoid alcohol as it may increase hepatotoxicity risk.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to cabazitaxel or polysorbate 80; severe hepatic impairment (Child-Pugh C); neutropenia (ANC <1500/mm3); pregnancy.
๐ Monitoring Parameters
Complete blood count (CBC) with differential, liver function tests, renal function, and hypersensitivity reactions during infusion.
๐คฑ Lactation Safety
Not recommended; discontinue breastfeeding during treatment.
๐ Overdose Management
No specific antidote; manage with supportive care, including G-CSF for neutropenia and monitoring for hypersensitivity.
โฐ Missed Dose
Do not double dose; administer as soon as possible if within 12 hours; otherwise skip and resume next scheduled dose.
๐จโโ๏ธ Reviewed by Expert
๐ Substitutes for arbaz 60mg injection
View AllAlternative brands with exact same active ingredient (Cabazitaxel (60mg)):
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z-texel injectionBDR Pharmaceuticals Internationals Pvt โน12,689.97 73.6% CHEAPER
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cabapan injectionPanacea Biotec Ltd โน18,700.78 61% CHEAPER
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cabazirix 60mg injectionTherdose Pharma Pvt Ltd โน19,272.29 59.8% CHEAPER
-
cabocyta 60mg injectionAlkem Laboratories Ltd โน31,500.00 34.4% CHEAPER
-
jevatax 60mg injectionCipla Ltd โน36,000.00 25% CHEAPER
Medical Note: Always consult your doctor before switching medications.