aprofen syrup - Uses, Price, Side Effects & Substitutes
What is aprofen syrup used for?
Action or 1000mg Tablet (Paracetamol) is used to treat PAIN ANALGESICS. It contains Paracetamol (100mg), which Inhibits cyclooxygenase (COX) in the central nervous system, reducing prostaglan. Always consult your doctor before use. Take as prescribed.
- Generic Name: Paracetamol
- Manufacturer: Agrawal Pharmaceuticals
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ aprofen syrup Uses & Benefits
๐ Drug Information
| Generic Name(s) | Paracetamol |
| Brand Name | Action or 1000mg Tablet |
| Manufacturer | Agrawal Pharmaceuticals |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | Analgesic & Antipyretic-PCM |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30ยฐC); protect from light and moisture. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Inhibits cyclooxygenase (COX) in the central nervous system, reducing prostaglandin synthesis; also activates descending serotonergic pathways.
Mechanism Steps
๐ก How to Take aprofen syrup
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of aprofen syrup
โ Common Side Effects
- Nausea
- Vomiting
- Constipation
- Rash
๐จ Serious Side Effects
- Hepatotoxicity
- Acute liver failure
- Stevens-Johnson syndrome
- Toxic epidermal necrolysis
- Acute generalized exanthematous pustulosis
โ ๏ธ Rare Side Effects
- Thrombocytopenia
- Leukopenia
- Neutropenia
- Pancreatitis
- Hypersensitivity reactions
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | Increased INR and bleeding risk with high doses of paracetamol |
| Alcohol | Major | Increased hepatotoxicity risk |
| Isoniazid | Major | Increased hepatotoxicity risk |
| Rifampin | Major | Reduced paracetamol efficacy; increased hepatotoxicity |
| Carbamazepine | Major | Reduced paracetamol efficacy; increased hepatotoxicity |
| Phenytoin | Major | Reduced paracetamol efficacy; increased hepatotoxicity |
| Barbiturates | Major | Reduced paracetamol efficacy; increased hepatotoxicity |
| Cholestyramine | Moderate | Reduced absorption of paracetamol |
| Metoclopramide | Moderate | Increased absorption rate of paracetamol |
| Domperidone | Moderate | Increased absorption rate of paracetamol |
| Probenecid | Moderate | Reduced clearance of paracetamol |
| Oral contraceptives | Moderate | Reduced analgesic effect of paracetamol |
| Caffeine | Minor | Enhanced analgesic effect |
| Zidovudine | Minor | Increased risk of neutropenia |
| Lamotrigine | Minor | Reduced lamotrigine efficacy |
๐จ Major Interactions
- Warfarin
- Alcohol (chronic heavy use)
- Isoniazid
- Rifampin
- Carbamazepine
- Phenytoin
- Barbiturates
โก Moderate Interactions
- Cholestyramine
- Metoclopramide
- Domperidone
- Probenecid
- Oral contraceptives
โน๏ธ Minor Interactions
- Caffeine
- Zidovudine
- Lamotrigine
๐ฝ๏ธ Food Interactions
Food may delay absorption; high-fat meals reduce peak concentration.
๐ท Alcohol Interaction
Chronic heavy alcohol use increases hepatotoxicity risk; avoid concurrent use.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to paracetamol; severe hepatic impairment; chronic alcoholism.
๐ Monitoring Parameters
Liver function tests (in overdose or chronic high doses); renal function in long-term use.
๐คฑ Lactation Safety
Excreted in breast milk in small amounts; considered safe at therapeutic doses.
๐ Overdose Management
Activated charcoal if within 1 hour; N-acetylcysteine (NAC) as antidote; monitor liver function.
โฐ Missed Dose
Take as soon as remembered; if close to next dose, skip missed dose; do not double dose.
๐จโโ๏ธ Reviewed by Expert
๐ Substitutes for aprofen syrup
View AllAlternative brands with exact same active ingredient (Paracetamol (100mg)):
-
nicetamol 100 mg dropDr Reddy's Laboratories Ltd โน17.59 41.4% CHEAPER
-
Febnish Oral DropsRonish Bioceuticals โน18.50 38.3% CHEAPER
-
dolxor 100mg oral dropsTrireme Life Sciences Pvt Ltd โน19.00 36.7% CHEAPER
-
FEE Oral DropsSafetech Formulation โน20.00 33.3% CHEAPER
-
Fevalik 100mg SyrupSPS Medipol Pvt Ltd โน20.48 31.7% CHEAPER
-
molora 100mg oral dropsIva Healthcare Pvt. Ltd. โน22.97 23.4% CHEAPER
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Fevedot 100mg Oral DropsInvision Medi Sciences Pvt Ltd โน22.97 23.4% CHEAPER
-
novo oral dropsLichem Pharmaceuticals โน25.31 15.6% CHEAPER
-
neximol 100mg oral dropsNovo Medi Sciences Pvt Ltd โน25.51 15% CHEAPER
-
albimol 100mg oral dropsAlbia Biocare โน27.00 10% CHEAPER
Medical Note: Always consult your doctor before switching medications.