Apriace 10mg Tablet (Benazepril): Comprehensive Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Swelling of the face, lips, tongue, or throat, or difficulty breathing.
- Severe dizziness, fainting, or a sudden drop in blood pressure.
- Decreased urine output or swelling in the legs or ankles.
- Muscle weakness, irregular heartbeat, or palpitations.
- Yellowing of the skin or eyes, dark urine, or severe abdominal pain.
- Persistent dry cough that interferes with daily activities.
- Signs of infection such as fever, sore throat, or mouth ulcers.
- Severe abdominal pain that radiates to the back.
If experiencing severe symptoms, call emergency services immediately.
What is apriace 10mg tablet used for?
This medicine is an ACE inhibitor used to treat high blood pressure, heart failure, and to protect kidney function in diabetic patients. It works by relaxing blood vessels and reducing fluid retention. It is taken orally, usually once daily, and must be prescribed by a doctor.
- Generic Name: Benazepril (10mg)
- Manufacturer: Nectazen Pharmaceuticals
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 apriace 10mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा उच्च रक्तचाप (हाई ब्लड प्रेशर) के इलाज के लिए इस्तेमाल की जाती है। यह रक्त वाहिकाओं को आराम देकर और शरीर में पानी और नमक की मात्रा को कम करके रक्तचाप को कम करती है। इसके अलावा, यह दिल की विफलता (हार्ट फेल्योर) के इलाज में भी मदद करती है और मधुमेह (डायबिटीज) वाले रोगियों में गुर्दे की कार्यक्षमता की रक्षा करती है। यह दवा डॉक्टर के पर्चे के बिना नहीं लेनी चाहिए।
साइड इफेक्ट्स: इस दवा के आम दुष्प्रभावों में सूखी खांसी, चक्कर आना, सिरदर्द और थकान शामिल हैं। सूखी खांसी इस दवा के वर्ग की एक ज्ञात समस्या है। कुछ लोगों को पेट खराब या मतली भी हो सकती है। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन इनमें चेहरे, होंठ, जीभ या गले में सूजन (एंजियोएडेमा), गंभीर निम्न रक्तचाप, गुर्दे की समस्या और उच्च पोटेशियम स्तर शामिल हो सकते हैं। यदि आपको सांस लेने में कठिनाई, चेहरे पर सूजन, या बेहोशी महसूस हो, तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को लेने से पहले अपने डॉक्टर को अपनी सभी चिकित्सीय स्थितियों के बारे में बताएं, खासकर यदि आपको गुर्दे या यकृत की बीमारी, दिल की विफलता, या मधुमेह है। यदि आप गर्भवती हैं या गर्भवती होने की योजना बना रही हैं, तो इस दवा का उपयोग न करें क्योंकि यह भ्रूण के लिए हानिकारक हो सकती है। इस दवा को लेते समय शराब का सेवन सीमित करें क्योंकि इससे चक्कर आ सकते हैं। पोटेशियम सप्लीमेंट या नमक के विकल्प न लें जिनमें पोटेशियम हो, क्योंकि इससे पोटेशियम का स्तर खतरनाक रूप से बढ़ सकता है। अपने डॉक्टर से पूछे बिना कोई अन्य दवा शुरू या बंद न करें। नियमित रूप से रक्तचाप, गुर्दे की कार्यक्षमता और पोटेशियम के स्तर की जांच कराएं। इस दवा को अचानक बंद न करें।
💊 apriace 10mg tablet Uses & Benefits
- [{"condition":"Hypertension","description":"This medicine is used to lower high blood pressure in adults.
- It helps reduce the risk of strokes, heart attacks, and kidney problems.","evidence":"Well-established"},{"condition":"Heart failure","description":"This medicine is used to treat heart failure, often in combination with other medicines.
- It helps improve symptoms and reduce hospitalizations.","evidence":"Well-established"},{"condition":"Diabetic nephropathy","description":"This medicine is used to protect kidney function in people with diabetes and high blood pressure.
- It can slow the progression of kidney disease.","evidence":"Well-established"},{"condition":"Post-myocardial infarction","description":"This medicine may be used after a heart attack to improve survival and reduce the risk of future cardiovascular events.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Proteinuria in non-diabetic kidney disease","description":"Sometimes prescribed off-label to reduce protein in the urine in people with certain kidney diseases not caused by diabetes.","evidence":"Limited"},{"condition":"Scleroderma renal crisis","description":"May be used off-label in the management of scleroderma renal crisis, a rare kidney complication of scleroderma.","evidence":"Limited"}]
Primary treatment for: Hypertension
Also treats: Heart failure, Diabetic nephropathy, Post-myocardial infarction
📋 Drug Information
| Generic Name(s) | Benazepril (10mg) |
| Brand Name | apriace 10mg tablet |
| Manufacturer | Nectazen Pharmaceuticals |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | Angiotensin-converting enzyme (ACE) inhibitors |
| Route of Administration | Oral |
| Storage | Store at room temperature between 20°C and 25°C (68°F to 77°F). Keep the container tightly closed and protect from moisture and light. Do not store in the bathroom. Keep out of reach of children and pets. |
| Shelf Life | The shelf life of this medicine is typically 24 months from the date of manufacture. Check the expiration date on the packaging before use. Do not use if expired. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by inhibiting the angiotensin-converting enzyme (ACE). ACE is responsible for converting angiotensin I to angiotensin II, a potent vasoconstrictor. By blocking ACE, this medicine reduces the production of angiotensin II, leading to relaxation and widening of blood vessels (vasodilation). This lowers blood pressure and reduces the workload on the heart. Additionally, reduced angiotensin II levels decrease the secretion of aldosterone, a hormone that causes sodium and water retention. This leads to increased excretion of sodium and water, further lowering blood pressure. The medicine also increases levels of bradykinin, a substance that promotes vasodilation, which contributes to its blood pressure-lowering effect but may also cause side effects like dry cough.
Mechanism Steps
💡 How to Take apriace 10mg tablet
Strength: This medicine is available as an immediate-release oral tablet containing 10 mg of benazepril.
Dosage Information
| Adult Dosage | The usual starting dose of this medicine for hypertension is 10 mg taken orally once daily. The dose may be increased to 20 mg to 40 mg per day, either as a single dose or divided into two doses, based on blood pressure response. For heart failure, the starting dose is usually 5 mg once daily, which may be increased to 10 mg to 20 mg once daily as tolerated. In patients with renal impairment or those taking diuretics, a lower starting dose may be recommended. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and concomitant medications. Do not adjust your dose without consulting your doctor. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the blood pressure-lowering effects of this medicine. Start with a lower dose and monitor blood pressure and kidney function closely. Dose adjustments may be necessary based on renal function. |
| Renal Impairment | In patients with renal impairment, the dose of this medicine should be reduced. For patients with a creatinine clearance less than 30 mL/min, the recommended starting dose is 5 mg once daily. The dose may be titrated upward as needed, but close monitoring of renal function and potassium levels is required. |
| Hepatic Impairment | In patients with hepatic impairment, the metabolism of benazepril to benazeprilat may be reduced. However, no specific dose adjustment is recommended. Use with caution and monitor for adverse effects. |
| Maximum Daily Dose | The maximum recommended daily dose is 40 mg for hypertension and 20 mg for heart failure, but individual dosing must be determined by a qualified clinician. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of apriace 10mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Potassium supplements | Major | |
| Spironolactone | Major | |
| Losartan | Major | |
| Aliskiren | Major | |
| Ibuprofen | Major | |
| Naproxen | Major | |
| Furosemide | Moderate | |
| Hydrochlorothiazide | Moderate | |
| Lithium | Moderate | |
| Metformin | Moderate |
🚨 Major Interactions
- Potassium supplements
- Potassium-sparing diuretics (e.g., spironolactone)
- Angiotensin receptor blockers (ARBs)
- Aliskiren
- Nonsteroidal anti-inflammatory drugs (NSAIDs)
⚡ Moderate Interactions
- Diuretics
- Lithium
- Oral hypoglycemic agents
- Tricyclic antidepressants
- Antipsychotics
🍷 Alcohol Interaction
Alcohol may enhance the blood pressure-lowering effect of this medicine, leading to dizziness, lightheadedness, and increased risk of fainting. It is advisable to limit or avoid alcohol while taking this medicine, especially when starting treatment or adjusting the dose.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["History of angioedema related to previous ACE inhibitor therapy","Hereditary or idiopathic angioedema","Pregnancy (second and third trimesters)","Concomitant use with aliskiren in patients with diabetes","Hypersensitivity to benazepril or any other ACE inhibitor"]
⚠️ Warnings & Precautions
["Angioedema: Serious and potentially life-threatening swelling of the face, lips, tongue, throat, or intestines can occur. Seek immediate medical attention if suspected.","Hypotension: May occur, especially in volume-depleted or heart failure patients. Monitor blood pressure closely.","Renal impairment: Use with caution in patients with kidney disease. Dose adjustment may be needed.","Hyperkalemia: Risk increased with potassium supplements, potassium-sparing diuretics, or in renal impairment. Monitor potassium levels.","Cough: Persistent dry cough is common and may require discontinuation.","Neutropenia/Agranulocytosis: Rare but serious. Monitor white blood cell count in high-risk patients.","Fetal toxicity: Contraindicated in pregnancy. Can cause injury and death to the developing fetus.","Hepatic failure: Rare cases reported. Discontinue if jaundice or marked liver enzyme elevation occurs."]
🤱 Lactation Safety
Benazepril and its metabolites are excreted in small amounts in breast milk. Due to the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or discontinue the medicine, taking into account the importance of the medicine to the mother. Consult your doctor before breastfeeding.
💊 Overdose Management
Overdose of this medicine may cause severe hypotension, dizziness, and electrolyte imbalances. If you suspect an overdose, seek emergency medical attention immediately. Treatment is supportive and may include intravenous fluids, placement in a supine position, and administration of vasopressors if needed. Benazeprilat can be removed by hemodialysis.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Before you start taking this medicine, there are several important safety points to keep in mind. First, always tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding. This medicine is not safe during pregnancy, especially in the second and third trimesters, as it can harm the baby. If you become pregnant while taking this medicine, contact your doctor immediately. Second, inform your doctor about all your medical conditions, especially if you have kidney disease, liver disease, heart failure, diabetes, or a history of angioedema. Your doctor may need to adjust your dose or monitor you more closely. Third, this medicine can interact with other medicines. Do not start or stop any other medicine without consulting your doctor. This includes over-the-counter medicines, herbal supplements, and vitamins. Particularly, avoid potassium supplements and salt substitutes containing potassium unless your doctor tells you otherwise, as this medicine can increase potassium levels in your body. Fourth, this medicine may cause dizziness. Avoid driving or operating heavy machinery until you know how this medicine affects you. Alcohol can increase dizziness and low blood pressure, so it is best to limit or avoid alcohol. Fifth, keep all your doctor appointments and get regular blood tests to check your kidney function and potassium levels. Sixth, do not stop taking this medicine suddenly, as this can cause your blood pressure to rise dangerously. Always consult your doctor before stopping. Seventh, if you miss a dose, take it as soon as you remember, but if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose. Eighth, store this medicine at room temperature, away from moisture and heat. Keep it out of reach of children. Ninth, if you experience any signs of a severe allergic reaction, such as swelling of the face, lips, or throat, or difficulty breathing, seek emergency medical help immediately. Tenth, this medicine may not work for everyone, and your doctor may need to adjust the dose or add another medicine to control your blood pressure effectively. Always follow your doctor's instructions carefully and never share this medicine with others.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the blood pressure-lowering effects of this medicine and are at higher risk of dizziness, falls, and kidney impairment. Start with a lower dose and monitor blood pressure, kidney function, and potassium levels closely. Dose adjustments may be necessary based on renal function.
🤰 Pregnancy Planning (TTC)
This medicine is contraindicated during pregnancy. If you are planning to become pregnant, consult your doctor to switch to a safer alternative before conception. ACE inhibitors can cause fetal harm, especially in the second and third trimesters. Use effective contraception while taking this medicine if you are of childbearing potential.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine before any surgery. It may need to be temporarily stopped before surgery to avoid hypotension during anesthesia. Follow your doctor's instructions regarding when to resume the medicine after surgery.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. It may cause dry mouth or dizziness. Your dentist may need to take precautions if you require local anesthesia or have a history of angioedema. Maintain good oral hygiene and regular dental check-ups.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine may cause dizziness or lightheadedness, especially when you first start taking it or when the dose is increased. Avoid strenuous exercise or activities that require balance until you know how the medicine affects you. Stay well hydrated during exercise. If you experience dizziness, stop exercising and sit down. Consult your doctor before starting a new exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or fatigue, especially when you first start taking it. Avoid driving or operating heavy machinery until you know how it affects you. If your job involves operating machinery or driving, inform your employer and take necessary precautions. Most people can continue their normal activities once they adjust to the medicine. Regular monitoring and dose adjustments can minimize impact on daily life.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience serious side effects such as angioedema, severe hypotension, or kidney problems, seek immediate medical attention; your doctor may decide to stop the medicine. If you become pregnant, stop the medicine and contact your doctor immediately. In some cases, your doctor may switch you to a different medicine if side effects are bothersome or if your condition changes.
📅 Long-Term Use Effects
Long-term use of this medicine is generally safe and effective for managing high blood pressure and heart failure. However, regular monitoring of kidney function, potassium levels, and blood pressure is necessary. In some patients, long-term use may lead to a persistent dry cough or, rarely, kidney impairment. It is important to continue lifestyle modifications such as a low-salt diet, regular exercise, and weight management. Your doctor may adjust the dose or add other medicines over time to maintain optimal control. Do not stop the medicine without medical advice.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Diet, exercise, weight loss, and stress reduction can help lower blood pressure and may reduce the need for medication.
Evidence: Well-establishedAlternative class of blood pressure medicines that may be used if ACE inhibitors cause cough.
Evidence: Well-establishedAnother class of blood pressure medicines that can be used alone or in combination.
Evidence: Well-establishedOften used as first-line treatment for hypertension, alone or in combination.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, always inform your healthcare provider about all medicines you are taking before receiving any vaccine.
📦 Storage Guide
✅ DO
Store at room temperature (20-25°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight and moisture
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children and pets
❌ DON'T
Do not use after expiration date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with the prescription label clearly visible. Bring a copy of your prescription and a doctor's note stating your medical condition and the medicines you take. Keep the medicine in your carry-on luggage to avoid loss or temperature extremes. Store at room temperature and protect from moisture. If crossing time zones, adjust your dosing schedule gradually; consult your doctor for specific advice. Carry enough supply for your entire trip plus extra in case of delays. Check local customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts lowering blood pressure within 1 hour, with peak effect in 2-4 hours. However, full therapeutic effect may take 1-2 weeks. Your doctor will monitor your response and adjust the dose if needed.
A: Yes, you can take this medicine with or without food. Taking it at the same time each day helps maintain consistent levels. If it upsets your stomach, take it with a meal or snack.
A: Avoid potassium supplements and salt substitutes containing potassium unless prescribed. Limit alcohol as it can increase dizziness. Avoid NSAIDs like ibuprofen unless approved by your doctor, as they can reduce the effectiveness and increase kidney risk.
A: No, this medicine is contraindicated during pregnancy, especially in the second and third trimesters, as it can harm the fetus. If you are pregnant or planning to become pregnant, inform your doctor immediately.
A: No, do not stop taking this medicine suddenly without consulting your doctor. Stopping abruptly can cause your blood pressure to rise again, increasing the risk of complications.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: This medicine can cure high blood pressure permanently.
Fact: This medicine controls high blood pressure but does not cure it. Lifestyle changes and continued treatment are usually needed. - Myth: If I feel fine, I can stop taking this medicine.
Fact: High blood pressure often has no symptoms. Stopping the medicine can cause your blood pressure to rise again, increasing risk of complications. - Myth: This medicine causes kidney damage.
Fact: This medicine actually protects kidney function in many patients, especially those with diabetes. However, it can cause kidney problems in certain high-risk individuals, so monitoring is important. - Myth: I can take potassium supplements while on this medicine.
Fact: This medicine can increase potassium levels. Potassium supplements should only be taken if prescribed and monitored by a doctor.
🔄 Alternative Options
Generic Alternatives
- Benazepril 10 mg tablet
Brand Alternatives
- Apriace 10mg tablet