apagrel 5mg tablet

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Prasugrel (5mg)

🏭 Intas Pharmaceuticals Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Aug 24, 2026

📋 Prescription Required 💊 Generic Available

Medically Reviewed

SaathiMed Expert Panel | Aug 24, 2026

What is apagrel 5mg tablet used for?

Aplet (Prasugrel) is used to treat BLOOD RELATED. It contains Prasugrel (5mg), which Irreversibly inhibits the P2Y12 receptor on platelets, preventing ADP-mediated p. Always consult your doctor before use. Take as prescribed.

Generic Name: Prasugrel
Manufacturer: Intas Pharmaceuticals Ltd
Form: Allopathy
Pregnancy Category: A
Prescription Required: Yes

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💊 apagrel 5mg tablet Uses & Benefits

Acute coronary syndrome (ACS) managed with percutaneous coronary intervention (PCI), including patients with unstable angina or myocardial infarction

Off-label uses: Peripheral arterial disease, prevention of stent thrombosis (off-label in some regions)

📋 Drug Information

Generic Name(s)	Prasugrel
Brand Name	Aplet
Manufacturer	Intas Pharmaceuticals Ltd
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	BLOOD RELATED
Action Class	P2Y12 inhibitors (ADP receptor)
Route of Administration	Oral
Storage	Store at 20-25°C (68-77°F); protect from moisture and light
Shelf Life	As per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionRapidly absorbed after oral administration

DistributionWidely distributed; volume of distribution approximately 44-68 L

Protein BindingApproximately 98% bound to plasma proteins

MetabolismProdrug; extensively metabolized in the liver via CYP3A4 and CYP2B6 to active metabolite

Half-LifeActive metabolite half-life approximately 7 hours (range 2-15 hours)

ExcretionApproximately 68% excreted in urine, 27% in feces as inactive metabolites

BioavailabilityNot determined due to prodrug nature; active metabolite exposure is dose-proportional

Onset of ActionInhibition of platelet aggregation occurs within 30 minutes

Peak Plasma TimeActive metabolite peak plasma concentration at approximately 30 minutes (range 0.5-1 hour)

Duration of ActionPlatelet inhibition persists for 5-9 days (lifespan of platelets)

How It Works

Irreversibly inhibits the P2Y12 receptor on platelets, preventing ADP-mediated platelet aggregation

Mechanism Steps

1Prasugrel is a prodrug that is rapidly absorbed and hydrolyzed by esterases to an intermediate metabolite.

2The intermediate is then oxidized by CYP3A4 and CYP2B6 to form the active metabolite R-138727.

3The active metabolite irreversibly binds to the P2Y12 receptor on platelets.

💡 How to Take apagrel 5mg tablet

Follow your doctor's prescription exactly.

⚠️ Side Effects of apagrel 5mg tablet

✅ Common Side Effects

Bleeding (e.g., epistaxis, ecchymosis, hematoma)
Dyspnea
Headache
Dizziness
Nausea

🚨 Serious Side Effects

Major bleeding (intracranial, gastrointestinal, retroperitoneal)
Thrombotic thrombocytopenic purpura (rare)
Anaphylaxis

⚠️ Rare Side Effects

Angioedema
Interstitial lung disease
Thrombocytopenia

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug	Severity	Effect
Warfarin	Major	Increased bleeding risk
Aspirin	Moderate	Increased bleeding risk
NSAIDs	Major	Increased bleeding risk
Clopidogrel	Major	Increased bleeding risk
SSRIs	Moderate	Increased bleeding risk

🚨 Major Interactions

Warfarin
Heparin
NSAIDs
Clopidogrel
Ticagrelor
Thrombolytics
GP IIb/IIIa inhibitors

⚡ Moderate Interactions

Aspirin
SSRIs
SNRIs
Anticoagulants (e.g., rivaroxaban, apixaban)
CYP3A4 inducers (e.g., rifampin)
CYP3A4 inhibitors (e.g., ketoconazole)

ℹ️ Minor Interactions

Digoxin
Statins (except atorvastatin)
Calcium channel blockers

🍽️ Food Interactions

No significant food interactions; may be taken with or without food

🍷 Alcohol Interaction

May increase bleeding risk; avoid excessive alcohol consumption

🛡️ Safety & Warnings

🚫 Contraindications

Active pathological bleeding, history of stroke or transient ischemic attack, severe hepatic impairment, hypersensitivity to prasugrel

📊 Monitoring Parameters

Signs of bleeding, platelet count, hemoglobin, hematocrit, liver function tests

🤱 Lactation Safety

Unknown if excreted in breast milk; caution advised

💊 Overdose Management

No specific antidote; supportive care, platelet transfusion may be considered

⏰ Missed Dose

Take as soon as remembered; if almost time for next dose, skip missed dose; do not double dose

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 24, 2026

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🔄 Substitutes for apagrel 5mg tablet

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Alternative brands with exact same active ingredient (Prasugrel (5mg)):

Medical Note: Always consult your doctor before switching medications.