antipyr 20 dt tablet

4.5 (12 reviews)

Piroxicam (20mg)

🏭 Sansill Formulations 📦 Varies by brand 💊 Allopathy 📅 Updated: Aug 22, 2026

📋 Prescription Required 💊 Generic Available

Medically Reviewed

SaathiMed Expert Panel | Aug 22, 2026

What is antipyr 20 dt tablet used for?

Alkem Piroxicam Injection (Piroxicam) is used to treat PAIN ANALGESICS. It contains Piroxicam (20mg), which Inhibits cyclooxygenase (COX-1 and COX-2) enzymes, reducing prostaglandin synthe. Always consult your doctor before use. Take as prescribed.

Generic Name: Piroxicam
Manufacturer: Sansill Formulations
Form: Allopathy
Pregnancy Category: A
Prescription Required: Yes

💡 Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

💊 antipyr 20 dt tablet Uses & Benefits

Rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, acute gout, musculoskeletal pain, dysmenorrhea.

Off-label uses: Acute pain, postoperative pain, fever.

📋 Drug Information

Generic Name(s)	Piroxicam
Brand Name	Alkem Piroxicam Injection
Manufacturer	Sansill Formulations
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	PAIN ANALGESICS
Action Class	NSAID's- Non-Selective COX 1&2 Inhibitors (enolic acids)
Route of Administration	Intramuscular injection.
Storage	Store at 20-25°C (68-77°F); protect from light.
Shelf Life	As per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionRapidly absorbed after intramuscular injection; peak plasma concentrations achieved within 1-2 hours.

DistributionWidely distributed throughout the body; crosses the placenta and enters breast milk.

Protein BindingApproximately 99% bound to plasma proteins, primarily albumin.

MetabolismExtensively metabolized in the liver via hydroxylation and glucuronidation; CYP2C9 is the primary enzyme involved.

Half-LifeApproximately 50 hours (range 30-86 hours).

ExcretionPrimarily renal excretion of metabolites; less than 5% excreted unchanged.

Bioavailability100% after intramuscular injection.

Onset of ActionWithin 30-60 minutes.

Peak Plasma Time1-2 hours.

Duration of ActionUp to 24 hours.

How It Works

Inhibits cyclooxygenase (COX-1 and COX-2) enzymes, reducing prostaglandin synthesis.

Mechanism Steps

1Piroxicam binds to COX-1 and COX-2 enzymes.

2Inhibits conversion of arachidonic acid to prostaglandin H2.

3Reduces synthesis of prostaglandins, prostacyclin, and thromboxanes.

💡 How to Take antipyr 20 dt tablet

Follow your doctor's prescription exactly.

⚠️ Side Effects of antipyr 20 dt tablet

✅ Common Side Effects

Nausea
Dyspepsia
Abdominal pain
Diarrhea
Constipation
Headache
Dizziness

🚨 Serious Side Effects

GI bleeding
Peptic ulcer
Renal failure
Hypertension
Heart failure
Thrombotic events

⚠️ Rare Side Effects

Hepatotoxicity
Stevens-Johnson syndrome
Aplastic anemia
Agranulocytosis
Anaphylaxis

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug	Severity	Effect
Warfarin	Major	Increased bleeding risk
Aspirin	Major	Increased risk of GI ulceration and bleeding
Lithium	Major	Increased lithium levels and toxicity
Methotrexate	Major	Increased methotrexate toxicity
Anticoagulants	Major	Enhanced anticoagulant effect
ACE inhibitors	Moderate	Reduced antihypertensive effect
Diuretics	Moderate	Reduced diuretic effect
Corticosteroids	Moderate	Increased risk of GI ulceration
SSRIs	Moderate	Increased bleeding risk
Antacids	Minor	Possible reduced absorption of piroxicam
Digoxin	Minor	Possible increased digoxin levels
Phenytoin	Minor	Possible increased phenytoin levels

🚨 Major Interactions

Warfarin
Aspirin
Lithium
Methotrexate
Anticoagulants

⚡ Moderate Interactions

ACE inhibitors
Diuretics
Corticosteroids
SSRIs

ℹ️ Minor Interactions

Antacids
Digoxin
Phenytoin

🍽️ Food Interactions

No significant food interactions; may be taken with food to reduce GI upset.

🍷 Alcohol Interaction

Increased risk of gastrointestinal bleeding.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to piroxicam or NSAIDs, history of asthma, urticaria, or allergic-type reactions after aspirin/NSAIDs, active peptic ulcer disease, severe heart failure, severe renal impairment, perioperative pain in CABG surgery.

📊 Monitoring Parameters

Renal function, hepatic function, blood pressure, signs of GI bleeding, CBC.

🤱 Lactation Safety

Excreted in breast milk; avoid use or discontinue breastfeeding.

💊 Overdose Management

Symptomatic and supportive care; no specific antidote; consider activated charcoal if recent ingestion.

⏰ Missed Dose

If a dose is missed, take it as soon as remembered unless it is almost time for the next dose; do not double dose.

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 22, 2026

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🔄 Substitutes for antipyr 20 dt tablet

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Alternative brands with exact same active ingredient (Piroxicam (20mg)):

Medical Note: Always consult your doctor before switching medications.

⭐ User Reviews

Trusted Reviewer Jul 10, 2026

This medicine was effective for me. I followed the doctor's advice.

Certified Buyer Jul 10, 2026

Helpful and effective medicine as per my experience. Always consult a doctor.

Verified User Jul 10, 2026

Effective and reliable. Worked as expected.

Regular Customer Jul 10, 2026