annoflox nz syrup - Nitazoxanide (100mg/5ml) + Ofloxacin (50mg/5ml) medicine

Annoflox Nz Syrup: Complete Medicine Guide

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🏭 Annodyne Drugs 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 27, 2026
⚠️ Hepatotoxicity Risk 📋 Prescription Required 💊 Generic Available
Medically Reviewed
12 min read
Evidence: Limited
Reviewed by
SaathiMed Expert Panel | Oct 27, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
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When to Call Your Doctor IMMEDIATELY

  • Sudden severe pain, swelling, or inability to move a joint (possible tendon rupture).
  • Numbness, tingling, or burning in hands or feet (peripheral neuropathy).
  • Seizures, severe confusion, or hallucinations.
  • Difficulty breathing, swelling of face or throat, or severe rash (allergic reaction).
  • Yellowing of skin or eyes, dark urine, or severe abdominal pain (liver injury).
  • Bloody diarrhea or severe abdominal cramps.
  • Irregular heartbeat or fainting.

If experiencing severe symptoms, call emergency services immediately.

What is annoflox nz syrup used for?

This medicine is a combination of nitazoxanide and ofloxacin used to treat mixed gastrointestinal infections. It works by killing protozoa and bacteria. It is available as a syrup and is taken orally, usually twice daily for 3-7 days. It should only be used under a doctor's supervision.

  • Generic Name: Nitazoxanide + Ofloxacin
  • Manufacturer: Annodyne Drugs
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 annoflox nz syrup के बारे में (Hindi Summary)

उपयोग: यह दवा नाइटाज़ोक्सानाइड और ऑफ़्लोक्सासिन का संयोजन है, जिसका उपयोग मिश्रित जठरांत्र संक्रमण के इलाज के लिए किया जाता है। यह दस्त, पेट दर्द, और बुखार जैसे लक्षणों को कम करने में मदद करती है। यह केवल डॉक्टर के पर्चे पर ही ली जानी चाहिए।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट दर्द, दस्त, सिरदर्द और चक्कर आना शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें टेंडन टूटना, तंत्रिका क्षति, और एलर्जी प्रतिक्रियाएं शामिल हो सकती हैं। कोई भी गंभीर लक्षण होने पर तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। खुराक पूरी करें, भले ही आप बेहतर महसूस करें। दवा लेते समय शराब न लें। एंटासिड, दूध, या आयरन सप्लीमेंट के साथ इस दवा को न लें; कम से कम 2 घंटे का अंतराल रखें। यदि आपको टेंडन में दर्द, सूजन, या कमजोरी महसूस हो, तो तुरंत डॉक्टर से मिलें। धूप में जाने से बचें और सनस्क्रीन का उपयोग करें।

💡 Did You Know? The Indian pharmaceutical market is expected to reach $130 billion by 2030.

💊 annoflox nz syrup Uses & Benefits

[{"condition":"Infectious diarrhea","description":"Used for the treatment of diarrhea caused by susceptible mixed bacterial and protozoal pathogens, such as Giardia lamblia and enteroinvasive bacteria.","evidence":"Limited"},{"condition":"Intestinal amoebiasis","description":"May be used in combination for amoebic dysentery when bacterial co-infection is suspected.","evidence":"Limited"},{"condition":"Giardiasis","description":"Nitazoxanide component is active against Giardia, but ofloxacin is not typically used for this alone.","evidence":"Limited"}]

Off-label uses: []

Primary treatment for: Mixed gastrointestinal infections

Also treats: Giardiasis, Amoebiasis, Bacterial diarrhea

📋 Drug Information

Generic Name(s)Nitazoxanide + Ofloxacin
Brand NameAnnoflox NZ Syrup
ManufacturerAnnodyne Drugs
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassANTI INFECTIVES
Action ClassAntidiarrheal, Antiprotozoal, Fluoroquinolone Antibiotic
Route of AdministrationOral
StorageStore at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep the bottle tightly closed. Do not freeze.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Always prescribe this combination only when a mixed bacterial and protozoal infection is confirmed or strongly suspected.
2
Advise patients to take the syrup with food to minimize gastrointestinal upset.
3
Warn patients about the risk of tendon rupture and advise them to report any joint pain immediately.
4
Instruct patients to avoid antacids, dairy, and iron supplements within 2 hours of dosing.
5
Monitor renal function before and during therapy, especially in elderly patients.
6
Caution patients about photosensitivity and advise sun protection.
7
Emphasize completing the full course to prevent resistance.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Diarrhea
This medicine is commonly prescribed for infectious diarrhea.
Likely Use
✅
Abdominal cramps
May be used for cramps associated with gastrointestinal infections.
Likely Use
❌
Fever
This medicine is not a primary fever reducer.
Not Primary
❌
Common cold
This medicine is not effective for viral infections.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionNitazoxanide is rapidly absorbed from the gastrointestinal tract after oral administration and is hydrolyzed to its active metabolite, tizoxanide. Ofloxacin is well absorbed orally, with bioavailability of approximately 98%. Food may slightly delay absorption but does not significantly affect overall bioavailability.
DistributionNitazoxanide and its metabolites are widely distributed in body tissues. Ofloxacin distributes well into most body fluids and tissues, including lung, kidney, prostate, and bile. Protein binding of ofloxacin is approximately 20-30%. Nitazoxanide metabolite tizoxanide is highly protein-bound (>99%).
Protein BindingTizoxanide (active metabolite of nitazoxanide) is >99% bound to plasma proteins. Ofloxacin is approximately 20-30% bound to plasma proteins.
MetabolismNitazoxanide is rapidly hydrolyzed to tizoxanide, which is then conjugated to glucuronide and sulfate metabolites. Ofloxacin is minimally metabolized in the liver, with less than 10% metabolized to desmethyl ofloxacin and ofloxacin N-oxide.
Half-LifeThe elimination half-life of tizoxanide is approximately 1.5 hours. The elimination half-life of ofloxacin is approximately 4-5 hours in patients with normal renal function.
ExcretionNitazoxanide metabolites are excreted primarily in urine and feces. Ofloxacin is excreted largely unchanged in urine (70-80%) and to a lesser extent in feces.
BioavailabilityOfloxacin oral bioavailability is approximately 98%. Nitazoxanide bioavailability is not well established but is considered adequate for therapeutic effect.
Onset of ActionOnset of action for nitazoxanide is typically within 1-2 hours after oral administration. Ofloxacin onset is also within 1-2 hours.
Peak Plasma TimePeak plasma concentration of tizoxanide is reached in about 1-2 hours. Peak plasma concentration of ofloxacin is reached in 1-2 hours.
Duration of ActionThe duration of action depends on the dosing interval. With typical twice-daily dosing, therapeutic effects are maintained throughout the day.

How It Works

This medicine combines two agents with distinct mechanisms. Nitazoxanide is a synthetic antiprotozoal that inhibits pyruvate:ferredoxin oxidoreductase (PFOR), an enzyme essential for anaerobic energy metabolism in protozoa and anaerobic bacteria. This disrupts their energy production and leads to cell death. Ofloxacin is a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase and topoisomerase IV, enzymes required for DNA replication, transcription, repair, and recombination. This leads to inhibition of bacterial growth and death. The combination targets both protozoal and bacterial components of mixed infections.

Mechanism Steps

1
Nitazoxanide uptake and activation: Nitazoxanide is absorbed and taken up by susceptible protozoa and anaerobic bacteria, where it is reduced by PFOR.
2
Inhibition of energy metabolism: The reduced nitazoxanide metabolites disrupt the electron transport chain and ATP production, leading to cell death of protozoa and anaerobes.
3
Ofloxacin entry into bacteria: Ofloxacin penetrates bacterial cells and binds to DNA gyrase and topoisomerase IV.
4
Inhibition of DNA replication: Binding of ofloxacin to these enzymes blocks DNA replication and transcription, causing bacterial cell death.

💡 How to Take annoflox nz syrup

Strength: Each 5 mL of syrup contains Nitazoxanide 100 mg and Ofloxacin 50 mg.

1Shake the bottle well before each use.
2Use a calibrated measuring cup or spoon to measure the dose accurately.
3Take this medicine orally, with or without food, but taking it with food may reduce stomach upset.
4Do not take with antacids, dairy products, or iron supplements within 2 hours of this medicine.
5Swallow the syrup directly; do not mix with other liquids unless instructed by your doctor.
6Wash the measuring cup after each use.
7Complete the full course as prescribed, even if you feel better.

Dosage Information

Adult DosageThe dosage of this medicine must be individualized by a qualified clinician based on the specific indication, severity of infection, patient's age, weight, renal and hepatic function, and clinical response. Typically, it is administered orally twice daily for 3 to 7 days. Do not self-medicate. Follow your doctor's prescription exactly.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician. This combination is generally not recommended for children under 18 years due to the risk of fluoroquinolone-related adverse effects on cartilage development.
Elderly DosageElderly patients may have reduced renal function and are at higher risk of tendon rupture, CNS effects, and QT prolongation. Dose adjustment may be necessary based on renal function. Use with caution.
Renal ImpairmentIn patients with renal impairment (creatinine clearance <50 mL/min), the dose of ofloxacin should be adjusted. For creatinine clearance 20-50 mL/min, the usual dose may be given once daily. For creatinine clearance <20 mL/min, the dose may need further reduction. Nitazoxanide does not require renal dose adjustment.
Hepatic ImpairmentNo specific dose adjustment is established for nitazoxanide in hepatic impairment. Ofloxacin is minimally metabolized in the liver, so dose adjustment is not typically required for mild to moderate hepatic impairment. Use with caution in severe hepatic impairment.
Maximum Daily DoseThe maximum daily dose should not exceed the prescribed amount. For ofloxacin, the maximum daily dose is typically 400 mg. For nitazoxanide, the maximum daily dose is typically 1000 mg. However, this combination's maximum daily dose must be determined by a clinician.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset.
Dairy products
Avoid within 2 hours
Calcium reduces absorption of ofloxacin.
Iron-fortified cereals
Separate by 2 hours
Iron chelates ofloxacin.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of annoflox nz syrup

✅ Common Side Effects

Nausea (Common (5-10%))
Take with food to reduce nausea. If it persists, consult your doctor.
Abdominal pain (Common (5-10%))
Usually temporary. If severe or persistent, contact your doctor.
Headache (Common (5-10%))
Rest and stay hydrated. Consult doctor if severe.
Dizziness (Common (5-10%))
Avoid driving or operating machinery until you know how it affects you.
Diarrhea (Common (5-10%))
Stay hydrated. If diarrhea becomes severe or bloody, seek medical attention.

🚨 Serious Side Effects

Tendon rupture (Rare (<0.1%))
Stop taking this medicine and seek immediate medical attention if you experience sudden pain, swelling, or inability to move a joint.
Peripheral neuropathy (Rare (<0.1%))
Report symptoms like numbness, tingling, burning, or weakness in hands or feet to your doctor immediately.
Central nervous system effects (seizures, confusion) (Rare (<0.1%))
Seek immediate medical help if you experience seizures, severe confusion, or hallucinations.
Severe allergic reactions (anaphylaxis) (Rare (<0.1%))
Call emergency services if you have difficulty breathing, swelling of face or throat, or a severe rash.
Liver injury (Rare (<0.1%))
Report yellowing of skin or eyes, dark urine, or severe abdominal pain to your doctor immediately.

⚠️ Rare Side Effects

Photosensitivity
Avoid sun exposure and use sunscreen. Report severe sunburn to your doctor.
Blood dyscrasias
Report unusual bruising or bleeding to your doctor.
QT prolongation
Inform your doctor if you have palpitations or fainting spells.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Antacids Major
Warfarin Major
Theophylline Major
NSAIDs Major
Corticosteroids Major
Caffeine Moderate
Cyclosporine Moderate
Oral hypoglycemics Moderate
Phenytoin Moderate
Multivitamins Minor

🚨 Major Interactions

  • Antacids, sucralfate, iron, zinc
  • Warfarin
  • Theophylline
  • NSAIDs
  • Corticosteroids

⚡ Moderate Interactions

  • Caffeine
  • Cyclosporine
  • Oral hypoglycemics
  • Phenytoin

🍷 Alcohol Interaction

Alcohol should be avoided while taking this medicine. Alcohol can increase the risk of central nervous system side effects such as dizziness, drowsiness, and seizures. It may also worsen gastrointestinal irritation.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known hypersensitivity to nitazoxanide, ofloxacin, or other fluoroquinolones","History of tendon disorders associated with fluoroquinolone use","Myasthenia gravis","Children under 18 years (unless specifically prescribed by a specialist)","Pregnancy and lactation (unless benefits outweigh risks)","Severe renal impairment (dose adjustment required)"]

⚠️ Warnings & Precautions

["Fluoroquinolones can cause tendonitis and tendon rupture, especially in older adults and those on corticosteroids.","May cause peripheral neuropathy; discontinue if symptoms occur.","Can exacerbate myasthenia gravis; avoid use.","May cause CNS effects including seizures; use caution in patients with epilepsy.","Avoid excessive sun exposure due to photosensitivity risk.","May cause hypoglycemia in diabetic patients; monitor blood glucose.","Do not use for viral infections.","Complete the full course as prescribed."]

🤱 Lactation Safety

Not established from the available information. Ofloxacin is excreted in breast milk. Because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

💊 Overdose Management

In case of overdose, seek immediate medical attention. Symptoms may include nausea, vomiting, dizziness, and seizures. Treatment is supportive and symptomatic. There is no specific antidote. Hemodialysis may be considered for ofloxacin overdose but is not effective for nitazoxanide.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not share it with others. Complete the full course even if you feel better. Avoid alcohol while taking this medicine. Do not take antacids, sucralfate, or iron supplements within 2 hours before or after taking this medicine, as they can reduce the absorption of ofloxacin. Inform your doctor if you have kidney or liver problems, diabetes, epilepsy, or a history of tendon problems. Avoid excessive sunlight and use sunscreen, as ofloxacin can cause photosensitivity. If you experience pain, swelling, or rupture of a tendon, stop taking this medicine and contact your doctor immediately. Do not drive or operate heavy machinery if you feel dizzy. Keep out of reach of children.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are at higher risk of tendon rupture, renal impairment, and CNS effects. Dose adjustment based on renal function is often necessary. Monitor closely for adverse effects.

🤰 Pregnancy Planning (TTC)

This medicine is not recommended during pregnancy or when planning pregnancy. Fluoroquinolones may affect fetal cartilage development. Consult your doctor for alternative treatments.

🏥 Post-Surgery Considerations

Use with caution after surgery, especially if the patient is on other medications. Monitor for interactions and side effects. Ensure adequate hydration.

🦷 Dental Procedures

Inform your dentist if you are taking this medicine. It may interact with other medications used during dental procedures. No specific precautions are established.

💚 Lifestyle Tips for Better Results

🏃
Stay well hydrated to help flush out the infection.
🥗
Eat a bland diet to avoid irritating the stomach.
😴
Get plenty of rest to support your immune system.
💧
Practice good hand hygiene to prevent spreading infection.
🧘
Avoid alcohol and caffeine while taking this medicine.
🌞
Use sunscreen and protective clothing when outdoors.

🏋️ Exercise Considerations

Avoid strenuous exercise or heavy lifting while taking this medicine, as it may increase the risk of tendon rupture. If you experience joint pain, stop exercising and consult your doctor.

🥗 Diet Recommendations

Eat small, frequent meals.
Include probiotic-rich foods like yogurt after completing the course.
Avoid spicy and fatty foods.
Drink plenty of fluids.
Avoid dairy products within 2 hours of taking the medicine.

💼 Impact on Daily Work & Life

This medicine may cause dizziness and fatigue. Avoid driving or operating heavy machinery until you know how it affects you. Take sick leave if needed to rest and recover.

🛑 When to Stop This Medicine

Do not stop taking this medicine without consulting your doctor. Complete the full prescribed course even if you feel better. If you experience serious side effects such as tendon pain, numbness, or seizures, stop the medicine and seek immediate medical attention.

📅 Long-Term Use Effects

Long-term use of this medicine is not recommended. Prolonged use of antibiotics can lead to bacterial resistance and superinfections. Fluoroquinolones can cause persistent tendon and nerve damage. Regular monitoring of renal and liver function may be required if used for extended periods.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Oral rehydration therapy

Essential for managing dehydration from diarrhea.

Evidence: Well-established
Probiotics

May help restore gut flora after antibiotic treatment.

Evidence: Moderate
Zinc supplementation

Can reduce duration of diarrhea in children.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

No specific vaccine interactions are established. However, antibiotics may reduce the efficacy of live bacterial vaccines such as typhoid vaccine. Consult your doctor for timing.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid temperature extremes. Store at room temperature and protect from light. If crossing time zones, continue your dosing schedule as close to the original times as possible. Check local customs regulations for bringing prescription medicines.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 35-year-old man with persistent diarrhea and abdominal cramps.
He was prescribed this medicine after stool tests showed mixed infection. He took it with food twice daily and completed the 5-day course. His symptoms improved within 3 days, and he had no side effects.
💡 Lesson: Taking the medicine with food and completing the full course led to a successful outcome.
👤 A 60-year-old woman with a history of kidney disease.
She was prescribed this medicine for a gastrointestinal infection. Her doctor adjusted the dose based on her renal function. She was monitored closely and recovered without complications.
💡 Lesson: Dose adjustment and monitoring are crucial in patients with kidney disease.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: You may start feeling better within 1-2 days, but it is important to complete the full course as prescribed.

Q: Can I take this medicine with food?

A: Yes, taking it with food can reduce stomach upset. However, avoid dairy products within 2 hours of taking this medicine.

Q: Is this medicine safe for children?

A: This medicine is generally not recommended for children under 18 years due to the risk of fluoroquinolone-related side effects. Consult a pediatrician.

Q: What should I do if I miss a dose?

A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for annoflox nz syrup

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can cure any type of diarrhea.
    Fact: This medicine is only effective for specific bacterial and protozoal infections. It does not work for viral diarrhea or other causes.
  • Myth: You can stop taking this medicine once you feel better.
    Fact: You must complete the full prescribed course to prevent recurrence and resistance.
  • Myth: This medicine is safe for children.
    Fact: Fluoroquinolones are generally avoided in children due to potential joint and tendon problems. Consult a pediatrician.

🔄 Alternative Options

Generic Alternatives

  • Nitazoxanide + Ofloxacin combination (various manufacturers)

Brand Alternatives

  • Annoflox NZ Syrup

📊 Comparison with Similar Medicines

[{"medicine":"Annoflox NZ Syrup","composition":"Nitazoxanide + Ofloxacin","route":"Oral","primary_use":"Mixed GI infections"},{"medicine":"Nitazoxanide alone","composition":"Nitazoxanide","route":"Oral","primary_use":"Protozoal infections"},{"medicine":"Ofloxacin alone","composition":"Ofloxacin","route":"Oral","primary_use":"Bacterial infections"}]

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