PL NZ Syrup: Complete Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Sudden severe pain, swelling, or inability to move a joint (possible tendon rupture)
- Rash, itching, swelling of face or throat, or difficulty breathing (severe allergic reaction)
- Seizures or convulsions
- Severe, persistent diarrhea with fever or abdominal cramps (possible C. difficile infection)
- Yellowing of skin or eyes, dark urine, or severe fatigue (liver injury)
- Numbness, tingling, or burning in hands or feet (peripheral neuropathy)
- Sudden severe chest, back, or abdominal pain (possible aortic aneurysm)
If experiencing severe symptoms, call emergency services immediately.
What is glofty-n syrup used for?
This medicine is a combination of nitazoxanide and ofloxacin used to treat mixed protozoal and bacterial gastrointestinal infections. It works by killing protozoa and bacteria. Take it exactly as prescribed, with food, and complete the full course.
- Generic Name: Nitazoxanide (100mg/5ml) + Ofloxacin (50mg/5ml)
- Manufacturer: Globus Remedies Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 glofty-n syrup के बारे में (Hindi Summary)
उपयोग: यह दवा नाइटाज़ोक्सानाइड और ऑफ़लोक्सासिन का संयोजन है, जिसका उपयोग पेट और आंतों के मिश्रित प्रोटोज़ोआ और बैक्टीरियल संक्रमणों के इलाज के लिए किया जाता है। यह दस्त, पेट दर्द, और ऐंठन में राहत देती है। यह दवा कीड़े और बैक्टीरिया को मारती है। इसे डॉक्टर के निर्देशानुसार ही लें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट दर्द, दस्त, सिरदर्द और चक्कर आना शामिल हैं। गंभीर दुष्प्रभावों में टेंडन टूटना, एलर्जी, दौरे, और लीवर की समस्या शामिल हो सकती है। कोई भी गंभीर लक्षण होने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। खुराक पूरी करें, बीच में न छोड़ें। दवा को भोजन के साथ लें। पर्याप्त पानी पिएं। एंटासिड, आयरन या जिंक सप्लीमेंट के साथ इस दवा को न लें। शराब न पिएं। गुर्दे या लीवर की बीमारी हो तो डॉक्टर को बताएं। बच्चों को बिना डॉक्टर की सलाह के न दें।
💊 glofty-n syrup Uses & Benefits
[{"condition":"Giardiasis","description":"This medicine is used to treat diarrhea and other gastrointestinal symptoms caused by the protozoan parasite Giardia lamblia.","evidence":"Well-established for nitazoxanide component; ofloxacin adds antibacterial coverage."},{"condition":"Amebiasis","description":"It is prescribed for intestinal amebiasis caused by Entamoeba histolytica, helping to resolve diarrhea, abdominal pain, and dysentery.","evidence":"Well-established for nitazoxanide; ofloxacin may cover secondary bacterial infections."},{"condition":"Mixed protozoal and bacterial diarrhea","description":"This combination is sometimes used when a mixed infection is suspected or confirmed, targeting both protozoa and susceptible bacteria.","evidence":"Limited; combination use is based on clinical judgment."}]
Off-label uses: [{"condition":"Cryptosporidiosis in immunocompetent patients","description":"Nitazoxanide alone has been used off-label for cryptosporidiosis, but the combination with ofloxacin is not standard.","evidence":"Limited"},{"condition":"Helicobacter pylori eradication","description":"Ofloxacin is sometimes included in second-line regimens for H. pylori, but this specific combination is not standard.","evidence":"Limited"}]
Primary treatment for: Mixed protozoal and bacterial gastrointestinal infections
Also treats: Giardiasis, Amebiasis, Bacterial diarrhea
📋 Drug Information
| Generic Name(s) | Nitazoxanide (100mg/5ml) + Ofloxacin (50mg/5ml) |
| Brand Name | glofty-n syrup |
| Manufacturer | Globus Remedies Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C. Protect from light and moisture. Keep the bottle tightly closed. Do not freeze. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with different mechanisms. Nitazoxanide works by inhibiting the pyruvate-ferredoxin oxidoreductase enzyme in protozoa, which disrupts their energy metabolism and prevents them from growing and multiplying. Ofloxacin is a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication, transcription, repair, and recombination. This leads to bacterial cell death. Together, they target both protozoal and bacterial pathogens in the gastrointestinal tract.
Mechanism Steps
💡 How to Take glofty-n syrup
Strength: Each 5 mL of syrup contains Nitazoxanide 100 mg and Ofloxacin 50 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 5 mL to 10 mL orally twice daily for 3 to 5 days, depending on the severity of the infection and the patient's response. However, the exact dose and duration must be individualized by a qualified clinician based on the specific indication, age, weight, renal and hepatic function, and clinical response. Do not self-medicate. Always follow your doctor's prescription. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. Ofloxacin is generally not recommended for children under 18 years due to the risk of cartilage damage. |
| Elderly Dosage | Elderly patients may require dose adjustment based on renal function. Ofloxacin is primarily excreted by the kidneys, and renal function declines with age. Monitor renal function and adjust dose accordingly. Elderly patients are also at higher risk of tendon rupture and CNS effects. |
| Renal Impairment | Dose adjustment is required in patients with renal impairment. For ofloxacin, the dose should be reduced in patients with creatinine clearance less than 50 mL/min. Consult your doctor for specific dosing recommendations based on your renal function. |
| Hepatic Impairment | No specific dose adjustment is established for hepatic impairment. Use with caution and monitor liver function. Consult your doctor. |
| Maximum Daily Dose | The maximum daily dose should not exceed the prescribed amount. For adults, the usual maximum is 10 mL twice daily, but this must be confirmed by your doctor. Do not exceed the recommended dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of glofty-n syrup
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Antacids | Major | |
| Warfarin | Major | |
| NSAIDs | Major | |
| Theophylline | Major | |
| Corticosteroids | Major | |
| Caffeine | Moderate | |
| Cyclosporine | Moderate | |
| Oral hypoglycemics | Moderate | |
| Phenytoin | Moderate | |
| Probenecid | Minor |
🚨 Major Interactions
- Antacids, sucralfate, iron, zinc
- Warfarin
- NSAIDs (e.g., ibuprofen, diclofenac)
- Theophylline
- Corticosteroids
⚡ Moderate Interactions
- Caffeine
- Cyclosporine
- Oral hypoglycemics
- Phenytoin
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol can increase the risk of stomach bleeding, liver problems, and central nervous system side effects such as dizziness and drowsiness. It may also worsen the underlying infection and delay recovery.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy to nitazoxanide, ofloxacin, or other quinolone antibiotics","History of tendon disorders related to fluoroquinolone use","Myasthenia gravis","Severe renal impairment (creatinine clearance
⚠️ Warnings & Precautions
["Fluoroquinolones, including ofloxacin, can cause disabling and potentially irreversible serious adverse reactions involving tendons, muscles, joints, nerves, and central nervous system. Reserve use for patients with no alternative treatment options.","Tendon rupture can occur during or after treatment, especially in patients over 60, those taking corticosteroids, and transplant recipients.","Ofloxacin can exacerbate muscle weakness in patients with myasthenia gravis.","Avoid excessive sunlight and UV exposure as ofloxacin can cause photosensitivity.","May cause dizziness and lightheadedness; avoid driving or operating machinery until you know how it affects you.","Prolonged use may result in overgrowth of non-susceptible organisms, including fungi.","Use with caution in patients with epilepsy or other CNS disorders.","Monitor blood glucose closely in diabetic patients as fluoroquinolones can cause severe hypoglycemia.","Do not use in patients with a history of aortic aneurysm or risk factors for aortic aneurysm.","Ensure adequate hydration during treatment."]
🤱 Lactation Safety
Not established from the available information. Ofloxacin is excreted in breast milk and may cause serious adverse reactions in nursing infants. Nitazoxanide may also pass into breast milk. Consult your doctor before breastfeeding while taking this medicine.
💊 Overdose Management
Overdose of this medicine may cause nausea, vomiting, abdominal pain, dizziness, and seizures. If you suspect an overdose, seek emergency medical attention immediately. Treatment is supportive and symptomatic. There is no specific antidote. Activated charcoal may be considered if ingestion is recent. Monitor vital signs, renal function, and ECG. Hemodialysis may be considered for ofloxacin overdose in patients with renal failure.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not skip doses or stop early, even if you feel better, because incomplete treatment can lead to relapse or resistance. Shake the bottle well before each use to ensure the medicine is evenly mixed. Use a proper measuring cup or spoon to measure the dose accurately. Take this medicine with food to reduce stomach upset. Drink plenty of water throughout the day. Avoid taking antacids, iron supplements, or multivitamins containing zinc or iron within two hours of this medicine, as they can reduce its absorption. Do not take this medicine with dairy products or calcium-fortified juices at the same time. Avoid alcohol while taking this medicine, as it may increase the risk of stomach bleeding and liver problems. If you have kidney or liver disease, your doctor may need to adjust your dose. Do not share this medicine with others, even if they have similar symptoms. Keep this medicine out of the reach of children. Store it at room temperature, away from direct sunlight and moisture. If you miss a dose, take it as soon as you remember, but if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose. If you experience any severe side effects such as tendon pain, numbness, or seizures, stop the medicine and contact your doctor immediately. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding, as this medicine may not be suitable for you. Regular monitoring of kidney and liver function may be needed during treatment.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of tendon rupture, kidney impairment, and central nervous system side effects. Dose adjustment based on renal function is often necessary. Monitor renal function and watch for signs of confusion, dizziness, or tendon pain.
🤰 Pregnancy Planning (TTC)
This medicine is not recommended during pregnancy or when planning pregnancy unless clearly needed. Ofloxacin may affect fetal cartilage development. Consult your doctor for alternative treatments if you are pregnant or planning to become pregnant.
🏥 Post-Surgery Considerations
If you are scheduled for surgery, inform your surgeon that you are taking this medicine. Ofloxacin may interact with anesthetics and increase the risk of tendon rupture. Your doctor may advise you to stop the medicine before surgery.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. Ofloxacin may increase the risk of bleeding and interact with certain antibiotics used in dentistry. Your dentist may need to adjust your treatment plan.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise while taking this medicine, especially if you experience dizziness, fatigue, or tendon pain. Fluoroquinolones can increase the risk of tendon injury during physical activity. Consult your doctor before resuming exercise.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness, drowsiness, or confusion. Avoid driving, operating heavy machinery, or performing tasks that require mental alertness until you know how it affects you. Take rest as needed. Inform your employer if you need time off to recover.
🛑 When to Stop This Medicine
Stop taking this medicine and consult your doctor immediately if you experience any serious side effects such as tendon pain, severe allergic reaction, seizures, or signs of liver injury. Do not stop the medicine without consulting your doctor, as incomplete treatment can lead to recurrence or resistance.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended. Prolonged use of ofloxacin can lead to bacterial resistance, secondary infections, tendon damage, and peripheral neuropathy. Nitazoxanide is generally well-tolerated for short courses. If long-term therapy is required, regular monitoring of kidney and liver function, blood counts, and neurological assessments is advised. Consult your doctor for any long-term use.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Essential for managing dehydration caused by diarrhea.
Evidence: Well-establishedMay help restore gut flora and reduce diarrhea duration.
Evidence: ModerateRecommended in children with diarrhea to reduce severity and duration.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no specific vaccine interactions reported with this medicine. However, if you are due for any live vaccines, consult your doctor as antibiotics may affect the immune response to certain vaccines.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep the bottle tightly closed
❌ DON'T
Do not use after the expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with the prescription label intact. Bring a copy of your prescription in case you need to show it to customs or a doctor. Store it at room temperature and protect it from extreme heat or cold. If you are crossing time zones, continue taking the medicine at the same intervals as prescribed; you may need to adjust the timing gradually. Do not pack it in checked luggage; keep it in your carry-on. If you are traveling to areas with limited medical facilities, ensure you have enough supply for the entire trip.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling better within 24 to 48 hours, but you must complete the full course as prescribed.
A: Yes, take it with food to reduce stomach upset. Avoid dairy products at the same time.
A: Take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
A: Ofloxacin is generally not recommended for children under 18 years. Consult a pediatrician.
A: No, avoid alcohol as it can increase the risk of side effects and worsen your condition.
🤔 Common Patient Concerns
🔄 Substitutes for glofty-n syrup
View AllAlternative brands with exact same active ingredient:
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mapcin nz syrupAster Medipharm Pvt Ltd ₹39.28 32.4% CHEAPER
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oflotag n oral suspensionInnovative Pharmaceuticals ₹46.64 19.8% CHEAPER
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zoflo-nz syrupAllenge India ₹46.90 19.3% CHEAPER
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butaflox nz oral suspensionZenstar Life Sciences ₹48.19 17.1% CHEAPER
-
arviflox n syrupArvincare Pharma ₹63.00 8.4% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure any type of diarrhea.
Fact: This medicine is only effective against specific protozoal and bacterial infections. It is not effective for viral diarrhea or diarrhea caused by other conditions. - Myth: You can stop taking this medicine as soon as you feel better.
Fact: You must complete the full course as prescribed to prevent recurrence and resistance, even if symptoms improve. - Myth: This medicine is safe for children.
Fact: Ofloxacin is generally not recommended for children under 18 years due to the risk of cartilage damage. Consult a pediatrician.
🔄 Alternative Options
Generic Alternatives
- Nitazoxanide + Ofloxacin syrup (generic versions may be available)