anibret 250mg tablet - Terbinafine (250mg) medicine

anibret 250mg tablet - Uses, Price, Side Effects & Substitutes

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๐Ÿญ Esma Formulations ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Jun 30, 2026
โš ๏ธ Hepatotoxicity Risk ๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
SaathiMed Expert Panel | Jun 30, 2026

What is anibret 250mg tablet used for?

Af-ter Lotion (Terbinafine) is used to treat ANTI INFECTIVES. It contains Terbinafine (250mg), which Inhibits squalene epoxidase, blocking ergosterol synthesis in fungal cell membra. Always consult your doctor before use. Take as prescribed.

  • Generic Name: Terbinafine
  • Manufacturer: Esma Formulations
  • Form: Allopathy
  • Pregnancy Category: B
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? Over 80% of the antiretroviral drugs used globally to combat AIDS are supplied by Indian pharmaceutical companies.

๐Ÿ’Š anibret 250mg tablet Uses & Benefits

Topical treatment of dermatophyte infections (tinea pedis, tinea cruris, tinea corporis)

Off-label uses: Tinea versicolor, Cutaneous candidiasis

๐Ÿ“‹ Drug Information

Generic Name(s)Terbinafine
Brand NameAf-ter Lotion
ManufacturerEsma Formulations
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassANTI INFECTIVES
Action ClassFungal ergosterol synthesis inhibitor
Route of AdministrationTopical
StorageStore at 20-25ยฐC (68-77ยฐF); protect from light
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionApproximately 70-80% absorbed through skin; systemic absorption minimal (<5%)
DistributionDistributes into stratum corneum, epidermis, dermis, and hair follicles; high affinity for keratin
Protein Binding>99% bound to plasma proteins
MetabolismHepatic via CYP450 enzymes (CYP2C9, CYP1A2, CYP3A4) to inactive metabolites
Half-Life11-17 hours (topical); 200-400 hours from skin
ExcretionPrimarily renal (70-80% as metabolites); some fecal
BioavailabilitySystemic bioavailability <5% after topical application
Onset of ActionWithin 1-2 weeks of regular application
Peak Plasma TimeNot applicable (minimal systemic absorption)
Duration of ActionSustained for several days after application

How It Works

Inhibits squalene epoxidase, blocking ergosterol synthesis in fungal cell membrane

Mechanism Steps

1Terbinafine enters fungal cell
2Binds to squalene epoxidase
3Inhibits conversion of squalene to lanosterol

๐Ÿ’ก How to Take anibret 250mg tablet

Follow your doctor's prescription exactly.

โš ๏ธ Side Effects of anibret 250mg tablet

โœ… Common Side Effects

  • Application site irritation
  • Redness
  • Itching
  • Burning

๐Ÿšจ Serious Side Effects

  • Severe allergic reaction
  • Angioedema
  • Bullous dermatitis

โš ๏ธ Rare Side Effects

  • Contact dermatitis
  • Urticaria

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
Warfarin Major Increased INR and bleeding risk
Cimetidine Major Decreased terbinafine clearance
Rifampin Major Increased terbinafine clearance
Cyclosporine Moderate Decreased cyclosporine levels
Oral contraceptives Moderate Possible menstrual irregularities
Theophylline Moderate Increased theophylline levels
Caffeine Minor Decreased caffeine clearance
Alcohol Minor No significant effect

๐Ÿšจ Major Interactions

  • Warfarin
  • Cimetidine
  • Rifampin

โšก Moderate Interactions

  • Cyclosporine
  • Oral contraceptives
  • Theophylline

โ„น๏ธ Minor Interactions

  • Caffeine
  • Alcohol

๐Ÿฝ๏ธ Food Interactions

No significant food interactions

๐Ÿท Alcohol Interaction

No known interaction

๐Ÿ›ก๏ธ Safety & Warnings

๐Ÿšซ Contraindications

Hypersensitivity to terbinafine or any component

๐Ÿ“Š Monitoring Parameters

Clinical improvement; signs of irritation or allergic reaction

๐Ÿคฑ Lactation Safety

Excreted in breast milk; use with caution

๐Ÿ’Š Overdose Management

Unlikely with topical use; if ingested, symptomatic and supportive care

โฐ Missed Dose

Apply as soon as remembered; skip if almost time for next dose

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Reviewed: Jun 30, 2026

๐Ÿ”— View Profile

๐Ÿ”„ Substitutes for anibret 250mg tablet

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Alternative brands with exact same active ingredient (Terbinafine (250mg)):

Medical Note: Always consult your doctor before switching medications.

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