angiwell 6.4mg tablet - Nitroglycerin (6.4mg) medicine

Angiwel 6.4mg Tablet: Complete Medicine Guide

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🏭 Corona Remedies Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 17, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Well-established for prevention of angina.
Reviewed by
SaathiMed Expert Panel | Oct 17, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Severe chest pain that does not respond to rest or sublingual nitroglycerin
  • Fainting or loss of consciousness
  • Severe dizziness or lightheadedness
  • Bluish discoloration of lips, skin, or nails
  • Shortness of breath or difficulty breathing
  • Irregular or very slow heartbeat
  • Swelling of face, lips, or throat

If experiencing severe symptoms, call emergency services immediately.

What is angiwell 6.4mg tablet used for?

This medicine is an oral nitroglycerin tablet used to prevent angina (chest pain) in adults. It works by relaxing blood vessels to improve blood flow to the heart. It is taken before activities that may trigger angina. It is not for immediate relief of an acute attack.

  • Generic Name: Nitroglycerin
  • Manufacturer: Corona Remedies Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 angiwell 6.4mg tablet के बारे में (Hindi Summary)

उपयोग: यह दवा एंजाइना पेक्टोरिस (सीने में दर्द) को रोकने के लिए इस्तेमाल की जाती है। यह रक्त वाहिकाओं को फैलाकर हृदय तक रक्त का प्रवाह बढ़ाती है और हृदय पर दबाव कम करती है। इसे उन गतिविधियों से पहले लिया जाता है जो एंजाइना को ट्रिगर कर सकती हैं। यह तीव्र एंजाइना हमले के तत्काल उपचार के लिए नहीं है।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में सिरदर्द, चक्कर आना, लालिमा, हल्का सिर घूमना और निम्न रक्तचाप शामिल हैं। गंभीर दुष्प्रभाव जैसे गंभीर निम्न रक्तचाप, बेहोशी और मेथेमोग्लोबिनेमिया दुर्लभ हैं लेकिन तत्काल चिकित्सा ध्यान देने की आवश्यकता होती है।

सुरक्षा सलाह: इस दवा को हमेशा डॉक्टर के निर्देशानुसार ही लें। इसे चबाएं या तोड़ें नहीं। शराब के साथ इसका सेवन न करें क्योंकि इससे रक्तचाप बहुत कम हो सकता है। अचानक उठने या बैठने से बचें। यदि आप गर्भवती हैं या स्तनपान करा रही हैं तो डॉक्टर को बताएं। सिल्डेनाफिल, टैडालाफिल या वर्डेनाफिल लेने के 24-48 घंटे के भीतर इस दवा का सेवन न करें।

💡 Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

💊 angiwell 6.4mg tablet Uses & Benefits

  • [{"condition":"Prevention of angina pectoris","description":"This medicine is used prophylactically to prevent angina attacks in patients with coronary artery disease.
  • It is taken before activities that may trigger chest pain.","evidence":"Well-established"},{"condition":"Chronic stable angina","description":"Used as part of a treatment regimen to reduce the frequency and severity of angina attacks in patients with chronic stable angina.","evidence":"Well-established"}]

Off-label uses: [{"condition":"Esophageal spasm","description":"Sometimes used off-label to relieve esophageal spasm due to its smooth muscle relaxant properties.","evidence":"Limited"},{"condition":"Anal fissure","description":"Topical nitroglycerin is used off-label for anal fissures, but oral use is not standard.","evidence":"Limited"}]

Primary treatment for: Angina pectoris

Also treats: Coronary artery disease, Chronic stable angina

📋 Drug Information

Generic Name(s)Nitroglycerin
Brand NameAngispan - TR 2.5mg Capsule
ManufacturerCorona Remedies Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassCARDIAC
Action ClassNO Donors
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a dry place, away from direct sunlight. Keep in the original container, tightly closed.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine exactly as prescribed by your doctor, usually before activities that may trigger angina.
2
Do not use this medicine for immediate relief of an acute angina attack; use sublingual nitroglycerin for that purpose.
3
Avoid alcohol while taking this medicine as it can cause severe low blood pressure.
4
Rise slowly from sitting or lying positions to prevent dizziness and falls.
5
Inform your doctor if you experience persistent headaches or dizziness.
6
Do not stop this medicine abruptly without consulting your doctor, as it may worsen angina.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Chest pain triggered by exertion
This medicine is commonly prescribed for prevention of angina.
Likely Use
❌
Fever
This medicine is not a primary fever reducer.
Not Primary
❌
Acute angina attack
This medicine is not for immediate relief; sublingual nitroglycerin is used.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionNitroglycerin is rapidly absorbed from the gastrointestinal tract after oral administration, but it undergoes extensive first-pass metabolism in the liver, resulting in low systemic bioavailability. Sublingual and transdermal routes bypass this effect.
DistributionNitroglycerin is widely distributed throughout the body. It has a large volume of distribution and is not significantly bound to plasma proteins.
Protein BindingNot established from the available information.
MetabolismNitroglycerin is metabolized in the liver by glutathione-dependent organic nitrate reductase and also in the blood by enzymatic denitration. It is converted to dinitrate and mononitrate metabolites, which are less active.
Half-LifeThe elimination half-life of nitroglycerin is approximately 1-4 minutes.
ExcretionMetabolites of nitroglycerin are primarily excreted in the urine.
BioavailabilityOral bioavailability of nitroglycerin is low (approximately 10-20%) due to extensive first-pass metabolism.
Onset of ActionThe onset of action for oral nitroglycerin is typically within 30-60 minutes, but this can vary. For acute relief, sublingual forms are used with onset within 1-3 minutes.
Peak Plasma TimePeak plasma concentration after oral administration is reached in about 30-60 minutes.
Duration of ActionThe duration of action for oral nitroglycerin is approximately 4-6 hours, depending on the formulation and individual response.

How It Works

Nitroglycerin is a nitrate that is converted in the body to nitric oxide (NO), which activates guanylate cyclase. This leads to increased cyclic GMP (cGMP) levels, causing smooth muscle relaxation and vasodilation. The vasodilation predominantly affects veins, reducing preload and cardiac workload. At higher doses, it also dilates arteries, reducing afterload. This results in decreased myocardial oxygen demand and improved coronary blood flow, relieving angina.

Mechanism Steps

1
Conversion to nitric oxide: Nitroglycerin is metabolized to release nitric oxide (NO) in vascular smooth muscle cells.
2
Activation of guanylate cyclase: Nitric oxide binds to and activates the enzyme guanylate cyclase.
3
Increased cGMP: Activated guanylate cyclase converts GTP to cyclic GMP (cGMP), which acts as a second messenger.
4
Smooth muscle relaxation: Increased cGMP leads to relaxation of vascular smooth muscle by reducing intracellular calcium levels.
5
Vasodilation: Relaxation of smooth muscle causes dilation of veins and arteries, reducing preload and afterload.

💡 How to Take angiwell 6.4mg tablet

Strength: Nitroglycerin 6.4 mg immediate-release tablet

1Take this medicine orally with a glass of water.
2Swallow the tablet whole; do not crush, chew, or split unless instructed.
3Take it at the same times each day as prescribed.
4Take it before activities that may trigger angina, as directed by your doctor.
5Do not take more than the prescribed dose.

Dosage Information

Adult DosageThe usual adult dose of this medicine is 6.4 mg taken orally, typically two to three times daily, or as directed by your physician. The dose may be adjusted based on your condition and response to treatment. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may be more sensitive to the hypotensive effects of nitroglycerin. Start with a lower dose and monitor blood pressure closely. Dose must be individualized by a qualified clinician.
Renal ImpairmentNo specific dosage adjustment is provided in the labeling for renal impairment. Use with caution and monitor closely. Dose must be individualized by a qualified clinician.
Hepatic ImpairmentNo specific dosage adjustment is provided in the labeling for hepatic impairment. Use with caution and monitor closely. Dose must be individualized by a qualified clinician.
Maximum Daily DoseThe maximum daily dose should not exceed 19.2 mg (three 6.4 mg tablets) unless otherwise directed by a physician.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset.
Grapefruit
Avoid
May increase drug levels and risk of hypotension.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of angiwell 6.4mg tablet

✅ Common Side Effects

Headache (Common (5-10%))
Usually resolves with continued use. Consult doctor if severe or persistent.
Dizziness (Common (5-10%))
Rise slowly from sitting or lying positions. Avoid driving if affected.
Flushing (Common (5-10%))
Usually transient. Consult doctor if bothersome.
Lightheadedness (Common (5-10%))
Sit or lie down until it passes. Avoid sudden movements.
Hypotension (Common (5-10%))
Monitor blood pressure. Consult doctor if symptomatic.

🚨 Serious Side Effects

Severe hypotension (Rare (<0.1%))
Seek immediate medical attention if you experience fainting, severe dizziness, or blurred vision.
Syncope (Rare (<0.1%))
Lie down and elevate legs. Seek medical help if it occurs.
Methemoglobinemia (Very rare (<0.01%))
Seek emergency care if you experience bluish lips, skin, or nails, confusion, or shortness of breath.
Bradycardia (Rare (<0.1%))
Consult doctor if you experience unusually slow heartbeat or fainting.

⚠️ Rare Side Effects

Allergic reactions
Seek immediate medical attention if you notice rash, itching, swelling, or difficulty breathing.
Exfoliative dermatitis
Discontinue and consult doctor immediately if skin peeling occurs.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Sildenafil Major
Tadalafil Major
Vardenafil Major
Riociguat Major
Alcohol Moderate
Beta-blockers Moderate
Calcium channel blockers Moderate
Aspirin Minor
Heparin Minor
Grapefruit juice Moderate

🚨 Major Interactions

  • Sildenafil, tadalafil, vardenafil
  • Riociguat

⚡ Moderate Interactions

  • Alcohol
  • Antihypertensives (e.g., beta-blockers, calcium channel blockers)
  • Phosphodiesterase-5 inhibitors (other than those listed above)

🍷 Alcohol Interaction

Alcohol can intensify the blood pressure-lowering effects of nitroglycerin, leading to severe hypotension, dizziness, and fainting. It is advisable to avoid alcohol while taking this medicine.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Hypersensitivity to nitroglycerin or other nitrates","Severe hypotension (systolic BP

⚠️ Warnings & Precautions

["Use with caution in patients with low blood pressure or volume depletion.","May cause tolerance with prolonged use; nitrate-free intervals may be needed.","Avoid abrupt discontinuation as it may precipitate angina.","Use with caution in patients with glaucoma or increased intraocular pressure.","May aggravate angina in patients with hypertrophic cardiomyopathy.","Not for immediate relief of acute angina attacks; use sublingual forms for acute relief."]

🤱 Lactation Safety

It is not known whether nitroglycerin is excreted in human breast milk. Because many drugs are excreted in human milk, caution should be exercised when nitroglycerin is administered to a nursing woman. Consult your doctor before breastfeeding.

💊 Overdose Management

Overdose of nitroglycerin can cause severe hypotension, tachycardia, and methemoglobinemia. Treatment is supportive and symptomatic. If methemoglobinemia is present, methylene blue may be administered. Seek immediate medical attention.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.

Additional Safety Advice

General Safety

Always take this medicine exactly as prescribed. Do not crush, chew, or split the tablet unless instructed by your doctor. Avoid alcohol while taking this medicine as it can intensify blood pressure-lowering effects. Rise slowly from sitting or lying positions to prevent dizziness. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Do not use this medicine if you have taken sildenafil, tadalafil, or vardenafil within the last 24-48 hours. Keep this medicine out of reach of children.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients may be more sensitive to the blood pressure-lowering effects of this medicine. Start with a lower dose and monitor blood pressure closely. Falls due to dizziness are a concern; advise rising slowly.

🤰 Pregnancy Planning (TTC)

If you are planning to become pregnant, consult your doctor before taking this medicine. It is classified as Pregnancy Category C, meaning risk cannot be ruled out. Your doctor will weigh the benefits and risks.

🏥 Post-Surgery Considerations

Inform your surgeon and anesthesiologist that you are taking this medicine. It may interact with anesthetic agents and affect blood pressure during surgery. Your doctor may advise temporary discontinuation.

🦷 Dental Procedures

Inform your dentist that you are taking this medicine. It may cause dizziness or low blood pressure during dental procedures. Your dentist may take precautions.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to reduce the workload on your heart.
🥗
Engage in regular low-impact exercise like walking or swimming, as advised by your doctor.
😴
Avoid smoking and limit alcohol consumption.
💧
Manage stress through relaxation techniques like deep breathing or meditation.
🧘
Follow a heart-healthy diet low in saturated fats and sodium.
🌞
Get adequate sleep and rest.

🏋️ Exercise Considerations

Exercise can trigger angina in some patients. Take this medicine before exercise if prescribed. Avoid strenuous activities in extreme temperatures. Stop exercising immediately if you experience chest pain, dizziness, or shortness of breath.

🥗 Diet Recommendations

Include omega-3 rich foods like fish and flaxseeds.
Reduce intake of processed and fried foods.
Eat plenty of fruits and vegetables.
Limit sodium intake to control blood pressure.
Stay well hydrated.

💼 Impact on Daily Work & Life

This medicine may cause dizziness or lightheadedness, especially when standing up quickly. Avoid driving or operating heavy machinery if you experience these effects. It is important to inform your employer about your condition and medication, especially if your job involves physical exertion or operating machinery.

🛑 When to Stop This Medicine

Do not stop taking this medicine abruptly without consulting your doctor, as it may worsen angina. If you experience severe side effects or your condition changes, consult your doctor for dose adjustment or alternative treatment.

📅 Long-Term Use Effects

Long-term use of this medicine can lead to tolerance, reducing its effectiveness. To prevent this, doctors often recommend a nitrate-free interval of 10-12 hours each day. Regular monitoring of blood pressure and heart rate is advised. Long-term use may also cause headaches and dizziness. Consult your doctor for periodic evaluation.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Lifestyle modifications

Diet, exercise, and stress management can complement medication for angina.

Evidence: Well-established
Beta-blockers

Alternative class of medications for angina prevention.

Evidence: Well-established
Calcium channel blockers

Another class of medications for angina prevention.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

No specific vaccine interactions are known. However, consult your doctor before receiving any vaccine while on this medicine.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

When traveling, carry this medicine in its original packaging with a copy of your prescription. Store it at room temperature and protect it from direct sunlight. If crossing time zones, adjust your dosing schedule gradually as advised by your doctor. Keep it in your carry-on luggage to avoid loss. Check customs regulations for carrying prescription medicines.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 58-year-old man with chronic stable angina
He was prescribed this medicine to take before his morning walk, which often triggered chest pain. After starting the medicine, he noticed a significant reduction in angina episodes. He initially experienced headaches but they subsided after a week. He learned to take the tablet 30 minutes before his walk and to avoid alcohol.
💡 Lesson: Taking the medicine prophylactically before triggering activities can effectively prevent angina. Initial headaches are common but often transient.
👤 A 65-year-old woman with angina and hypertension
She was started on this medicine along with her antihypertensive drugs. She experienced dizziness upon standing, so her doctor adjusted her dose and advised her to rise slowly. She was also cautioned against using sildenafil, which she had occasionally taken. With these adjustments, she managed her angina well without significant side effects.
💡 Lesson: Close monitoring and dose adjustment are important, especially when combined with other blood pressure-lowering medications. Patients should be educated about drug interactions.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: When taken orally, this medicine typically starts working within 30-60 minutes. However, for acute relief, sublingual forms are used which work within 1-3 minutes.

Q: Can I take this medicine daily?

A: Yes, it can be taken daily as prescribed for prevention of angina. However, prolonged use may lead to tolerance, so your doctor may recommend a nitrate-free interval.

Q: What should I do if I miss a dose?

A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.

Q: Is it safe to take this medicine with other heart medications?

A: It can be taken with some heart medications, but interactions may occur. Always inform your doctor about all medications you are taking.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for angiwell 6.4mg tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can be taken for immediate relief of an ongoing angina attack.
    Fact: This medicine is for prevention of angina and is not intended for immediate relief. Sublingual nitroglycerin is used for acute attacks.
  • Myth: It is safe to take this medicine with erectile dysfunction drugs.
    Fact: Combining this medicine with sildenafil, tadalafil, or vardenafil can cause severe hypotension and is contraindicated.
  • Myth: This medicine can be taken indefinitely without any monitoring.
    Fact: Prolonged use can lead to tolerance. Regular monitoring and nitrate-free intervals may be necessary.

🔄 Alternative Options

Generic Alternatives

  • Nitroglycerin 6.4 mg tablet

Brand Alternatives

  • Angiwel 6.4 mg tablet

📊 Comparison with Similar Medicines

[{"medicine":"Nitroglycerin","class":"Nitrate","onset":"30-60 min (oral)","duration":"4-6 hours","common_use":"Prevention of angina"},{"medicine":"Isosorbide dinitrate","class":"Nitrate","onset":"30-60 min (oral)","duration":"4-6 hours","common_use":"Prevention of angina"},{"medicine":"Isosorbide mononitrate","class":"Nitrate","onset":"30-60 min (oral)","duration":"12-24 hours","common_use":"Prevention of angina"}]

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