Ancef SB 500 mg/250 mg Injection - Uses, Price, Side Effects
What is ancef sb 500 mg/250 mg injection used for?
Ancef SB 500 mg/250 mg Injection is a combination antibiotic containing Ceftriaxone and Sulbactam. It is used to treat various bacterial infections such as respiratory tract infections, urinary tract infections, skin infections, and septicemia. Ceftriaxone stops bacterial growth, while Sulbactam prevents bacterial resistance, enhancing the effectiveness of the medication.
- Generic Name: Ceftriaxone + Sulbactam
- Manufacturer: Shrinivas Gujarat Laboratories Pvt Ltd
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ ancef sb 500 mg/250 mg injection Uses & Benefits
Lower respiratory tract infections, urinary tract infections, skin and soft tissue infections, intra-abdominal infections, septicemia, meningitis, bone and joint infections
Off-label uses: Gonorrhea, Lyme disease, pelvic inflammatory disease
๐ Drug Information
| Generic Name(s) | Ceftriaxone + Sulbactam |
| Brand Name | Accuzon Plus 1.5gm Injection |
| Manufacturer | Shrinivas Gujarat Laboratories Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Cephalosporin + Beta-lactamase inhibitor |
| Route of Administration | Intravenous (IV) or Intramuscular (IM) |
| Storage | Store at 20-25ยฐC (68-77ยฐF); protect from light; reconstituted solution stable for 24 hours at room temperature or 3 days refrigerated |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Ceftriaxone inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs); Sulbactam irreversibly inhibits beta-lactamases, protecting ceftriaxone from degradation.
Mechanism Steps
๐ก How to Take ancef sb 500 mg/250 mg injection
Follow your doctor's prescription exactly.
Dosage Timeline
โ ๏ธ Side Effects of ancef sb 500 mg/250 mg injection
โ Common Side Effects
- Diarrhea
- Injection site reactions
- Rash
- Eosinophilia
๐จ Serious Side Effects
- Anaphylaxis
- Stevens-Johnson syndrome
- Clostridioides difficile colitis
- Hemolytic anemia
- Seizures
โ ๏ธ Rare Side Effects
- Pseudomembranous colitis
- Biliary sludge
- Interstitial nephritis
- Agranulocytosis
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | Increased bleeding risk |
| Alcohol | Moderate | Increased risk of liver toxicity |
| Probenecid | Moderate | Increased ceftriaxone levels |
๐จ Major Interactions
- Warfarin
- Alcohol (disulfiram-like reaction)
- Aminoglycosides (nephrotoxicity)
โก Moderate Interactions
- Probenecid
- Loop diuretics
- NSAIDs
โน๏ธ Minor Interactions
- Live vaccines
- BCG
๐ฝ๏ธ Food Interactions
None known
๐ท Alcohol Interaction
May cause disulfiram-like reaction (nausea, vomiting, headache)
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to cephalosporins or beta-lactam antibiotics; history of anaphylaxis to penicillins
๐ Monitoring Parameters
Renal function, hepatic function, CBC, signs of superinfection, bleeding tendencies
๐คฑ Lactation Safety
Excreted in breast milk in low amounts; generally considered compatible
๐ Overdose Management
Supportive care; hemodialysis may remove ceftriaxone but not sulbactam
โฐ Missed Dose
Administer as soon as remembered; if near next dose, skip missed dose; do not double dose