anasure cream - Lidocaine (3% w/w) + Calcium Dobesilate (0.25% w/w) medicine

Anasure Cream: Complete Medicine Guide

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🏭 Lifeline Remedies India Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 25, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Moderate for superficial venous disorders and hemorrhoids; limited for other uses.
Reviewed by
SaathiMed Expert Panel | Sep 25, 2026

When to Call Your Doctor IMMEDIATELY

  • Swelling of the face, lips, or throat
  • Difficulty breathing or wheezing
  • Severe dizziness or fainting
  • Irregular heartbeat or palpitations
  • Confusion or seizures
  • Severe skin blistering or peeling
  • Signs of infection at the application site (increased redness, warmth, pus)

If experiencing severe symptoms, call emergency services immediately.

What is anasure cream used for?

This medicine is a topical cream containing lidocaine 3% and calcium dobesilate 0.25%. It is used to relieve pain, swelling, and discomfort from superficial venous disorders and hemorrhoids. Apply a thin layer to the affected area 2-3 times daily as directed by your doctor.

  • Generic Name: Lidocaine + Calcium Dobesilate
  • Manufacturer: Lifeline Remedies India Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 anasure cream के बारे में (Hindi Summary)

उपयोग: यह दवा एक टॉपिकल क्रीम है जिसमें लिडोकेन 3% और कैल्शियम डोबेसिलेट 0.25% शामिल हैं। इसका उपयोग बाहरी शिरा विकारों, बवासीर और त्वचा की मामूली जलन से होने वाले दर्द, सूजन और जलन को कम करने के लिए किया जाता है। यह दवा प्रभावित क्षेत्र पर पतली परत में लगाई जाती है और यह दर्द को कम करने और सूजन को कम करने में मदद करती है।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में लगाने की जगह पर हल्की जलन, खुजली, लालिमा या सूखापन शामिल हैं। ये आमतौर पर हल्के होते हैं और कुछ समय में ठीक हो जाते हैं। गंभीर एलर्जी प्रतिक्रियाएं जैसे चेहरे, होंठ या गले में सूजन, सांस लेने में कठिनाई दुर्लभ हैं लेकिन तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को केवल प्रभावित त्वचा पर लगाएं। आंखों, मुंह, नाक और कान से संपर्क से बचें। लगाने से पहले और बाद में हाथ धोएं। बड़े घावों या संक्रमित त्वचा पर न लगाएं। गर्भावस्था या स्तनपान के दौरान डॉक्टर से सलाह लें। बच्चों की पहुंच से दूर रखें। 7 दिनों से अधिक उपयोग न करें या डॉक्टर की सलाह के बिना न रोकें।

💡 Did You Know? The Indian pharmaceutical market is expected to reach $130 billion by 2030.

💊 anasure cream Uses & Benefits

[{"condition":"Superficial venous disorders","description":"Relieves pain, heaviness, and inflammation" class="semantic-link" title="Medicines for swelling">swelling associated with varicose veins and chronic venous insufficiency.","evidence":"Moderate"},{"condition":"Hemorrhoids","description":"Provides local anesthesia and reduces inflammation and bleeding in external hemorrhoids.","evidence":"Moderate"},{"condition":"Minor skin irritations","description":"Soothes pain and itching from insect bites, minor burns, or abrasions.","evidence":"Limited"},{"condition":"Post-surgical pain","description":"May be used for local pain relief after minor surgical procedures on the skin.","evidence":"Limited"}]

Off-label uses: [{"condition":"Diabetic neuropathy pain","description":"Sometimes applied topically for localized neuropathic pain, but evidence is limited.","evidence":"Limited"},{"condition":"Anal fissure pain","description":"May provide temporary relief of pain associated with anal fissures.","evidence":"Limited"}]

Primary treatment for: Superficial venous disorders

Also treats: Hemorrhoids, Chronic venous insufficiency, Minor skin irritations

📋 Drug Information

Generic Name(s)Lidocaine + Calcium Dobesilate
Brand NameAnasure Cream
ManufacturerLifeline Remedies India Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassCARDIAC
Action ClassLocal anesthetic + Capillary stabilizer
Route of AdministrationTopical
StorageStore at room temperature (15-30°C) in a dry place. Protect from direct sunlight and heat. Do not freeze.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Apply this medicine only to the affected area and avoid healthy skin.
2
Wash your hands before and after application to prevent accidental exposure to eyes or mouth.
3
Do not use airtight dressings over the treated area unless specifically instructed.
4
If you are using other topical products, consult your doctor before applying them on the same area.
5
Stop using this medicine and consult a doctor if symptoms do not improve within 7 days.
6
Keep a record of your application times to avoid missing or doubling doses.
7
Inform your doctor if you have liver or kidney problems before using this medicine.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Painful external hemorrhoids
This medicine is commonly prescribed for this.
Likely Use
✅
Leg swelling and heaviness
This medicine may help with venous insufficiency symptoms.
Likely Use
❌
Fever
This medicine is not a fever reducer.
Not Primary
❌
Headache
This medicine is not indicated for headache.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionLidocaine is absorbed through intact skin, but systemic absorption depends on the surface area, duration of application, and skin condition. Calcium dobesilate absorption through intact skin is limited. Not established from the available information for this specific topical formulation.
DistributionNot established from the available information for this specific topical formulation.
Protein BindingLidocaine is approximately 65% bound to plasma proteins. Protein binding of calcium dobesilate is not established from the available information.
MetabolismLidocaine is metabolized in the liver primarily by CYP3A4 and CYP1A2 enzymes. Calcium dobesilate is minimally metabolized and is excreted largely unchanged.
Half-LifeThe elimination half-life of lidocaine is approximately 1.5 to 2 hours. The elimination half-life of calcium dobesilate is approximately 5 to 6 hours.
ExcretionLidocaine metabolites are excreted mainly in urine. Calcium dobesilate is excreted primarily unchanged in urine.
BioavailabilityNot established from the available information for this specific topical formulation.
Onset of ActionLocal anesthetic effect of lidocaine begins within 3 to 5 minutes after application. Venotonic effects of calcium dobesilate may take several hours to days to become noticeable.
Peak Plasma TimeNot established from the available information for this specific topical formulation.
Duration of ActionLocal anesthetic effect of lidocaine lasts approximately 30 to 60 minutes. Symptomatic relief from calcium dobesilate may last several hours after application.

How It Works

This medicine combines two active ingredients with complementary actions. Lidocaine reversibly blocks sodium channels in nerve cell membranes, preventing the generation and conduction of nerve impulses, which results in local numbness and pain relief. Calcium dobesilate reduces capillary permeability and fragility, improves lymphatic drainage, and decreases blood viscosity, thereby reducing edema and inflammation. Together, they provide symptomatic relief from pain and swelling in superficial venous conditions.

Mechanism Steps

1
Sodium channel blockade by lidocaine: Lidocaine binds to voltage-gated sodium channels on sensory nerve endings, preventing depolarization and blocking pain signal transmission.
2
Capillary stabilization by calcium dobesilate: Calcium dobesilate reduces capillary permeability and fragility, decreasing fluid leakage into surrounding tissues and reducing edema.
3
Anti-inflammatory effect: Calcium dobesilate inhibits the release of inflammatory mediators and reduces blood viscosity, leading to less swelling and pain.
4
Symptom relief: The combined local anesthetic and venotonic actions result in rapid relief of pain, burning, and heaviness in the affected area.

💡 How to Take anasure cream

Strength: Cream containing lidocaine 3% w/w and calcium dobesilate 0.25% w/w.

1Wash your hands thoroughly before and after applying the cream.
2Clean and dry the affected area gently.
3Apply a thin layer of the cream to the affected area.
4Gently massage the cream into the skin until it is absorbed.
5Do not cover the area with a tight bandage unless instructed by your doctor.
6Avoid contact with eyes, mouth, and other mucous membranes.
7Use only as directed by your doctor.

Dosage Information

Adult DosageApply a thin layer of this medicine to the affected area 2 to 3 times daily, or as directed by your doctor. The exact frequency and duration depend on the condition being treated and your response to therapy. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the recommended dose or duration without medical advice.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may be more sensitive to the effects of lidocaine. Use with caution and follow the doctor's instructions. No specific dose adjustment is established for topical use, but individualization is advised.
Renal ImpairmentNo specific dose adjustment is established for topical use. Use with caution in patients with severe renal impairment due to limited data.
Hepatic ImpairmentNo specific dose adjustment is established for topical use. Use with caution in patients with severe hepatic impairment due to limited data.
Maximum Daily DoseNot established from the available information. Do not exceed the frequency recommended by your doctor.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Apply the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not apply a double dose to catch up.

⚠️ Side Effects of anasure cream

✅ Common Side Effects

Application site burning (Common (1-10%))
Usually resolves on its own. If persistent or severe, stop use and consult a doctor.
Application site itching (Common (1-10%))
Avoid scratching. If itching persists, consult a doctor.
Redness or rash (Uncommon (0.1-1%))
Discontinue use and consult a doctor if rash develops.

🚨 Serious Side Effects

Severe allergic reaction (anaphylaxis) (Rare (<0.1%))
Seek immediate medical attention if you experience swelling of face, lips, throat, difficulty breathing, or severe dizziness.
Systemic lidocaine toxicity (Rare (<0.1%))
Seek immediate medical attention if you experience confusion, drowsiness, irregular heartbeat, or seizures.
Severe skin reactions (e.g., blistering, peeling) (Rare (<0.1%))
Stop using this medicine and seek immediate medical attention.

⚠️ Rare Side Effects

Methemoglobinemia
Seek immediate medical attention if you experience bluish discoloration of lips or skin, shortness of breath, or confusion.
Contact dermatitis
Discontinue use and consult a doctor for appropriate treatment.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Class I antiarrhythmics Major
Cimetidine Major
Beta-blockers Moderate
Other topical anesthetics Moderate
Warfarin Minor

🚨 Major Interactions

  • Class I antiarrhythmics (e.g., tocainide, mexiletine)
  • Cimetidine

⚡ Moderate Interactions

  • Beta-blockers (e.g., propranolol)
  • Other topical anesthetics

🍷 Alcohol Interaction

No specific interaction between alcohol and this topical medicine has been established. However, alcohol may worsen underlying venous conditions and should be consumed in moderation.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known hypersensitivity to lidocaine, calcium dobesilate, or any component of the cream","Application to large areas of broken or infected skin","Use in the eyes, ears, or mucous membranes","Severe hepatic or renal impairment (relative contraindication due to limited data)"]

⚠️ Warnings & Precautions

["For external use only. Do not ingest.","Avoid contact with eyes and mucous membranes.","Do not apply to large areas or use for prolonged periods without medical advice.","Use with caution in patients with severe liver or kidney disease.","Use with caution in patients with cardiac conduction disorders.","Do not use if the packaging is damaged or the cream has changed color.","Keep out of reach of children."]

🤱 Lactation Safety

It is not known whether calcium dobesilate is excreted in human breast milk. Lidocaine passes into breast milk in small amounts. Consult your doctor before using this medicine while breastfeeding. Avoid applying to the breast area to prevent infant exposure.

💊 Overdose Management

Overdose from topical application is unlikely unless large amounts are ingested or applied to large areas of broken skin. If accidental ingestion occurs, seek immediate medical attention. Symptoms of lidocaine toxicity include dizziness, drowsiness, confusion, seizures, and irregular heartbeat. Treatment is supportive and symptomatic. Contact a poison control center or emergency services immediately.

⏰ Missed Dose

If you miss a dose, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not apply a double dose to make up for a missed one.

Additional Safety Advice

General Safety

Apply this medicine only to the affected area and avoid contact with eyes, ears, nose, mouth, and other mucous membranes. Wash your hands thoroughly before and after application unless your hands are the treated area. Do not cover the treated area with airtight dressings unless instructed by a doctor. Do not use this medicine on deep wounds, infected skin, or large areas of broken skin. Avoid using other topical products on the same area without medical advice. If you are pregnant, planning pregnancy, or breastfeeding, consult your doctor before using this medicine. Keep this medicine out of reach of children. Do not exceed the recommended frequency or duration of use. If symptoms persist or worsen after 7 days, stop using this medicine and seek medical advice.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients may be more sensitive to the effects of lidocaine. Use with caution and follow your doctor's instructions. Monitor for signs of dizziness or drowsiness. No specific dose adjustment is established for topical use, but individualization is advised.

🤰 Pregnancy Planning (TTC)

If you are planning pregnancy, consult your doctor before using this medicine. Lidocaine is generally considered safe for topical use during pregnancy, but calcium dobesilate should be used with caution due to limited data.

🏥 Post-Surgery Considerations

This medicine may be used after minor surgical procedures for local pain relief, but only if advised by your surgeon. Do not apply to surgical wounds without medical advice.

🦷 Dental Procedures

This medicine is not intended for use in the mouth. For dental procedures, inform your dentist about any medications you are using, including this cream.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to reduce pressure on veins.
🥗
Avoid prolonged standing or sitting; take frequent breaks to move around.
😴
Elevate your legs when sitting or lying down to improve circulation.
💧
Wear compression stockings if advised by your doctor.
🧘
Stay physically active with low-impact exercises like walking or swimming.
🌞
Avoid tight clothing that restricts blood flow.
🚭
Stay well hydrated and eat a high-fiber diet to prevent constipation.

🏋️ Exercise Considerations

Regular exercise is beneficial for venous health, but avoid strenuous activities that may increase pain or swelling in the affected area. If you have hemorrhoids, avoid heavy lifting and straining. Consult your doctor before starting any new exercise routine.

🥗 Diet Recommendations

Include fiber-rich foods like fruits, vegetables, and whole grains to prevent constipation.
Reduce salt intake to minimize fluid retention and swelling.
Stay well hydrated by drinking plenty of water.
Limit processed and fried foods that can worsen inflammation.
Include anti-inflammatory foods like omega-3 fatty acids, berries, and leafy greens.

💼 Impact on Daily Work & Life

This medicine is applied topically and is unlikely to affect your ability to work or drive. However, if you experience dizziness or drowsiness after application, avoid driving or operating heavy machinery until you feel alert. For hemorrhoids, sitting for long periods may be uncomfortable; take breaks and use a cushion if needed.

🛑 When to Stop This Medicine

Stop using this medicine and consult your doctor if your symptoms do not improve within 7 days, if they worsen, or if you experience any severe side effects. Do not stop prescribed treatment without consulting your doctor.

📅 Long-Term Use Effects

Long-term use of this medicine should be under medical supervision. Prolonged application over large areas may increase the risk of systemic lidocaine absorption, leading to toxicity. Calcium dobesilate is generally well tolerated, but long-term safety data are limited. Regular follow-up with your doctor is recommended to assess the need for continued use.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Compression therapy

Wearing compression stockings can help reduce swelling and pain in venous disorders.

Evidence: Well-established
Sitz baths

Warm sitz baths can soothe hemorrhoid pain and promote healing.

Evidence: Moderate
Lifestyle modifications

Diet, exercise, and weight management can improve venous health.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

No specific interaction between this medicine and vaccines has been established. Continue routine vaccinations as scheduled.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of your prescription. Store it in a cool, dry place away from direct sunlight. If traveling to a different time zone, continue your regular application schedule as closely as possible. For air travel, keep it in your carry-on bag if you need it during the flight. Check customs regulations for topical medications before traveling internationally.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 50-year-old woman with painful external hemorrhoids
She was prescribed this medicine to apply twice daily. After 3 days, she noticed significant reduction in pain and swelling. She emphasized that washing the area gently before application and avoiding straining during bowel movements helped.
💡 Lesson: Consistent application and lifestyle modifications improve outcomes for hemorrhoid symptoms.
👤 A 60-year-old man with chronic venous insufficiency in the legs
He used this medicine on his lower legs as directed. He experienced mild burning on the first few applications, which subsided. After 2 weeks, the heaviness and swelling in his legs were noticeably better. He also started wearing compression stockings as advised.
💡 Lesson: Combining this medicine with compression therapy and leg elevation can enhance relief from venous symptoms.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: The numbing effect of lidocaine starts within 3-5 minutes. Relief from swelling and heaviness may take several hours to days of regular use.

Q: Can I use this medicine on open wounds?

A: No, do not apply to open wounds, large areas of broken skin, or infected areas unless specifically instructed by your doctor.

Q: Is this medicine safe for children?

A: Pediatric dosing is not established. Consult a pediatrician before using this medicine on a child.

Q: Can I use this medicine while breastfeeding?

A: Consult your doctor before use. Avoid applying to the breast area to prevent infant exposure.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I use this medicine on my face?
  • How long can I use this medicine?
  • Is it safe to use during pregnancy?
  • Can I use it with other creams?
  • What if I miss a dose?
  • Does it interact with my other medicines?

🔄 Substitutes for anasure cream

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can cure varicose veins permanently.
    Fact: This medicine provides symptomatic relief but does not cure the underlying condition. Lifestyle changes and other treatments may be needed.
  • Myth: More cream means faster relief.
    Fact: Applying more than the recommended amount does not speed up relief and may increase the risk of side effects.
  • Myth: This medicine is safe to use on any skin wound.
    Fact: It should not be applied to large areas of broken or infected skin unless specifically advised by a doctor.

🔄 Alternative Options

Generic Alternatives

  • Lidocaine 3% + Calcium Dobesilate 0.25% cream (generic versions may be available)

📊 Comparison with Similar Medicines

[{"medicine":"This medicine","active_ingredients":"Lidocaine 3% + Calcium dobesilate 0.25%","primary_use":"Superficial venous disorders, hemorrhoids","route":"Topical"},{"medicine":"Lidocaine 2% gel","active_ingredients":"Lidocaine 2%","primary_use":"Local anesthesia","route":"Topical"},{"medicine":"Calcium dobesilate 0.25% cream","active_ingredients":"Calcium dobesilate 0.25%","primary_use":"Venous disorders","route":"Topical"}]

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