amzocef s 500mg/500mg injection - Cefoperazone (500mg) + Sulbactam (500mg) medicine

Amzocef S 500mg/500mg Injection - Uses, Price, Side Effects

4.4 (14 reviews)

Cefoperazone (500mg) Sulbactam (500mg)

🏭 Amzor Healthcare 📦 Varies by brand 💊 Allopathy 📅 Updated: Aug 22, 2026

⚠️ Hepatotoxicity Risk 📋 Prescription Required 💊 Generic Available

Medically Reviewed

SaathiMed Expert Panel | Aug 22, 2026

What is amzocef s 500mg/500mg injection used for?

Amzocef S 500mg/500mg Injection contains Cefoperazone (a cephalosporin antibiotic) and Sulbactam (a beta-lactamase inhibitor). It is used to treat various bacterial infections such as respiratory tract, urinary tract, skin, and intra-abdominal infections. Cefoperazone kills bacteria by inhibiting cell wall synthesis, while Sulbactam prevents bacterial resistance. It is administered intravenously or intramuscularly under medical supervision.

Generic Name: Cefoperazone + Sulbactam
Manufacturer: Amzor Healthcare
Form: Allopathy
Pregnancy Category: A
Prescription Required: Yes

💡 Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

💊 amzocef s 500mg/500mg injection Uses & Benefits

Treatment of infections caused by susceptible organisms: respiratory tract infections, intra-abdominal infections, skin and soft tissue infections, septicemia, urinary tract infections, gynecological infections, and perioperative prophylaxis.

Off-label uses: Bone and joint infections, Meningitis (when other agents fail), Febrile neutropenia (in combination)

📋 Drug Information

Generic Name(s)	Cefoperazone + Sulbactam
Brand Name	Acuzone S 1000mg/500mg Injection
Manufacturer	Amzor Healthcare
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	ANTI INFECTIVES
Action Class	Cephalosporin + Beta-lactamase inhibitor
Route of Administration	Intravenous (IV) or intramuscular (IM)
Storage	Store at 20-25°C (68-77°F); protect from light; reconstituted solution stable for 24 hours at room temperature and 5 days under refrigeration.
Shelf Life	As per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionIntravenous administration results in complete bioavailability; intramuscular absorption is rapid and complete.

DistributionWidely distributed in body tissues and fluids including bile, sputum, pleural fluid, and CSF (inflamed meninges).

Protein BindingCefoperazone: 70-93%; Sulbactam: 38%

MetabolismCefoperazone: Not significantly metabolized; Sulbactam: Partially metabolized.

Half-LifeCefoperazone: 1.7-2 hours; Sulbactam: 1-1.3 hours

ExcretionCefoperazone: Primarily biliary (70-75%) and renal (20-30%); Sulbactam: Primarily renal (80%)

Bioavailability100% (IV); IM absorption is complete.

Onset of ActionRapid (within minutes after IV administration)

Peak Plasma TimeImmediately after IV infusion; 1-2 hours after IM injection

Duration of ActionApproximately 12 hours

How It Works

Cefoperazone inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs); Sulbactam irreversibly inhibits beta-lactamases, protecting cefoperazone from degradation.

Mechanism Steps

1Cefoperazone binds to penicillin-binding proteins (PBPs) on bacterial cell wall.

2Inhibition of transpeptidase and other PBPs disrupts peptidoglycan cross-linking.

3Autolytic enzymes are activated, leading to cell lysis and death.

💡 How to Take amzocef s 500mg/500mg injection

Follow your doctor's prescription exactly.

Dosage Timeline

🌅 Morning ✅ ☀️ Afternoon ❌ 🌆 Evening ✅ 🌙 Night ❌

⚠️ Side Effects of amzocef s 500mg/500mg injection

✅ Common Side Effects

Diarrhea
Nausea
Vomiting
Rash
Injection site pain
Phlebitis
Elevated liver enzymes

🚨 Serious Side Effects

Severe allergic reactions (anaphylaxis)
Stevens-Johnson syndrome
Clostridioides difficile-associated diarrhea
Seizures
Bleeding tendencies (hypoprothrombinemia)

⚠️ Rare Side Effects

Agranulocytosis
Hemolytic anemia
Interstitial nephritis
Pseudomembranous colitis
Serum sickness-like reactions

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug	Severity	Effect
Warfarin	Major	Increased bleeding risk
Alcohol	Moderate	Disulfiram-like reaction
Probenecid	Moderate	Increased cefoperazone levels

🚨 Major Interactions

Alcohol
Warfarin
Heparin
Methotrexate
Probenecid

⚡ Moderate Interactions

Aminoglycosides
Loop diuretics
NSAIDs
Oral contraceptives

ℹ️ Minor Interactions

Antacids
Iron supplements
Zinc supplements

🍽️ Food Interactions

No significant food interactions; avoid alcohol during treatment and for 72 hours after last dose.

🍷 Alcohol Interaction

Disulfiram-like reaction (flushing, headache, nausea, vomiting, tachycardia) can occur if alcohol is consumed within 72 hours of administration.

🛡️ Safety & Warnings

Liver

Moderate

Kidney

Low

Heart

Low

Pregnancy

Category A

🚫 Contraindications

Hypersensitivity to cephalosporins, penicillins, or beta-lactamase inhibitors; severe renal impairment (CrCl <15 mL/min) without dose adjustment.

📊 Monitoring Parameters

Renal function, hepatic function, CBC with differential, prothrombin time (especially in patients at risk of bleeding), signs of superinfection.

🤱 Lactation Safety

Cefoperazone and sulbactam are excreted in breast milk in low concentrations; use with caution.

💊 Overdose Management

Supportive care; hemodialysis may enhance elimination; monitor for seizures and hypersensitivity reactions.

⏰ Missed Dose

Administer as soon as remembered; if near next dose, skip missed dose and resume regular schedule; do not double dose.

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 22, 2026

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⭐ User Reviews

Trusted Reviewer Jul 10, 2026

This medicine was effective for me. I followed the doctor's advice.

Certified Buyer Jul 10, 2026

Effective and reliable. Worked as expected.