amoline h 5mg/12.5mg tablet - Uses, Price, Side Effects & Substitutes
What is amoline h 5mg/12.5mg tablet used for?
Amlong-H Tablet (Amlodipine + Hydrochlorothiazide) is used to treat CARDIAC. It contains Amlodipine (5mg) + Hydrochlorothiazide (12.5mg), which Amlodipine inhibits calcium influx across cell membranes, causing vasodilation; . Always consult your doctor before use. Take as prescribed.
- Generic Name: Amlodipine + Hydrochlorothiazide
- Manufacturer: Zeelab Pharmacy Pvt Ltd
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ amoline h 5mg/12.5mg tablet Uses & Benefits
Hypertension (alone or in combination); not for initial therapy
Off-label uses: Chronic stable angina (amlodipine alone); heart failure (amlodipine alone)
๐ Drug Information
| Generic Name(s) | Amlodipine + Hydrochlorothiazide |
| Brand Name | Amlong-H Tablet |
| Manufacturer | Zeelab Pharmacy Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | Calcium channel blocker + Thiazide diuretic |
| Route of Administration | Oral |
| Storage | Store at 20-25ยฐC (68-77ยฐF); protect from light and moisture |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Amlodipine inhibits calcium influx across cell membranes, causing vasodilation; Hydrochlorothiazide inhibits sodium reabsorption in distal tubules, reducing plasma volume
Mechanism Steps
๐ก How to Take amoline h 5mg/12.5mg tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of amoline h 5mg/12.5mg tablet
โ Common Side Effects
- Edema (ankle swelling)
- Dizziness
- Headache
- Fatigue
- Nausea
- Flushing
- Palpitations
- Hypokalemia
- Hyperuricemia
- Increased urination
๐จ Serious Side Effects
- Severe hypotension
- Syncope
- Arrhythmias
- Acute renal failure
- Pancreatitis
- Stevens-Johnson syndrome
- Toxic epidermal necrolysis
- Angioedema
โ ๏ธ Rare Side Effects
- Hepatotoxicity
- Leukopenia
- Thrombocytopenia
- Anaphylaxis
- Photosensitivity
- Acute angle-closure glaucoma
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| CYP3A4 inhibitors (e.g., ketoconazole) | Major | Increased amlodipine levels, risk of toxicity |
| CYP3A4 inducers (e.g., rifampin) | Major | Decreased amlodipine efficacy |
| Lithium | Major | Increased lithium toxicity risk |
| Digoxin | Major | Increased digoxin levels, risk of toxicity |
| NSAIDs | Moderate | Reduced antihypertensive effect, increased renal impairment risk |
| Corticosteroids | Moderate | Hypokalemia, reduced diuretic effect |
| Cholestyramine | Moderate | Reduced hydrochlorothiazide absorption |
| Alcohol | Minor | Increased orthostatic hypotension |
๐จ Major Interactions
- CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, ritonavir)
- CYP3A4 inducers (e.g., rifampin, carbamazepine)
- Lithium
- Digoxin
- Other antihypertensives (additive effect)
โก Moderate Interactions
- NSAIDs
- Corticosteroids
- Amphotericin B
- Cholestyramine
- Colestipol
โน๏ธ Minor Interactions
- Calcium supplements
- Vitamin D
- Antacids
๐ฝ๏ธ Food Interactions
Grapefruit juice may increase amlodipine levels; avoid high-sodium foods
๐ท Alcohol Interaction
May potentiate orthostatic hypotension; avoid excessive alcohol
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to amlodipine, hydrochlorothiazide, or sulfonamides; anuria; severe renal impairment; hypercalcemia; symptomatic hypotension; cardiogenic shock
๐ Monitoring Parameters
Blood pressure, heart rate, serum electrolytes (K+, Na+, Ca2+), renal function, hepatic function, blood glucose, uric acid
๐คฑ Lactation Safety
Amlodipine excreted in milk; hydrochlorothiazide may suppress lactation; avoid or use with caution
๐ Overdose Management
Gastric lavage, activated charcoal; monitor BP, ECG; treat hypotension with fluids and vasopressors; correct electrolyte imbalances
โฐ Missed Dose
Take as soon as remembered; if close to next dose, skip missed dose; do not double dose