D Fresh MR 250mg/50mg Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Unusual bleeding or bruising
- Severe skin rash with blisters or peeling
If experiencing severe symptoms, call emergency services immediately.
What is amol mr 250mg/50mg/325mg tablet used for?
This medicine is a combination of Chlorzoxazone 250 mg and Diclofenac 50 mg used for short-term relief of acute musculoskeletal pain and muscle spasm. It works by relaxing muscles and reducing inflammation. Take it with food, avoid alcohol, and do not use it for more than 7-10 days without medical advice.
- Generic Name: Chlorzoxazone + Diclofenac
- Manufacturer: Aman Healthcare
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 amol mr 250mg/50mg/325mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा क्लोरज़ोक्साज़ोन 250 मिलीग्राम और डाइक्लोफेनाक 50 मिलीग्राम का संयोजन है। इसका उपयोग मांसपेशियों में ऐंठन और सूजन के कारण होने वाले दर्द के अल्पकालिक उपचार के लिए किया जाता है, जैसे कमर दर्द, गर्दन दर्द, मोच और खिंचाव। यह मांसपेशियों को आराम देकर और सूजन को कम करके दर्द से राहत देती है। इसे भोजन के साथ लें और शराब से बचें। बिना डॉक्टर की सलाह के 7-10 दिन से अधिक न लें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में जी मिचलाना, पेट दर्द, सीने में जलन, दस्त, नींद आना, चक्कर आना और सिरदर्द शामिल हैं। गंभीर दुष्प्रभावों में पेट में अल्सर या रक्तस्राव, गुर्दे की समस्या, यकृत की क्षति, और दिल से जुड़ी समस्याएं हो सकती हैं। यदि काला या खूनी मल, खून की उल्टी, तेज पेट दर्द, आंखों या त्वचा का पीलापन, पेशाब में कमी, या सांस लेने में कठिनाई हो तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें, भोजन या दूध के साथ लेना बेहतर है। शराब बिल्कुल न लें। अगर नींद या चक्कर आएं तो वाहन न चलाएं। पेट अल्सर, दिल, गुर्दे या यकृत की बीमारी, दमा या खून से जुड़ी समस्या हो तो डॉक्टर को बताएं। बिना सलाह के अन्य दर्द निवारक दवाएं न लें। सबसे कम प्रभावी खुराक सबसे कम समय के लिए लें। गर्भावस्था या स्तनपान के दौरान डॉक्टर से सलाह लें।
💊 amol mr 250mg/50mg/325mg tablet Uses & Benefits
[{"condition":"Acute musculoskeletal pain with muscle spasm","description":"Relieves pain and reduces muscle spasm in conditions such as acute low back pain, neck pain, and myofascial pain syndrome.","evidence":"Well-established"},{"condition":"Post-traumatic pain and inflammation" class="semantic-link" title="Medicines for swelling">swelling","description":"Helps reduce pain and inflammation after sprains, strains, and soft tissue injuries.","evidence":"Well-established"},{"condition":"Post-operative musculoskeletal pain","description":"May be used short-term after orthopedic procedures to manage pain and muscle spasm.","evidence":"Moderate"},{"condition":"Tension-type headache with neck muscle spasm","description":"Can provide relief when headache is associated with significant neck muscle tightness.","evidence":"Limited"}]
Off-label uses: [{"condition":"Fibromyalgia pain flare","description":"Sometimes prescribed off-label for short-term relief of muscle pain in fibromyalgia, though evidence is limited.","evidence":"Limited"},{"condition":"Temporomandibular joint disorder","description":"May be used off-label for jaw muscle spasm and pain, but not a standard first-line treatment.","evidence":"Limited"}]
Primary treatment for: Acute musculoskeletal pain with muscle spasm
Also treats: Low back pain, Neck pain, Sprains and strains, Myofascial pain syndrome, Post-operative musculoskeletal pain
📋 Drug Information
| Generic Name(s) | Chlorzoxazone + Diclofenac |
| Brand Name | Ache X Tablet |
| Manufacturer | Aman Healthcare |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | Muscle Relaxant + NSAID |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C. Protect from light and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture, or as printed on the packaging. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with different mechanisms. Chlorzoxazone is a centrally acting skeletal muscle relaxant that primarily inhibits polysynaptic reflexes in the spinal cord and subcortical areas of the brain, reducing excessive muscle tone without directly affecting the neuromuscular junction. Diclofenac is a nonsteroidal anti-inflammatory drug that reversibly inhibits cyclooxygenase enzymes, leading to decreased synthesis of prostaglandins, which are mediators of pain, inflammation, and fever. The combination targets both the muscle spasm component and the inflammatory pain component of musculoskeletal conditions.
Mechanism Steps
💡 How to Take amol mr 250mg/50mg/325mg tablet
Strength: Tablet containing Chlorzoxazone 250 mg and Diclofenac 50 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet taken orally two to three times a day, preferably with food. The exact dose and duration depend on the condition being treated, its severity, and your response to therapy. Do not exceed the recommended dose. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. This medicine is intended for short-term use only. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients above 65 years are at higher risk of gastrointestinal bleeding, kidney impairment, and cardiovascular events. Use the lowest effective dose for the shortest duration. Monitor kidney function and blood pressure closely. Consult a doctor before use. |
| Renal Impairment | Use with caution in patients with kidney disease. Dose reduction or avoidance may be necessary. Consult a doctor for individualized dosing. |
| Hepatic Impairment | Avoid use in patients with severe liver disease. Use with caution in mild to moderate liver impairment. Consult a doctor for individualized dosing. |
| Maximum Daily Dose | The maximum recommended daily dose is not established from available information. Do not exceed the dose prescribed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of amol mr 250mg/50mg/325mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Aspirin | Major | |
| Methotrexate | Major | |
| Lithium | Major | |
| Cyclosporine | Major | |
| ACE inhibitors | Moderate | |
| Diuretics | Moderate | |
| Corticosteroids | Moderate | |
| SSRIs | Moderate | |
| Fluconazole | Moderate |
🚨 Major Interactions
- Warfarin and other anticoagulants
- Other NSAIDs including aspirin
- Methotrexate
- Lithium
- Cyclosporine
⚡ Moderate Interactions
- ACE inhibitors and angiotensin receptor blockers
- Diuretics
- Corticosteroids
- Selective serotonin reuptake inhibitors (SSRIs)
- CYP2C9 inhibitors such as fluconazole
🍷 Alcohol Interaction
Alcohol should be completely avoided while taking this medicine. Alcohol increases the risk of stomach bleeding, ulcers, and liver damage when combined with diclofenac. It also adds to the drowsiness and dizziness caused by chlorzoxazone, increasing the risk of falls and accidents.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Active peptic ulcer or gastrointestinal bleeding","Severe heart failure","Severe kidney disease","Severe liver disease","History of asthma, urticaria, or allergic reaction to aspirin or other NSAIDs","Coronary artery bypass graft surgery (peri-operative period)","Pregnancy (third trimester)","Known hypersensitivity to chlorzoxazone or diclofenac"]
⚠️ Warnings & Precautions
["Take with food to reduce stomach upset.","Avoid alcohol completely.","Do not drive or operate machinery if drowsy.","Use with caution in elderly patients due to increased risk of side effects.","Do not use for more than 7-10 days without medical advice.","Inform your doctor if you have a history of stomach ulcers, heart disease, kidney or liver problems.","Do not take other NSAIDs or blood thinners without consulting your doctor.","Stop the medicine and seek medical help if you notice signs of bleeding or allergic reaction."]
🤱 Lactation Safety
Diclofenac is excreted in breast milk in small amounts. Chlorzoxazone safety during breastfeeding is not well established. Consult your doctor before using this medicine while breastfeeding.
💊 Overdose Management
Overdose of this medicine may cause severe nausea, vomiting, stomach pain, drowsiness, dizziness, and in severe cases, gastrointestinal bleeding, liver damage, or kidney failure. Seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote. Activated charcoal may be considered if the patient presents early. Monitor vital signs, liver and kidney function, and manage complications as they arise.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor, preferably with food or milk to reduce stomach irritation. Do not crush, chew, or break the tablet unless your doctor advises otherwise. Avoid alcohol completely while taking this medicine because it increases the risk of stomach bleeding and liver problems. Do not drive or operate heavy machinery if you feel drowsy or dizzy. Inform your doctor if you have a history of stomach ulcers, heart disease, kidney or liver problems, asthma, or bleeding disorders. Do not take other pain relievers, blood thinners, or steroids without consulting your doctor. Use the lowest effective dose for the shortest possible time. If you are pregnant, planning pregnancy, or breastfeeding, talk to your doctor before using this medicine. Keep all follow-up appointments and report any unusual symptoms immediately.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients above 65 years are at higher risk of gastrointestinal bleeding, kidney impairment, and cardiovascular events. Use the lowest effective dose for the shortest duration. Monitor kidney function, blood pressure, and signs of bleeding. Avoid if possible in frail elderly patients.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before taking this medicine. Diclofenac may affect ovulation and is generally avoided during pregnancy, especially in the third trimester. Chlorzoxazone safety in pregnancy is not well established.
🏥 Post-Surgery Considerations
This medicine may be used short-term after surgery for pain and muscle spasm, but it can increase bleeding risk and impair wound healing. Consult your surgeon before using it. It is contraindicated in the peri-operative period of coronary artery bypass graft surgery.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine before any dental procedure, as it may increase bleeding risk. Your dentist may advise stopping it temporarily or taking precautions.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise or heavy lifting while taking this medicine, especially if you feel drowsy or dizzy. Gentle stretching and range-of-motion exercises may be beneficial, but consult your doctor or physiotherapist before starting any exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause drowsiness and dizziness, which may affect your ability to drive or operate heavy machinery. Avoid these activities until you know how the medicine affects you. It may also cause stomach upset, so take it with food. Inform your employer if your job involves operating machinery or driving.
🛑 When to Stop This Medicine
Stop this medicine if you experience severe side effects such as gastrointestinal bleeding, allergic reactions, or signs of liver or kidney problems. Do not stop abruptly if you have been on long-term therapy without consulting your doctor. Usually, this medicine is prescribed for short-term use, and your doctor will advise when to stop.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended. Prolonged use of diclofenac can increase the risk of gastrointestinal ulcers, bleeding, kidney impairment, and cardiovascular events. Chlorzoxazone may rarely cause liver toxicity. If long-term therapy is necessary, regular monitoring of liver and kidney function, blood counts, and blood pressure is advised. Discuss with your doctor about alternative treatments for chronic pain.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain and improve muscle strength and flexibility.
Evidence: Well-establishedMay help reduce muscle spasm and pain locally.
Evidence: ModerateSome patients find relief from muscle pain with acupuncture.
Evidence: LimitedMay be an alternative for localized pain with fewer systemic side effects.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are scheduled for vaccination, inform your healthcare provider about all medicines you are taking.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Store it at room temperature and protect it from direct sunlight and moisture. If traveling across time zones, continue your regular dosing schedule as advised by your doctor. Do not pack it in checked luggage if you need it during the flight. Check customs regulations for carrying prescription medicines in your destination country.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Pain relief typically begins within 30 to 60 minutes after taking the tablet, but maximum benefit may take a few days of regular use.
A: It is best taken with food or milk to reduce the risk of stomach irritation and ulcers.
A: Do not take other NSAIDs or painkillers without consulting your doctor, as it may increase the risk of side effects.
A: Take it as soon as you remember if it is not close to the next dose. If it is almost time, skip the missed dose and continue your regular schedule. Do not double dose.
A: This medicine is usually for short-term use. If you have been on it for a longer period, consult your doctor before stopping.
🤔 Common Patient Concerns
🔄 Substitutes for amol mr 250mg/50mg/325mg tablet
View AllAlternative brands with exact same active ingredient:
-
zoxus mr tabletLexus Organics ₹3.50 92.8% CHEAPER
-
angenec plus 250 mg/50 mg/325 mg tabletAngeas Healthcare Ltd ₹3.52 92.8% CHEAPER
-
mahadiclo tabletMankind Pharma Ltd ₹5.81 88.1% CHEAPER
-
playgesic 250 mg/50 mg/325 mg tablet mrShreya Life Sciences Pvt Ltd ₹8.12 83.3% CHEAPER
-
lupizox 250 mg/50 mg/500 mg tabletLupin Ltd ₹8.20 83.2% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken long-term for chronic pain.
Fact: This medicine is intended for short-term use only. Long-term use increases the risk of stomach bleeding, kidney problems, and heart issues. - Myth: It is safe to take this medicine on an empty stomach.
Fact: Taking it with food or milk reduces stomach irritation and the risk of ulcers. - Myth: This medicine is a simple painkiller with no serious risks.
Fact: It contains diclofenac, which carries a boxed warning for cardiovascular and gastrointestinal risks. - Myth: You can stop this medicine abruptly without any issues.
Fact: This medicine is usually taken short-term. If you have been on it for a longer period, consult your doctor before stopping.
🔄 Alternative Options
Generic Alternatives
- Chlorzoxazone + Diclofenac tablet