amnurite beta 5/20 er tablet - Uses, Price, Side Effects & Substitutes
What is amnurite beta 5/20 er tablet used for?
Amnurite Beta 10/40 ER Tablet (Amitriptyline + Propranolol) is used to treat NEURO CNS. It contains Amitriptyline (5mg) + Propranolol (20mg), which Amitriptyline inhibits reuptake of serotonin and norepinephrine; Propranolol blo. Always consult your doctor before use. Take as prescribed.
- Generic Name: Amitriptyline + Propranolol
- Manufacturer: Health N U Therapeutics Pvt Ltd
- Form: Allopathy
- Pregnancy Category: C
- Prescription Required: Yes
๐ amnurite beta 5/20 er tablet Uses & Benefits
Migraine prophylaxis, tension-type headache, depression with anxiety
Off-label uses: Chronic pain, fibromyalgia, panic disorder
๐ Drug Information
| Generic Name(s) | Amitriptyline + Propranolol |
| Brand Name | Amnurite Beta 10/40 ER Tablet |
| Manufacturer | Health N U Therapeutics Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | Tricyclic antidepressant + Beta-blocker |
| Route of Administration | Oral |
| Storage | Store at 20-25ยฐC, protect from light and moisture |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Amitriptyline inhibits reuptake of serotonin and norepinephrine; Propranolol blocks beta-adrenergic receptors
Mechanism Steps
๐ก How to Take amnurite beta 5/20 er tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of amnurite beta 5/20 er tablet
โ Common Side Effects
- Drowsiness
- Dry mouth
- Constipation
- Blurred vision
- Dizziness
- Fatigue
- Bradycardia
- Hypotension
๐จ Serious Side Effects
- Serotonin syndrome
- Cardiac arrhythmias
- Seizures
- Suicidal thoughts
- Severe hypotension
- Bronchospasm
โ ๏ธ Rare Side Effects
- Agranulocytosis
- Cholestatic jaundice
- Photosensitivity
- Extrapyramidal symptoms
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| MAOIs | Major | Hypertensive crisis, serotonin syndrome |
| CYP2D6 inhibitors | Major | Increased amitriptyline levels, toxicity |
| CYP1A2 inhibitors | Major | Increased propranolol levels, bradycardia |
| Other antidepressants | Major | Additive serotonergic effects, risk of serotonin syndrome |
| Antihypertensives | Major | Additive hypotensive effect |
| CNS depressants | Moderate | Enhanced sedation |
| Anticholinergics | Moderate | Additive anticholinergic effects |
| Sympathomimetics | Moderate | Hypertension, arrhythmias |
| Insulin/oral hypoglycemics | Moderate | Hypoglycemia or hyperglycemia |
| Cimetidine | Minor | Increased levels of both drugs |
| Oral contraceptives | Minor | Reduced clearance of amitriptyline |
| Smoking | Minor | Increased metabolism of propranolol |
๐จ Major Interactions
- MAOIs
- CYP2D6 inhibitors
- CYP1A2 inhibitors
- Other antidepressants
- Antihypertensives
โก Moderate Interactions
- CNS depressants
- Anticholinergics
- Sympathomimetics
- Insulin/oral hypoglycemics
โน๏ธ Minor Interactions
- Cimetidine
- Oral contraceptives
- Smoking
๐ฝ๏ธ Food Interactions
Avoid grapefruit juice; take with food to reduce GI upset
๐ท Alcohol Interaction
Increased CNS depression; avoid alcohol
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity, recent MI, severe bradycardia, heart block, asthma, MAOI use within 14 days
๐ Monitoring Parameters
Blood pressure, heart rate, ECG, liver function, mood changes, suicidal ideation
๐คฑ Lactation Safety
Not recommended; excreted in breast milk
๐ Overdose Management
Activated charcoal, supportive care, ECG monitoring, sodium bicarbonate for arrhythmias, beta-agonists for bradycardia
โฐ Missed Dose
Take as soon as remembered; skip if near next dose; do not double