amnuring p tablet sr - Uses, Price, Side Effects & Substitutes
What is amnuring p tablet sr used for?
Amnurite P 10mg/75mg Tablet (Amitriptyline + Pregabalin) is used to treat NEURO CNS. It contains Amitriptyline (10mg) + Pregabalin (75mg), which Amitriptyline: Inhibits reuptake of serotonin and norepinephrine; Pregabalin: Bi. Always consult your doctor before use. Take as prescribed.
- Generic Name: Amitriptyline + Pregabalin
- Manufacturer: Centaur Pharmaceuticals Pvt Ltd
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ amnuring p tablet sr Uses & Benefits
Neuropathic pain, fibromyalgia, generalized anxiety disorder, depression (off-label for pain)
Off-label uses: Migraine prophylaxis, chronic pain, insomnia
๐ Drug Information
| Generic Name(s) | Amitriptyline + Pregabalin |
| Brand Name | Amnurite P 10mg/75mg Tablet |
| Manufacturer | Centaur Pharmaceuticals Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | Tricyclic antidepressant + Gabapentinoid |
| Route of Administration | Oral |
| Storage | Store at 20-25ยฐC (68-77ยฐF), protect from light and moisture |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Amitriptyline: Inhibits reuptake of serotonin and norepinephrine; Pregabalin: Binds to alpha2-delta subunit of voltage-gated calcium channels, reducing calcium influx and neurotransmitter release
Mechanism Steps
๐ก How to Take amnuring p tablet sr
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of amnuring p tablet sr
โ Common Side Effects
- Drowsiness
- Dizziness
- Dry mouth
- Constipation
- Weight gain
- Blurred vision
๐จ Serious Side Effects
- Serotonin syndrome
- QT prolongation
- Seizures
- Suicidal thoughts
- Angle-closure glaucoma
โ ๏ธ Rare Side Effects
- Agranulocytosis
- Cholestatic jaundice
- Stevens-Johnson syndrome
- Rhabdomyolysis
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| MAOIs | Major | Risk of serotonin syndrome, hypertensive crisis |
| CNS depressants | Major | Additive sedation and respiratory depression |
| Anticholinergics | Major | Increased anticholinergic side effects |
| QT-prolonging drugs | Major | Increased risk of torsades de pointes |
| CYP2D6 inhibitors | Major | Increased amitriptyline levels, toxicity risk |
| SSRIs | Moderate | Increased risk of serotonin syndrome |
| SNRIs | Moderate | Increased risk of serotonin syndrome |
| Antihypertensives | Moderate | Additive hypotensive effect |
| Oral contraceptives | Moderate | May reduce amitriptyline efficacy |
| Cimetidine | Minor | Increased amitriptyline levels |
| Fluoxetine | Minor | Increased amitriptyline levels |
| Paroxetine | Minor | Increased amitriptyline levels |
๐จ Major Interactions
- MAOIs
- CNS depressants
- Anticholinergics
- QT-prolonging drugs
- CYP2D6 inhibitors
โก Moderate Interactions
- SSRIs
- SNRIs
- Antihypertensives
- Oral contraceptives
โน๏ธ Minor Interactions
- Cimetidine
- Fluoxetine
- Paroxetine
๐ฝ๏ธ Food Interactions
Grapefruit juice may increase amitriptyline levels; high-fat meal may delay pregabalin absorption
๐ท Alcohol Interaction
Increased CNS depression and sedation; avoid alcohol
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Recent MI, concurrent MAOI use, narrow-angle glaucoma, urinary retention, hypersensitivity
๐ Monitoring Parameters
ECG, liver function, renal function, blood pressure, heart rate, mood, suicidal ideation
๐คฑ Lactation Safety
Amitriptyline: Excreted in milk, use with caution; Pregabalin: Excreted in milk, avoid
๐ Overdose Management
Activated charcoal, supportive care, ECG monitoring, sodium bicarbonate for arrhythmias, flumazenil for CNS depression
โฐ Missed Dose
Take as soon as remembered unless near next dose; skip missed dose if close to next dose