amlovas-m 5/50 tablet pr - Amlodipine (5mg) + Metoprolol Succinate (50mg) medicine

amlovas-m 5/50 tablet pr

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🏭 Macleods Pharmaceuticals Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 20, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Reviewed by
SaathiMed Expert Panel | Sep 20, 2026

What is amlovas-m 5/50 tablet pr used for?

This medicine contains Amlodipine (5mg) + Metoprolol Succinate (50mg) and is used to treat CARDIAC. Amlodipine inhibits calcium influx across cell membranes, causing vasodilation; Metoprolol selective. Always consult your doctor before use.

  • Generic Name: Amlodipine + Metoprolol Succinate
  • Manufacturer: Macleods Pharmaceuticals Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Category A
  • Prescription Required: Yes
💡 Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

💊 amlovas-m 5/50 tablet pr Uses & Benefits

Hypertension, stable angina, chronic heart failure (metoprolol).

Off-label uses: Migraine prophylaxis (metoprolol), Raynaud's phenomenon (amlodipine).

📋 Drug Information

Generic Name(s)Amlodipine + Metoprolol Succinate
Brand NameAmtas-M 50 Tablet PR
ManufacturerMacleods Pharmaceuticals Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassCARDIAC
Action ClassAntihypertensive combination (Calcium channel blocker + Beta-blocker)
Route of AdministrationOral
StorageStore at 20-25°C, protect from light and moisture.
Shelf LifeAs per manufacturer

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionAmlodipine: Well absorbed after oral administration; Metoprolol: Rapidly and completely absorbed from GI tract.
DistributionAmlodipine: Large volume of distribution (~21 L/kg); Metoprolol: Distributed widely, crosses blood-brain barrier.
Protein BindingAmlodipine: ~93%; Metoprolol: ~12%
MetabolismAmlodipine: Extensively hepatic via CYP3A4; Metoprolol: Hepatic via CYP2D6.
Half-LifeAmlodipine: 30-50 hours; Metoprolol: 3-7 hours.
ExcretionAmlodipine: 60% renal, 20-25% fecal; Metoprolol: <5% unchanged in urine.
BioavailabilityAmlodipine: 64-90%; Metoprolol: 50% (first-pass effect).
Onset of ActionAmlodipine: 30-60 minutes; Metoprolol: 1-2 hours.
Peak Plasma TimeAmlodipine: 6-12 hours; Metoprolol: 1-2 hours.
Duration of ActionAmlodipine: 24 hours; Metoprolol: 12-24 hours.

How It Works

Amlodipine inhibits calcium influx across cell membranes, causing vasodilation; Metoprolol selectively blocks beta-1 adrenergic receptors, reducing heart rate and contractility.

Mechanism Steps

1Amlodipine binds to L-type calcium channels in vascular smooth muscle and cardiac muscle.
2Inhibits calcium influx, leading to vasodilation and reduced peripheral resistance.
3Metoprolol selectively blocks beta-1 adrenergic receptors in the heart.
4Reduces heart rate, contractility, and cardiac output.
5Combined effect lowers blood pressure and decreases myocardial oxygen demand.

💡 How to Take amlovas-m 5/50 tablet pr

Follow your doctor's prescription exactly.

⚠️ Side Effects of amlovas-m 5/50 tablet pr

✅ Common Side Effects

Edema
Dizziness
Fatigue
Headache
Nausea
Bradycardia

🚨 Serious Side Effects

Heart block
Severe hypotension
Bronchospasm
Hepatotoxicity

⚠️ Rare Side Effects

Leukopenia
Thrombocytopenia
Stevens-Johnson syndrome
Pulmonary fibrosis

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Ketoconazole Major Increased amlodipine levels, risk of toxicity
Fluoxetine Major Increased metoprolol levels, bradycardia
NSAIDs Moderate Reduced antihypertensive effect
Digoxin Moderate Increased risk of bradycardia
Grapefruit juice Minor Increased amlodipine absorption

🚨 Major Interactions

  • CYP3A4 inhibitors (e.g., ketoconazole)
  • CYP2D6 inhibitors (e.g., fluoxetine)
  • Beta-blockers (additive bradycardia)
  • Calcium channel blockers (additive hypotension)

⚡ Moderate Interactions

  • NSAIDs
  • Digoxin
  • Clonidine
  • Cimetidine

🍷 Alcohol Interaction

May enhance hypotensive effects; avoid excessive alcohol.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity, cardiogenic shock, severe bradycardia, heart block, sick sinus syndrome, uncontrolled heart failure, severe hypotension.

🤱 Lactation Safety

Excreted in breast milk; use with caution.

💊 Overdose Management

Supportive care; atropine for bradycardia, vasopressors for hypotension, calcium gluconate for amlodipine overdose.

⏰ Missed Dose

Take as soon as remembered; skip if near next dose; do not double.

🔄 Substitutes for amlovas-m 5/50 tablet pr

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

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