Amleod H 5mg/12.5mg Tablet: Complete Guide to Uses, Side Effects, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe dizziness or fainting
- Chest pain or difficulty breathing
- Swelling of the face, lips, tongue, or throat
- Decreased urine output or no urine
- Severe abdominal pain or vomiting
- Irregular heartbeat or palpitations
- Yellowing of the skin or eyes
- Severe headache with visual changes
If experiencing severe symptoms, call emergency services immediately.
What is amlotri h 5mg/12.5mg tablet used for?
This medicine is a combination of Amlodipine 5 mg and Hydrochlorothiazide 12.5 mg used to treat high blood pressure. It works by relaxing blood vessels and removing excess fluid from the body. It is taken once daily orally, usually with or without food. Common side effects include dizziness, headache, and ankle swelling. It is not recommended during pregnancy or breastfeeding.
- Generic Name: Amlodipine (5mg) + Hydrochlorothiazide (12.5mg)
- Manufacturer: Cadbless Life Care
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 amlotri h 5mg/12.5mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा उच्च रक्तचाप (हाई ब्लड प्रेशर) के इलाज के लिए इस्तेमाल की जाती है। इसमें एम्लोडिपिन और हाइड्रोक्लोरोथियाजाइड दो सक्रिय तत्व होते हैं। एम्लोडिपिन रक्त वाहिकाओं को आराम देता है और हाइड्रोक्लोरोथियाजाइड शरीर से अतिरिक्त नमक और पानी को बाहर निकालता है। यह दवा रक्तचाप को नियंत्रित करने में मदद करती है और स्ट्रोक, दिल के दौरे तथा किडनी की समस्याओं का खतरा कम करती है। इसे आमतौर पर दिन में एक बार मुँह से लिया जाता है।
साइड इफेक्ट्स: इस दवा के आम दुष्प्रभावों में चक्कर आना, सिरदर्द, टखनों में सूजन, थकान और बार-बार पेशाब आना शामिल हैं। कुछ लोगों को मतली, पेट दर्द या त्वचा पर चकत्ते भी हो सकते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन अगर आपको सांस लेने में कठिनाई, चेहरे या गले में सूजन, या बहुत कम रक्तचाप महसूस हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। अपनी मर्जी से दवा की मात्रा न बदलें और न ही बंद करें। चक्कर आने पर धीरे-धीरे उठें। पर्याप्त पानी पिएं। शराब से बचें क्योंकि इससे चक्कर और कम रक्तचाप बढ़ सकता है। नियमित रूप से रक्तचाप, किडनी फंक्शन और इलेक्ट्रोलाइट्स की जांच कराएं। गर्भवती या स्तनपान कराने वाली महिलाएं इस दवा का सेवन न करें।
💊 amlotri h 5mg/12.5mg tablet Uses & Benefits
[{"condition":"Hypertension","description":"This medicine is used to lower high blood pressure in adults when combination therapy is appropriate.","evidence":"Well-established"}]
Off-label uses: []
Primary treatment for: Hypertension
Also treats: Heart failure, Chronic kidney disease, Stroke prevention
📋 Drug Information
| Generic Name(s) | Amlodipine (5mg) + Hydrochlorothiazide (12.5mg) |
| Brand Name | amlotri h 5mg/12.5mg tablet |
| Manufacturer | Cadbless Life Care |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | The World Health Organization recommends thiazide diuretics and calcium channel blockers as first-line agents for the treatment of hypertension in adults. Combination therapy is recommended when monotherapy is insufficient. |
| ICMR Guideline | The Indian Council of Medical Research guidelines recommend calcium channel blockers and thiazide diuretics as preferred initial therapy for hypertension in Indian adults, often in combination for better blood pressure control. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two antihypertensive agents with complementary mechanisms. Amlodipine blocks L-type calcium channels in vascular smooth muscle, causing vasodilation and reduced peripheral resistance. Hydrochlorothiazide inhibits the sodium-chloride symporter in the distal convoluted tubule of the kidney, increasing excretion of sodium, chloride, and water, which reduces plasma volume and cardiac output initially, and later lowers peripheral resistance.
Mechanism Steps
💡 How to Take amlotri h 5mg/12.5mg tablet
Strength: Tablet containing Amlodipine 5 mg and Hydrochlorothiazide 12.5 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet of Amlodipine 5 mg and Hydrochlorothiazide 12.5 mg taken orally once daily. The dose may be increased based on blood pressure response, but the maximum recommended dose is Amlodipine 10 mg and Hydrochlorothiazide 25 mg once daily. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the blood pressure-lowering effects of this medicine. Start with a low dose and monitor closely for dizziness, falls, and electrolyte imbalances. Dose must be individualized by a qualified clinician. |
| Renal Impairment | In patients with mild to moderate renal impairment, no dose adjustment is usually needed, but monitor kidney function and electrolytes. In severe renal impairment (creatinine clearance <30 mL/min), hydrochlorothiazide may be ineffective and is not recommended. Dose must be individualized by a qualified clinician. |
| Hepatic Impairment | In patients with hepatic impairment, amlodipine clearance may be reduced. Start with a low dose and titrate slowly. Hydrochlorothiazide should be used with caution. Dose must be individualized by a qualified clinician. |
| Maximum Daily Dose | The maximum recommended daily dose is Amlodipine 10 mg and Hydrochlorothiazide 25 mg once daily. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of amlotri h 5mg/12.5mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Potassium-sparing diuretics | Major | |
| Lithium | Major | |
| NSAIDs | Major | |
| CYP3A4 inhibitors | Major | |
| Beta-blockers | Moderate | |
| Corticosteroids | Moderate | |
| Carbamazepine | Moderate | |
| Antacids | Minor | |
| Cholestyramine | Minor |
🚨 Major Interactions
- Potassium-sparing diuretics (e.g., spironolactone, triamterene)
- Lithium
- NSAIDs (e.g., ibuprofen, naproxen)
- CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin, ritonavir)
⚡ Moderate Interactions
- Beta-blockers (e.g., metoprolol, atenolol)
- Corticosteroids
- Carbamazepine
🍷 Alcohol Interaction
Alcohol can enhance the blood pressure-lowering effect of this medicine, leading to dizziness, lightheadedness, and fainting. It is advisable to avoid or limit alcohol consumption while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to amlodipine, hydrochlorothiazide, or other thiazide diuretics","Severe hypotension","Severe aortic stenosis","Anuria","Severe renal impairment (creatinine clearance
⚠️ Warnings & Precautions
["This medicine may cause dizziness; avoid driving or operating machinery until you know how it affects you.","Stand up slowly to prevent falls due to low blood pressure.","Monitor for signs of electrolyte imbalance such as muscle cramps, weakness, or confusion.","Avoid excessive sun exposure as hydrochlorothiazide can cause photosensitivity.","Inform your doctor if you have a history of gout, diabetes, or lupus, as hydrochlorothiazide can worsen these conditions.","Do not use potassium supplements or salt substitutes without medical advice.","This medicine can cause dry mouth and thirst; maintain adequate hydration."]
🤱 Lactation Safety
Both amlodipine and hydrochlorothiazide are excreted in breast milk. Hydrochlorothiazide may suppress lactation and cause electrolyte imbalances in the infant. This medicine is not recommended during breastfeeding. Consult your doctor for safer alternatives.
💊 Overdose Management
Overdose of this medicine can cause severe hypotension, dizziness, fainting, and electrolyte imbalances. If you suspect an overdose, seek immediate medical attention. Treatment is supportive and may include intravenous fluids, monitoring of vital signs, and electrolyte correction. There is no specific antidote.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not change the dose or stop taking it without medical advice. Stand up slowly from a sitting or lying position to avoid dizziness. Drink enough water to stay hydrated, especially if you sweat a lot or have diarrhea. Avoid alcohol as it can increase dizziness and low blood pressure. Have your blood pressure, kidney function, and electrolyte levels checked regularly. Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding. Do not take potassium supplements or salt substitutes without consulting your doctor. Keep all follow-up appointments.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to the blood pressure-lowering effects of this medicine and are at higher risk of dizziness, falls, and electrolyte imbalances. Start with a low dose and monitor closely. Regular monitoring of kidney function and electrolytes is recommended.
🤰 Pregnancy Planning (TTC)
This medicine is not recommended during pregnancy or when planning pregnancy. If you are planning to become pregnant, consult your doctor to switch to a safer alternative before conception. Effective contraception is advised while taking this medicine.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine before any surgery. It may need to be temporarily stopped before surgery to avoid excessive blood pressure lowering during anesthesia. Follow your doctor's instructions regarding when to resume.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. It may cause dry mouth or dizziness. Your dentist may need to monitor your blood pressure during the procedure. Continue taking your medicine as usual unless advised otherwise.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Exercise is generally safe while taking this medicine, but you may feel dizzy or lightheaded during the first few days or after dose changes. Start slowly and stay hydrated. Avoid strenuous exercise in hot weather. If you experience chest pain, severe shortness of breath, or fainting, stop exercising and seek medical attention.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness, especially when standing up quickly. Avoid driving or operating heavy machinery until you know how it affects you. It may also cause increased urination, so plan your work schedule accordingly. Most people can continue their normal activities with some adjustments.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience severe side effects such as fainting, severe allergic reactions, or irregular heartbeat, seek immediate medical attention. Your doctor may adjust the dose or switch to a different medicine if needed.
📅 Long-Term Use Effects
Long-term use of this medicine is generally safe and effective for controlling blood pressure. However, it requires regular monitoring of kidney function, electrolytes, and blood pressure. Hydrochlorothiazide can cause electrolyte imbalances and increase blood sugar and uric acid levels. Amlodipine can cause persistent ankle swelling. Regular follow-up with your doctor is essential to adjust the dose and monitor for any complications.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Diet, exercise, weight loss, and stress reduction can help lower blood pressure and may reduce the need for medication.
Evidence: Well-establishedACE inhibitors, ARBs, beta-blockers, or other combinations may be used if this medicine is not suitable.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are scheduled for any vaccination, inform your healthcare provider about all medicines you are taking.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss or temperature extremes. If traveling across time zones, continue taking your dose at the same local time as much as possible, but consult your doctor for specific advice. Store away from direct sunlight and moisture. Check customs regulations for carrying prescription medicines in your destination country.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts lowering blood pressure within 24 to 48 hours, but the full effect may take 1 to 2 weeks. It is important to take it regularly as prescribed.
A: Yes, you can take this medicine with or without food. Taking it with food may reduce stomach upset.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: No, do not stop taking this medicine without consulting your doctor. Blood pressure may rise again if you stop suddenly.
A: This medicine is not recommended during pregnancy as it may harm the fetus. Consult your doctor for alternative treatments.
🤔 Common Patient Concerns
🔄 Substitutes for amlotri h 5mg/12.5mg tablet
View AllAlternative brands with exact same active ingredient:
-
amoline h 5mg/12.5mg tabletZeelab Pharmacy Pvt Ltd ₹10.00 77.3% CHEAPER
-
davaindia amlodipine+hydrochlorothiazide 5mg/12.5mg tabletDavaindia Generic Pharmacy ₹12.00 72.8% CHEAPER
-
angicam-h 5mg/12.5mg tabletBlue Cross Laboratories Ltd ₹15.47 64.9% CHEAPER
-
StayHappi Amlodipine+Hydrochlorothiazide 5mg/12.5mg TabletSarvagunaushdhi Pvt Ltd ₹23.43 46.8% CHEAPER
-
amvio h 5 mg/12.5 mg tabletSalud Care India Pvt Ltd ₹27.62 37.3% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure high blood pressure permanently.
Fact: This medicine controls high blood pressure but does not cure it. Lifestyle changes and continued treatment are usually needed. - Myth: You can stop taking this medicine once your blood pressure is normal.
Fact: Blood pressure returns to high levels if you stop taking the medicine. Always consult your doctor before stopping. - Myth: This medicine causes kidney failure in everyone.
Fact: Kidney problems are rare and can be monitored with regular blood tests. The benefits of blood pressure control usually outweigh the risks. - Myth: Taking this medicine means you can eat as much salt as you want.
Fact: A high-salt diet can reduce the effectiveness of this medicine. A low-salt diet is recommended.
🔄 Alternative Options
Generic Alternatives
- Amlodipine 5 mg + Hydrochlorothiazide 12.5 mg tablet
Brand Alternatives
- Amleod H 5mg/12.5mg Tablet