Amloss Beta Tablet PR - Uses, Price, Side Effects
What is amloss-beta tablet pr used for?
Amloss Beta Tablet PR is a combination of Amlodipine (a calcium channel blocker) and Metoprolol Succinate (a beta blocker) used to treat hypertension and angina. Amlodipine relaxes blood vessels, while Metoprolol reduces heart rate and workload, together lowering blood pressure and preventing chest pain.
- Generic Name: Amlodipine + Metoprolol Succinate
- Manufacturer: Dansan Medichem
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ amloss-beta tablet pr Uses & Benefits
Hypertension, stable angina, chronic heart failure (metoprolol).
Off-label uses: Migraine prophylaxis (metoprolol), Raynaud's phenomenon (amlodipine).
๐ Drug Information
| Generic Name(s) | Amlodipine + Metoprolol Succinate |
| Brand Name | Amtas-M 50 Tablet PR |
| Manufacturer | Dansan Medichem |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | Antihypertensive combination (Calcium channel blocker + Beta-blocker) |
| Route of Administration | Oral |
| Storage | Store at 20-25ยฐC, protect from light and moisture. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Amlodipine inhibits calcium influx across cell membranes, causing vasodilation; Metoprolol selectively blocks beta-1 adrenergic receptors, reducing heart rate and contractility.
Mechanism Steps
๐ก How to Take amloss-beta tablet pr
Follow your doctor's prescription exactly.
Dosage Timeline
โ ๏ธ Side Effects of amloss-beta tablet pr
โ Common Side Effects
- Edema
- Dizziness
- Fatigue
- Headache
- Nausea
- Bradycardia
๐จ Serious Side Effects
- Heart block
- Severe hypotension
- Bronchospasm
- Hepatotoxicity
โ ๏ธ Rare Side Effects
- Leukopenia
- Thrombocytopenia
- Stevens-Johnson syndrome
- Pulmonary fibrosis
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | Increased bleeding risk |
| NSAIDs | Moderate | Reduced antihypertensive effect |
| Digoxin | Moderate | Increased bradycardia risk |
๐จ Major Interactions
- CYP3A4 inhibitors (e.g., ketoconazole)
- CYP2D6 inhibitors (e.g., fluoxetine)
- Beta-blockers (additive bradycardia)
- Calcium channel blockers (additive hypotension)
โก Moderate Interactions
- NSAIDs
- Digoxin
- Clonidine
- Cimetidine
โน๏ธ Minor Interactions
- Grapefruit juice (amlodipine)
- Antacids
- Rifampin
๐ฝ๏ธ Food Interactions
Grapefruit juice may increase amlodipine levels; avoid high-fat meals with metoprolol.
๐ท Alcohol Interaction
May enhance hypotensive effects; avoid excessive alcohol.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity, cardiogenic shock, severe bradycardia, heart block, sick sinus syndrome, uncontrolled heart failure, severe hypotension.
๐ Monitoring Parameters
Blood pressure, heart rate, ECG, renal function, liver enzymes.
๐คฑ Lactation Safety
Excreted in breast milk; use with caution.
๐ Overdose Management
Supportive care; atropine for bradycardia, vasopressors for hypotension, calcium gluconate for amlodipine overdose.
โฐ Missed Dose
Take as soon as remembered; skip if near next dose; do not double.