amitor 75mg tablet

4.5 (20 reviews)

Amitriptyline (75mg)

🏭 Torrent Pharmaceuticals Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Aug 22, 2026

📋 Prescription Required 💊 Generic Available

Medically Reviewed

SaathiMed Expert Panel | Aug 22, 2026

What is amitor 75mg tablet used for?

Amitone 10mg Tablet (Amitriptyline) is used to treat NEURO CNS. It contains Amitriptyline (75mg), which Inhibits reuptake of serotonin and norepinephrine in the central nervous system,. Always consult your doctor before use. Take as prescribed.

Generic Name: Amitriptyline
Manufacturer: Torrent Pharmaceuticals Ltd
Form: Allopathy
Pregnancy Category: A
Prescription Required: Yes

💡 Did You Know? The Indian pharmaceutical market is expected to reach $130 billion by 2030.

💊 amitor 75mg tablet Uses & Benefits

Major depressive disorder, neuropathic pain, migraine prophylaxis, anxiety disorders, insomnia (off-label).

Off-label uses: Insomnia, chronic pain, fibromyalgia, irritable bowel syndrome, postherpetic neuralgia, diabetic neuropathy.

📋 Drug Information

Generic Name(s)	Amitriptyline
Brand Name	Amitone 10mg Tablet
Manufacturer	Torrent Pharmaceuticals Ltd
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	NEURO CNS
Action Class	Tricyclic antidepressants
Route of Administration	Oral
Storage	Store at 20-25°C (68-77°F); protect from light and moisture.
Shelf Life	As per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionWell absorbed from the gastrointestinal tract; peak plasma concentrations occur within 2-4 hours.

DistributionWidely distributed throughout the body; crosses the blood-brain barrier and placenta.

Protein BindingApproximately 96% bound to plasma proteins.

MetabolismExtensively metabolized in the liver via CYP2D6, CYP3A4, and CYP1A2; major metabolite is nortriptyline (active).

Half-LifeApproximately 15-24 hours (amitriptyline); nortriptyline half-life is 18-44 hours.

ExcretionPrimarily excreted in urine as metabolites; small amount in feces.

BioavailabilityApproximately 30-60% due to first-pass metabolism.

Onset of ActionTherapeutic effects may take 2-4 weeks; sedative effects occur within hours.

Peak Plasma Time2-4 hours after oral administration.

Duration of ActionEffects last for 24-48 hours; steady-state achieved in 3-10 days.

How It Works

Inhibits reuptake of serotonin and norepinephrine in the central nervous system, increasing their synaptic concentrations.

Mechanism Steps

1Amitriptyline binds to and inhibits serotonin transporter (SERT) and norepinephrine transporter (NET) on presynaptic neurons.

2Inhibition of reuptake increases synaptic concentrations of serotonin and norepinephrine.

3Enhanced serotonergic and noradrenergic neurotransmission in the central nervous system.

💡 How to Take amitor 75mg tablet

Follow your doctor's prescription exactly.

⚠️ Side Effects of amitor 75mg tablet

✅ Common Side Effects

Drowsiness
Dry mouth
Constipation
Blurred vision
Urinary retention
Weight gain
Dizziness
Headache

🚨 Serious Side Effects

Serotonin syndrome
QT prolongation
Arrhythmias
Seizures
Suicidal thoughts
Agranulocytosis
Hepatotoxicity

⚠️ Rare Side Effects

Paralytic ileus
Bone marrow suppression
Allergic reactions
Photosensitivity
Gynecomastia
Galactorrhea

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug	Severity	Effect
MAOIs	Major	Risk of serotonin syndrome; hypertensive crisis
CYP2D6 inhibitors	Major	Increased amitriptyline levels, toxicity
CYP3A4 inhibitors	Major	Increased amitriptyline levels
CYP1A2 inhibitors	Major	Increased amitriptyline levels
Other serotonergic drugs	Major	Risk of serotonin syndrome
Anticholinergics	Major	Additive anticholinergic effects
CNS depressants	Major	Enhanced sedation, respiratory depression
Antihypertensives	Major	Increased hypotensive effect
QTc-prolonging drugs	Major	Increased risk of arrhythmias
Disulfiram	Major	Delirium, confusion
Cimetidine	Moderate	Increased amitriptyline levels
Fluoxetine	Moderate	Increased amitriptyline levels
Paroxetine	Moderate	Increased amitriptyline levels
Bupropion	Moderate	Increased amitriptyline levels
Terbinafine	Moderate	Increased amitriptyline levels
Quinidine	Moderate	Increased amitriptyline levels
Ritonavir	Moderate	Increased amitriptyline levels
Clonidine	Moderate	Decreased antihypertensive effect
Guanethidine	Moderate	Decreased antihypertensive effect
Sympathomimetics	Moderate	Increased risk of hypertension
Oral contraceptives	Minor	Possible decreased amitriptyline efficacy
Smoking	Minor	Increased metabolism, decreased levels
St. John's Wort	Minor	Possible serotonin syndrome risk
Valerian	Minor	Additive sedation
Kava	Minor	Additive sedation

🚨 Major Interactions

MAOIs
CYP2D6 inhibitors
CYP3A4 inhibitors
CYP1A2 inhibitors
Other serotonergic drugs
Anticholinergics
CNS depressants
Antihypertensives
QTc-prolonging drugs
Disulfiram

⚡ Moderate Interactions

Cimetidine
Fluoxetine
Paroxetine
Bupropion
Terbinafine
Quinidine
Ritonavir
Clonidine
Guanethidine
Sympathomimetics

ℹ️ Minor Interactions

Oral contraceptives
Smoking (increases metabolism)
St. John's Wort
Valerian
Kava

🍽️ Food Interactions

Grapefruit juice may increase plasma levels; avoid excessive caffeine.

🍷 Alcohol Interaction

Increased CNS depression; avoid alcohol.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity, recent MI, concurrent MAOI use, narrow-angle glaucoma, urinary retention, severe liver disease.

📊 Monitoring Parameters

ECG, liver function tests, blood pressure, heart rate, mental status, suicidal ideation.

🤱 Lactation Safety

Excreted in breast milk; use with caution, monitor infant for sedation and anticholinergic effects.

💊 Overdose Management

Supportive care; activated charcoal, ECG monitoring, sodium bicarbonate for arrhythmias, physostigmine for severe anticholinergic symptoms.

⏰ Missed Dose

If missed, take as soon as remembered unless near next dose; do not double dose.

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 22, 2026

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🔄 Substitutes for amitor 75mg tablet

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Alternative brands with exact same active ingredient (Amitriptyline (75mg)):

Medical Note: Always consult your doctor before switching medications.

⭐ User Reviews

Happy Patient Jul 10, 2026

This medicine was effective for me. I followed the doctor's advice.

Trusted Reviewer Jul 10, 2026

Effective and reliable. Worked as expected.

Certified Buyer Jul 10, 2026