Amitax 50mg Injection (Amikacin): Comprehensive Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Decreased urine output or no urine output
- Swelling in legs, ankles, or feet
- Ringing in the ears or hearing loss
- Dizziness or vertigo
- Muscle weakness or difficulty breathing
- Severe allergic reaction: swelling of face, lips, throat, or difficulty breathing
- Yellowing of skin or eyes
- Unusual bruising or bleeding
- Severe abdominal pain or bloody diarrhea
- Confusion or seizures
If experiencing severe symptoms, call emergency services immediately.
What is amitax 50mg injection used for?
This medicine is an intravenous antibiotic containing amikacin, used to treat serious bacterial infections. It works by stopping bacteria from making proteins, which kills them. It is given by a healthcare professional in a hospital setting and requires monitoring of kidney function and hearing.
- Generic Name: Amikacin
- Manufacturer: Alkem Laboratories Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 amitax 50mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा एक एंटीबायोटिक है जिसका उपयोग गंभीर बैक्टीरियल संक्रमणों के इलाज के लिए किया जाता है। इसमें अमिकासिन नामक सक्रिय तत्व होता है, जो बैक्टीरिया को प्रोटीन बनाने से रोकता है और उन्हें मार देता है। यह दवा अस्पताल में नस के माध्यम से दी जाती है और इसका उपयोग निमोनिया, मूत्र मार्ग संक्रमण, रक्त संक्रमण, पेट के संक्रमण, त्वचा संक्रमण और नवजात शिशुओं के संक्रमण के इलाज में किया जाता है। यह दवा वायरल संक्रमण जैसे सर्दी-जुकाम के लिए प्रभावी नहीं है। इसका उपयोग केवल डॉक्टर की सलाह और निगरानी में ही किया जाना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, दस्त, सिरदर्द, इंजेक्शन की जगह पर दर्द और हल्के दाने शामिल हैं। गंभीर दुष्प्रभावों में गुर्दे की क्षति, सुनने की क्षमता में कमी, कान में घंटी बजना, चक्कर आना, मांसपेशियों में कमजोरी और सांस लेने में कठिनाई शामिल हैं। दुर्लभ मामलों में रक्त विकार, तंत्रिका क्षति और आंखों की समस्याएं हो सकती हैं। यदि आपको कान में आवाज सुनाई दे, सुनने में परेशानी हो, पेशाब कम आए या सांस लेने में तकलीफ हो, तो तुरंत डॉक्टर को बताएं।
सुरक्षा सलाह: यह दवा केवल अस्पताल या क्लिनिक में योग्य स्वास्थ्य पेशेवर द्वारा ही दी जानी चाहिए। इलाज से पहले अपने डॉक्टर को गुर्दे, सुनने, मांसपेशियों की समस्याओं या एंटीबायोटिक से एलर्जी के बारे में बताएं। इलाज के दौरान गुर्दे की कार्यप्रणाली और सुनने की जांच की जाएगी। पर्याप्त पानी पिएं जब तक डॉक्टर अन्यथा न कहें। बेहतर महसूस होने पर भी इलाज बीच में न रोकें। बिना डॉक्टर की सलाह के अन्य दवाएं न लें जो गुर्दे या कान को नुकसान पहुंचा सकती हैं। यह दवा घर पर स्वयं न लें।
💊 amitax 50mg injection Uses & Benefits
[{"condition":"Hospital-acquired pneumonia","description":"Used to treat pneumonia acquired during hospital stay, especially when caused by gram-negative bacteria resistant to other antibiotics.","evidence":"Well-established"},{"condition":"Complicated urinary tract infections","description":"Effective against serious kidney and bladder infections caused by susceptible gram-negative bacteria.","evidence":"Well-established"},{"condition":"Bloodstream infections (sepsis)","description":"Used in combination with other antibiotics for severe bloodstream infections.","evidence":"Well-established"},{"condition":"Intra-abdominal infections","description":"Used as part of combination therapy for complicated intra-abdominal infections.","evidence":"Well-established"},{"condition":"Skin and soft tissue infections","description":"Used for severe skin infections caused by susceptible organisms.","evidence":"Well-established"},{"condition":"Neonatal sepsis","description":"Used in newborns with suspected or confirmed sepsis, with careful dosing and monitoring.","evidence":"Well-established"},{"condition":"Bone and joint infections","description":"Used in some cases of osteomyelitis and septic arthritis when caused by susceptible bacteria.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Mycobacterium avium complex (MAC) infections","description":"Sometimes used as part of combination therapy for MAC infections in immunocompromised patients.","evidence":"Limited"},{"condition":"Cystic fibrosis exacerbations","description":"May be used in inhaled or intravenous form for certain lung infections in cystic fibrosis, though not a standard first-line option.","evidence":"Limited"}]
Primary treatment for: Serious bacterial infections
Also treats: Hospital-acquired pneumonia, Complicated urinary tract infections, Bloodstream infections, Intra-abdominal infections, Skin and soft tissue infections, Neonatal sepsis, Bone and joint infections
📋 Drug Information
| Generic Name(s) | Amikacin |
| Brand Name | Amikacin Sulphate 500mg Injection |
| Manufacturer | Alkem Laboratories Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | OPHTHAL |
| Action Class | Aminoglycosides |
| Route of Administration | Intravenous (IV) infusion. This medicine is given by a healthcare professional, typically over 30 to 60 minutes. It should not be administered as a rapid intravenous push |
| Storage | Store this medicine in its original container at controlled room temperature, between 20°C and 25°C (68°F to 77°F). Protect from light and freezing. Do not use if the solution is discolored or contains particulate matter. Once diluted for infusion, the solution should be used within the time specified by the manufacturer or pharmacist. Follow institutional guidelines for storage of compounded sterile products. |
| Shelf Life | The shelf life of this medicine is typically 24 to 36 months from the date of manufacture, depending on the manufacturer and packaging. Refer to the product label for the exact expiration date. Do not use after the expiration date. |
| WHO Guideline | The World Health Organization (WHO) includes amikacin in its Model List of Essential Medicines for the treatment of serious bacterial infections. WHO guidelines recommend amikacin as an option for the treatment of multidrug-resistant tuberculosis and certain neonatal infections, but specific recommendations vary by condition and region. Always follow local guidelines and consult a specialist. |
| ICMR Guideline | The Indian Council of Medical Research (ICMR) has published treatment guidelines for antimicrobial use that include amikacin for serious infections caused by susceptible organisms. ICMR emphasizes the importance of culture-directed therapy and antimicrobial stewardship to prevent resistance. Consult the latest ICMR guidelines for specific recommendations. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine belongs to the aminoglycoside class of antibiotics. It works by binding irreversibly to the 30S ribosomal subunit of susceptible bacteria, which interferes with protein synthesis. Specifically, it causes misreading of messenger RNA and blocks the initiation of protein translation, leading to the production of abnormal proteins and disruption of bacterial cell membrane integrity. This results in bacterial cell death. Amikacin is particularly effective against many gram-negative bacteria, including Pseudomonas aeruginosa, and some gram-positive bacteria, but it is not effective against anaerobic bacteria or fungi.
Mechanism Steps
💡 How to Take amitax 50mg injection
Strength: This medicine is available as a sterile injection containing 50 mg of amikacin per vial or per specified volume. The concentration may vary; refer to the product label for exact strength.
Dosage Information
| Adult Dosage | The dose of this medicine must be individualized by a qualified clinician based on the indication, severity of infection, patient weight, renal function, and other factors. For adults with normal renal function, a common regimen is 15 mg/kg per day, which may be given as a single daily dose or divided into two or three equal doses. For serious infections, doses up to 20 mg/kg per day may be used. The duration of therapy depends on the type of infection and clinical response. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. In general, aminoglycoside dosing in children is weight-based and requires careful monitoring. Doses must be individualized by a qualified clinician. |
| Elderly Dosage | Elderly patients are at increased risk of nephrotoxicity and ototoxicity due to age-related decline in renal function. Doses should be adjusted based on creatinine clearance. Monitoring of renal function and hearing is essential. Dose must be individualized by a qualified clinician. |
| Renal Impairment | In patients with renal impairment, the dose and/or dosing interval must be adjusted. The dose is typically reduced or the interval extended based on creatinine clearance. For patients with severe renal impairment, a loading dose may be given followed by reduced maintenance doses. Therapeutic drug monitoring is recommended to avoid toxicity. Dose must be individualized by a qualified clinician. |
| Hepatic Impairment | No specific dosage adjustment is required for hepatic impairment, as amikacin is not metabolized by the liver. However, patients with combined hepatic and renal impairment should be monitored closely. |
| Maximum Daily Dose | The maximum recommended daily dose is 15 to 20 mg/kg per day for adults with normal renal function. Doses above this increase the risk of toxicity. The maximum daily dose should not exceed 1.5 grams per day in adults with normal renal function, unless in specific clinical situations and with close monitoring. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of amitax 50mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Other aminoglycosides | Major | |
| Loop diuretics | Major | |
| Vancomycin | Major | |
| Neuromuscular blockers | Major | |
| Amphotericin B | Major | |
| Cyclosporine | Major | |
| Cephaloridine | Major | |
| Indomethacin | Moderate | |
| General anesthetics | Moderate | |
| Beta-lactam antibiotics | Moderate |
🚨 Major Interactions
- Other aminoglycosides (e.g., gentamicin, tobramycin)
- Loop diuretics (e.g., furosemide, ethacrynic acid)
- Vancomycin
- Neuromuscular blocking agents (e.g., succinylcholine, vecuronium)
- Amphotericin B
- Cyclosporine
- Cephalosporins (e.g., cephaloridine)
⚡ Moderate Interactions
- Indomethacin
- General anesthetics
- Beta-lactam antibiotics (e.g., penicillins, cephalosporins)
🍷 Alcohol Interaction
There is no direct interaction between alcohol and amikacin. However, alcohol can worsen dehydration and kidney function, which may increase the risk of amikacin-related kidney damage. It is advisable to avoid alcohol during treatment, especially if you have any kidney problems.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to amikacin or other aminoglycosides","Pre-existing severe renal impairment (unless benefits outweigh risks)","Pre-existing hearing loss or vestibular dysfunction","Myasthenia gravis (due to risk of neuromuscular blockade)","Concurrent use with other nephrotoxic or ototoxic drugs (relative contraindication)"]
⚠️ Warnings & Precautions
["Nephrotoxicity: Monitor renal function closely. Risk increases with high trough levels, prolonged therapy, and concurrent nephrotoxic drugs.","Ototoxicity: May cause irreversible hearing loss and vestibular damage. Monitor hearing, especially in elderly and those with renal impairment.","Neuromuscular blockade: May cause muscle weakness and respiratory paralysis, particularly in patients with myasthenia gravis or receiving neuromuscular blockers.","Superinfection: Prolonged use may lead to overgrowth of non-susceptible organisms, including fungi.","Pregnancy: Category D. May cause fetal harm. Use only if clearly needed.","Lactation: Excreted in breast milk. Caution advised.","Pediatric use: Safety and efficacy not established in all pediatric age groups. Use with caution.","Geriatric use: Elderly patients are at higher risk of nephrotoxicity and ototoxicity due to reduced renal function."]
🤱 Lactation Safety
Amikacin is excreted in human milk in small amounts. Because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother. Caution is advised.
💊 Overdose Management
There is no specific antidote for amikacin overdose. Management is supportive and symptomatic. If overdose occurs, discontinue the drug immediately. Maintain adequate hydration and monitor renal function, hearing, and neuromuscular function closely. Hemodialysis may be considered to remove amikacin from the blood in cases of severe toxicity, especially in patients with renal failure. Peritoneal dialysis is less effective. Contact a poison control center for guidance.
⏰ Missed Dose
This medicine is administered by a healthcare professional in a hospital or clinic setting. If you miss a scheduled dose, inform your healthcare provider as soon as possible. They will determine the appropriate action based on your dosing schedule. Do not attempt to self-administer a missed dose. If you are receiving this medicine at home through a home infusion service, contact your nurse or doctor immediately for instructions.
Additional Safety Advice
This medicine must only be given by a qualified healthcare professional in a monitored setting. Before starting treatment, inform your doctor about any kidney problems, hearing problems, muscle disorders such as myasthenia gravis, or allergies to antibiotics. Your doctor will monitor your kidney function and hearing during treatment. Stay well hydrated unless your doctor advises otherwise. Do not stop treatment early even if you feel better, as this can lead to resistant infections. Avoid taking other medicines that can harm the kidneys or hearing without consulting your doctor. This medicine is not for self-administration at home. If you experience any difficulty breathing, muscle weakness, or swelling, seek immediate medical attention.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of kidney damage and hearing loss from this medicine due to age-related decline in kidney function. Doses should be adjusted based on creatinine clearance. Close monitoring of kidney function and hearing is essential. Elderly patients may also be more susceptible to neuromuscular blockade. Use with caution.
🤰 Pregnancy Planning (TTC)
This medicine is classified as Pregnancy Category D and may cause fetal harm, including hearing loss. If you are planning pregnancy, discuss with your doctor before starting this medicine. Effective contraception should be used during treatment. If you become pregnant while on this medicine, inform your doctor immediately.
🏥 Post-Surgery Considerations
This medicine may be used after surgery to treat or prevent infections. It is important to monitor kidney function closely, especially if you are also receiving other nephrotoxic drugs or have pre-existing kidney problems. Follow your surgeon's instructions for wound care and follow-up.
🦷 Dental Procedures
Inform your dentist if you are receiving this medicine. It does not typically interact with dental anesthetics, but your dentist should be aware of your medical condition and medications. If you have a history of rheumatic heart disease or prosthetic heart valves, you may need prophylactic antibiotics for dental procedures; discuss with your doctor.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While receiving this medicine, you may feel weak or fatigued. Avoid strenuous exercise until you have recovered from the infection. If you experience muscle weakness or difficulty breathing, seek medical attention immediately. Light activity such as walking may be beneficial once you feel better, but consult your doctor first.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is typically administered in a hospital, so you will likely need to take time off work during treatment. You may experience fatigue, nausea, or dizziness, which can affect your ability to work or drive. Do not drive or operate heavy machinery if you feel unwell. Once you recover, you can gradually return to your normal activities. Discuss with your doctor when it is safe to resume work.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Stopping early can lead to incomplete treatment and antibiotic resistance. Your doctor will decide when to stop based on your clinical response, culture results, and kidney function. If you experience serious side effects such as hearing loss or kidney problems, your doctor may stop the medicine and switch to an alternative. Always follow your doctor's instructions.
📅 Long-Term Use Effects
Long-term use of this medicine can increase the risk of irreversible kidney damage and hearing loss. Prolonged therapy may also lead to superinfections with resistant organisms or fungi. Regular monitoring of kidney function and hearing is essential during extended treatment. The risk of toxicity increases with the duration of therapy and cumulative dose. If long-term therapy is necessary, your doctor will weigh the benefits against the risks and may consider alternative antibiotics.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Depending on the infection and susceptibility, other antibiotics such as beta-lactams, fluoroquinolones, or carbapenems may be used.
Evidence: Well-establishedSometimes this medicine is used in combination with other antibiotics for synergistic effects.
Evidence: Well-establishedFor certain infections, surgical drainage or removal of infected devices may be necessary in addition to antibiotics.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine may reduce the effectiveness of live bacterial vaccines. Avoid receiving live bacterial vaccines during treatment. Inactivated vaccines are generally safe. Consult your doctor about vaccination timing.
📦 Storage Guide
✅ DO
Store at controlled room temperature (20-25°C)
❌ DON'T
Do not freeze
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Protect from light
❌ DON'T
Do not store in direct sunlight
✅ DO
Check expiration date before use
❌ DON'T
Do not use if expired or if solution is discolored
✈️ Traveling with This Medicine
This medicine is typically administered in a hospital setting, so travel is usually not applicable. If you are receiving this medicine as part of a home infusion program and need to travel, consult your healthcare provider first. Carry the medicine in its original packaging with the prescription label. Bring a copy of your prescription and a letter from your doctor explaining the medical need. Check with airlines and customs about carrying injectable medicines. Store the medicine properly during travel, avoiding extreme temperatures. Plan for time zone differences if you have scheduled doses; your doctor can help adjust the timing.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling better within 24 to 48 hours after starting treatment, but it may take several days for the full effect. It is important to complete the full course as prescribed.
A: This medicine is usually given in a hospital or clinic setting by a healthcare professional. In some cases, it may be administered at home through a home infusion service under medical supervision.
A: Ringing in the ears is a sign of potential hearing damage. Report it to your doctor immediately. They may stop the medicine or adjust the dose.
A: This medicine can cause kidney damage, especially if you have pre-existing kidney problems or are taking other kidney-damaging drugs. Your doctor will monitor your kidney function closely.
A: This medicine is given in a hospital setting, so you should not drive immediately after receiving it. If you feel dizzy or weak, avoid driving until you feel normal.
🤔 Common Patient Concerns
🔄 Substitutes for amitax 50mg injection
View AllAlternative brands with exact same active ingredient:
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amycin 50mg injectionRedson Laboratories Pvt Ltd ₹15.00 57.9% COSTLIER
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ami tel 50mg injectionArtel Laboratories ₹15.00 57.9% COSTLIER
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acin 50mg injectionDomagk Pharma ₹16.10 69.5% COSTLIER
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Ticin 50mg InjectionHelax Healthcare Pvt. Ltd. ₹16.50 73.7% COSTLIER
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amcin 50mg injectionIntra Labs India Pvt Ltd ₹19.50 105.3% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Amikacin can be taken orally for infections.
Fact: Amikacin is not absorbed orally and must be given by injection. - Myth: Amikacin is safe for everyone.
Fact: Amikacin can cause kidney damage and hearing loss, and is not suitable for patients with certain conditions. - Myth: You can stop amikacin as soon as you feel better.
Fact: You must complete the full course as prescribed to prevent resistance and ensure the infection is fully treated. - Myth: Amikacin is a painkiller.
Fact: Amikacin is an antibiotic and does not relieve pain directly; it treats the underlying infection.
🔄 Alternative Options
Generic Alternatives
- Amikacin
Brand Alternatives
- Amitax 50mg injection
- Amikacin injection