amisafe 100mg injection - Uses, Price, Side Effects & Substitutes
What is amisafe 100mg injection used for?
Amikacin Sulphate 500mg Injection (Amikacin) is used to treat OPHTHAL. It contains Amikacin (100mg), which Binds to 30S ribosomal subunit, causing misreading of mRNA and inhibition of pro. Always consult your doctor before use. Take as prescribed.
- Generic Name: Amikacin
- Manufacturer: Indoco Remedies Ltd
- Form: Allopathy
- Pregnancy Category: D
- Prescription Required: Yes
๐ amisafe 100mg injection Uses & Benefits
Serious Gram-negative infections (sepsis, pneumonia, complicated UTI, intra-abdominal infections); adjunct in tuberculosis; neonatal sepsis.
Off-label uses: Brucellosis, Plague, Tularemia
๐ Drug Information
| Generic Name(s) | Amikacin |
| Brand Name | Amikacin Sulphate 500mg Injection |
| Manufacturer | Indoco Remedies Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | OPHTHAL |
| Action Class | Aminoglycosides |
| Route of Administration | Intramuscular, Intravenous |
| Storage | Store at 20-25ยฐC; protect from light; do not freeze. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Binds to 30S ribosomal subunit, causing misreading of mRNA and inhibition of protein synthesis.
Mechanism Steps
๐ก How to Take amisafe 100mg injection
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of amisafe 100mg injection
โ Common Side Effects
- Nephrotoxicity
- Ototoxicity (vestibular and cochlear)
- Nausea
- Vomiting
- Rash
๐จ Serious Side Effects
- Acute renal failure
- Irreversible hearing loss
- Neuromuscular blockade
- Anaphylaxis
โ ๏ธ Rare Side Effects
- Superinfection
- Clostridium difficile colitis
- Hypomagnesemia
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Neuromuscular blocking agents | Major | Enhanced neuromuscular blockade, respiratory depression |
| Cisplatin | Major | Increased nephrotoxicity and ototoxicity |
| Loop diuretics | Major | Increased ototoxicity |
| Vancomycin | Major | Increased nephrotoxicity |
| Penicillins | Moderate | Synergistic antibacterial effect |
| NSAIDs | Moderate | Increased nephrotoxicity risk |
๐จ Major Interactions
- Neuromuscular blocking agents
- Other aminoglycosides
- Cisplatin
- Loop diuretics
- Vancomycin
โก Moderate Interactions
- Penicillins (synergy)
- Cephalosporins
- NSAIDs
- Methoxyflurane
โน๏ธ Minor Interactions
- Dimercaprol
- Indomethacin
๐ฝ๏ธ Food Interactions
No significant food interactions.
๐ท Alcohol Interaction
No known interaction.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to amikacin or other aminoglycosides; myasthenia gravis; pre-existing severe renal impairment.
๐ Monitoring Parameters
Renal function (serum creatinine, BUN), urine output, audiometry, serum drug levels (peak and trough).
๐คฑ Lactation Safety
Caution; small amounts excreted in breast milk; monitor infant for diarrhea, candidiasis.
๐ Overdose Management
Supportive care; hemodialysis may enhance elimination; monitor renal function and hearing.
โฐ Missed Dose
Administer as soon as remembered; if near next dose, skip missed dose; do not double dose.
๐จโโ๏ธ Reviewed by Expert
๐ Substitutes for amisafe 100mg injection
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Medical Note: Always consult your doctor before switching medications.