aminophyllin 250mg injection - Aminophylline (250mg) medicine

Aminophyllin 250mg Injection - Uses, Price, Side Effects

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Aminophylline (250mg)

🏭 Biostan Indian Pharmaceuticals 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 5, 2026

📋 Prescription Required 💊 Generic Available

Medically Reviewed

SaathiMed Expert Panel | Sep 05, 2026

What is aminophyllin 250mg injection used for?

Aminophyllin 250mg Injection contains Aminophylline, a bronchodilator that relaxes muscles in the airways and increases air flow to the lungs. It is used to treat and prevent symptoms of asthma, chronic bronchitis, and emphysema. The injection is typically administered in a hospital setting for acute asthma attacks or severe COPD exacerbations.

Generic Name: Aminophylline
Manufacturer: Biostan Indian Pharmaceuticals
Form: Allopathy
Pregnancy Category: C
Prescription Required: Yes

💡 Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

💊 aminophyllin 250mg injection Uses & Benefits

Reversible airway obstruction in asthma and COPD, acute bronchospasm, status asthmaticus.

Off-label uses: Apnea of prematurity, bradycardia in neonates, acute renal colic (limited evidence).

📋 Drug Information

Generic Name(s)	Aminophylline
Brand Name	Aminophylline 250mg Injection
Manufacturer	Biostan Indian Pharmaceuticals
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	RESPIRATORY
Action Class	Theophylline & its derivatives
Route of Administration	Intravenous, intramuscular.
Storage	Store at 20-25°C (68-77°F); protect from light; do not freeze.
Shelf Life	As per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionRapidly absorbed after intramuscular injection; intravenous administration provides immediate availability.

DistributionDistributes widely into body tissues and fluids, including breast milk and across placenta.

Protein BindingApproximately 40% bound to plasma proteins.

MetabolismHepatic metabolism via demethylation and oxidation; primarily by CYP1A2, with minor contributions from CYP2E1 and CYP3A4.

Half-Life3-12 hours in adults; prolonged in neonates, elderly, and patients with hepatic or cardiac impairmen

ExcretionRenal excretion of metabolites and unchanged drug (about 10%).

Bioavailability100% for intravenous administration; variable for intramuscular (75-100%).

Onset of ActionIntravenous: within minutes; Intramuscular: 15-30 minutes.

Peak Plasma TimeIntravenous: immediately after infusion; Intramuscular: 1-2 hours.

Duration of Action4-6 hours (depending on formulation and individual metabolism).

How It Works

Inhibits phosphodiesterase, increasing intracellular cAMP; also antagonizes adenosine receptors.

Mechanism Steps

1Inhibition of phosphodiesterase enzymes (PDE3, PDE4) leading to increased intracellular cAMP.

2Increased cAMP activates protein kinase A, which phosphorylates target proteins.

3Phosphorylation leads to relaxation of bronchial smooth muscle (bronchodilation).

💡 How to Take aminophyllin 250mg injection

Follow your doctor's prescription exactly.

Dosage Timeline

🌅 Morning ✅ ☀️ Afternoon ❌ 🌆 Evening ✅ 🌙 Night ❌

⚠️ Side Effects of aminophyllin 250mg injection

✅ Common Side Effects

Nausea
Vomiting
Headache
Insomnia
Nervousness
Tachycardia

🚨 Serious Side Effects

Seizures
Arrhythmias
Hypotension
Respiratory arrest
Severe hypersensitivity reactions

⚠️ Rare Side Effects

Hypercalcemia
Rhabdomyolysis
Acute pancreatitis
Alopecia
SIADH

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug	Severity	Effect
Cimetidine	Major	Increased aminophylline levels, risk of toxicity
Ciprofloxacin	Major	Increased aminophylline levels, risk of toxicity
Lithium	Moderate	Decreased lithium excretion, increased lithium levels

🚨 Major Interactions

Cimetidine
Ciprofloxacin
Erythromycin
Fluvoxamine
Mexiletine
Propafenone
Tacrine
Thiabendazole
Ticlopidine
Verapamil

⚡ Moderate Interactions

Allopurinol
Carbamazepine
Diltiazem
Disulfiram
Enoxacin
Interferon alfa
Methotrexate
Nifedipine
Norfloxacin
Oral contraceptives
Phenytoin
Ranitidine
Rifampin
St. John's Wort
Sulfinpyrazone
Thyroid hormones
Tobacco smoking

ℹ️ Minor Interactions

Adenosine
Benzodiazepines
Beta-blockers
Caffeine
Halothane
Isoniazid
Ketamine
Lithium
Macrolides (except erythromycin)
Pancuronium
Theophylline

🍽️ Food Interactions

High-fat meals may delay absorption; caffeine-containing foods may increase side effects.

🍷 Alcohol Interaction

Alcohol may increase the risk of side effects such as nausea and dizziness.

🛡️ Safety & Warnings

Liver

Moderate

Kidney

Moderate

Heart

High

Pregnancy

Category C

🚫 Contraindications

Hypersensitivity to aminophylline or theophylline, uncontrolled arrhythmias, hyperthyroidism, peptic ulcer, seizure disorders (unless adequately controlled).

📊 Monitoring Parameters

Serum theophylline levels (therapeutic range 10-20 mcg/mL), heart rate, respiratory rate, CNS effects, signs of toxicity.

🤱 Lactation Safety

Excreted in breast milk; use with caution, monitor infant for irritability and insomnia.

💊 Overdose Management

Activated charcoal, supportive care, monitoring of serum theophylline levels, management of seizures and arrhythmias; hemodialysis in severe cases.

⏰ Missed Dose

If on intermittent therapy, administer as soon as remembered; if close to next dose, skip missed dose. Do not double dose.

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Sep 05, 2026

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🔄 Substitutes for aminophyllin 250mg injection

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Alternative brands with exact same active ingredient (Aminophylline (250mg)):

biofylin 250mg injection

Biostan Indian Pharmaceuticals ₹20.63 SAME PRICE

Medical Note: Always consult your doctor before switching medications.