amigatin ls 100mg/10mg tablet - Uses, Price, Side Effects & Substitutes
What is amigatin ls 100mg/10mg tablet used for?
Amigaba LS Tablet (Gabapentin + Amitriptyline) is used to treat NEURO CNS. It contains Gabapentin (100mg) + Amitriptyline (10mg), which Gabapentin: Binds to ฮฑ2ฮด subunit of voltage-gated calcium channels, reducing n. Always consult your doctor before use. Take as prescribed.
- Generic Name: Gabapentin + Amitriptyline
- Manufacturer: Crescent Therapeutics Ltd
- Form: Allopathy
- Pregnancy Category: C
- Prescription Required: Yes
๐ amigatin ls 100mg/10mg tablet Uses & Benefits
Neuropathic pain, fibromyalgia, depression, anxiety, migraine prophylaxis.
Off-label uses: Chronic pain, restless legs syndrome, social anxiety disorder.
๐ Drug Information
| Generic Name(s) | Gabapentin + Amitriptyline |
| Brand Name | Amigaba LS Tablet |
| Manufacturer | Crescent Therapeutics Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | Anticonvulsant + Tricyclic Antidepressant |
| Route of Administration | Oral |
| Storage | Store at 20-25ยฐC, protect from light and moisture. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Gabapentin: Binds to ฮฑ2ฮด subunit of voltage-gated calcium channels, reducing neurotransmitter release. Amitriptyline: Inhibits reuptake of serotonin and norepinephrine, blocks histamine, acetylcholine, and ฮฑ1-adrenergic receptors.
Mechanism Steps
๐ก How to Take amigatin ls 100mg/10mg tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of amigatin ls 100mg/10mg tablet
โ Common Side Effects
- Drowsiness
- Dizziness
- Dry mouth
- Blurred vision
- Constipation
- Weight gain
๐จ Serious Side Effects
- Suicidal thoughts
- Seizures
- QT prolongation
- Serotonin syndrome
- Agranulocytosis
โ ๏ธ Rare Side Effects
- Hepatotoxicity
- Pancreatitis
- Rhabdomyolysis
- Stevens-Johnson syndrome
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| MAOIs | Major | Risk of serotonin syndrome, hypertensive crisis |
| CNS depressants | Major | Enhanced sedation, respiratory depression |
| Anticholinergics | Major | Additive anticholinergic effects |
| CYP2D6 inhibitors | Moderate | Increased amitriptyline levels |
| CYP3A4 inhibitors | Moderate | Increased amitriptyline levels |
| Anticoagulants | Moderate | Increased bleeding risk |
| Cimetidine | Minor | Increased amitriptyline levels |
| Antacids | Minor | Decreased gabapentin absorption |
๐จ Major Interactions
- MAOIs
- CNS depressants
- Anticholinergics
โก Moderate Interactions
- CYP2D6 inhibitors
- CYP3A4 inhibitors
- Anticoagulants
โน๏ธ Minor Interactions
- Cimetidine
- Antacids
๐ฝ๏ธ Food Interactions
Gabapentin: High-fat meal may decrease absorption; Amitriptyline: Avoid grapefruit juice.
๐ท Alcohol Interaction
Increased CNS depression; avoid alcohol.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity, recent MI, MAOI use within 14 days, narrow-angle glaucoma, urinary retention, severe hepatic impairment.
๐ Monitoring Parameters
ECG, liver function, renal function, serum drug levels (amitriptyline), suicidal ideation, sedation.
๐คฑ Lactation Safety
Not recommended; excreted in breast milk.
๐ Overdose Management
Supportive care; activated charcoal, ECG monitoring, benzodiazepines for seizures, sodium bicarbonate for arrhythmias.
โฐ Missed Dose
Take as soon as remembered unless near next dose; do not double dose.