amcold syrup - Cetirizine (5mg/5ml) + Ambroxol (30mg/5ml) medicine

amcold syrup - Uses, Price, Side Effects & Substitutes

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๐Ÿญ Cipla Ltd ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Jun 27, 2026
๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
Dr. SaathiMed Expert Panel | Jun 27, 2026

What is amcold syrup used for?

Amcold (Cetirizine + Ambroxol) is used to treat RESPIRATORY. It contains Cetirizine (5mg/5ml) + Ambroxol (30mg/5ml), which Cetirizine: Selective H1 receptor antagonist; Ambroxol: Increases airway secreti. Always consult your doctor before use. Take as prescribed.

  • Generic Name: Cetirizine + Ambroxol
  • Manufacturer: Cipla Ltd
  • Form: Allopathy
  • Pregnancy Category: A
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? Over 80% of the antiretroviral drugs used globally to combat AIDS are supplied by Indian pharmaceutical companies.

๐Ÿ’Š amcold syrup Uses & Benefits

Allergic rhinitis, cough with thick mucus, upper respiratory tract infections

Off-label uses: Chronic urticaria, COPD exacerbations

๐Ÿ“‹ Drug Information

Generic Name(s)Cetirizine + Ambroxol
Brand NameAmcold
ManufacturerCipla Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassRESPIRATORY
Action ClassAntihistamine + Mucolytic
Route of AdministrationOral
StorageStore at 25ยฐC (77ยฐF); protect from light and moisture
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionCetirizine: Well absorbed orally; Ambroxol: Rapidly absorbed from GI tract
DistributionCetirizine: Vd 0.5 L/kg; Ambroxol: Widely distributed, crosses placenta
Protein BindingCetirizine: 93%; Ambroxol: 90%
MetabolismCetirizine: Minimal hepatic metabolism; Ambroxol: Hepatic via glucuronidation
Half-LifeCetirizine: 8-11 hours; Ambroxol: 7-12 hours
ExcretionCetirizine: Renal (60% unchanged); Ambroxol: Renal (90% as metabolites)
BioavailabilityCetirizine: ~70%; Ambroxol: ~70-80%
Onset of ActionCetirizine: 1 hour; Ambroxol: 30 minutes
Peak Plasma TimeCetirizine: 1-2 hours; Ambroxol: 1-3 hours
Duration of ActionCetirizine: 24 hours; Ambroxol: 6-12 hours

How It Works

Cetirizine: Selective H1 receptor antagonist; Ambroxol: Increases airway secretion and reduces mucus viscosity

Mechanism Steps

1Cetirizine blocks H1 receptors, preventing histamine-mediated allergic responses
2Ambroxol stimulates serous bronchial glands, increasing fluid secretion
3Ambroxol depolymerizes mucopolysaccharides, reducing mucus viscosity

๐Ÿ’ก How to Take amcold syrup

Follow your doctor's prescription exactly.

โš ๏ธ Side Effects of amcold syrup

โœ… Common Side Effects

  • Drowsiness
  • Dry mouth
  • Fatigue
  • Nausea

๐Ÿšจ Serious Side Effects

  • Severe allergic reactions
  • Hepatotoxicity (rare)
  • Arrhythmias (rare)

โš ๏ธ Rare Side Effects

  • Thrombocytopenia
  • Stevens-Johnson syndrome
  • Anaphylaxis

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
CNS depressants Major Enhanced sedation
Alcohol Major Increased CNS depression
MAOIs Major Risk of hypertensive crisis
Anticholinergics Moderate Additive anticholinergic effects
CYP3A4 inhibitors Moderate Increased ambroxol levels
Theophylline Minor Possible increased theophylline levels
Digoxin Minor Possible increased digoxin levels

๐Ÿšจ Major Interactions

  • CNS depressants
  • Alcohol
  • MAOIs

โšก Moderate Interactions

  • Anticholinergics
  • CYP3A4 inhibitors

โ„น๏ธ Minor Interactions

  • Theophylline
  • Digoxin

๐Ÿฝ๏ธ Food Interactions

Food may delay absorption of cetirizine

๐Ÿท Alcohol Interaction

Increased CNS depression

๐Ÿ›ก๏ธ Safety & Warnings

๐Ÿšซ Contraindications

Hypersensitivity to any component, severe renal impairment (CrCl <10 mL/min)

๐Ÿ“Š Monitoring Parameters

Renal function, CNS effects, respiratory status

๐Ÿคฑ Lactation Safety

Cetirizine excreted in milk; Ambroxol likely safe

๐Ÿ’Š Overdose Management

Symptomatic and supportive; gastric lavage if recent

โฐ Missed Dose

Take as soon as remembered; skip if almost time for next dose

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

Dr. SaathiMed Expert Panel

MD, PhD - Pharmacology

Reviewed: Jun 27, 2026

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