ambigesic mr tablet - Chlorzoxazone (250mg) + Diclofenac (50mg) medicine

ambigesic mr tablet - Uses, Price, Side Effects & Substitutes

No reviews yet
๐Ÿญ Ambition Pharma Pvt Ltd ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Jun 26, 2026
๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
Dr. SaathiMed Expert Panel | Jun 26, 2026

What is ambigesic mr tablet used for?

Ache X Tablet (Chlorzoxazone + Diclofenac) is used to treat PAIN ANALGESICS. It contains Chlorzoxazone (250mg) + Diclofenac (50mg), which Chlorzoxazone: Depresses CNS; Diclofenac: Inhibits COX-1/2. Always consult your doctor before use. Take as prescribed.

  • Generic Name: Chlorzoxazone + Diclofenac
  • Manufacturer: Ambition Pharma Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: A
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

๐Ÿ’Š ambigesic mr tablet Uses & Benefits

Acute musculoskeletal pain, muscle spasms

Off-label uses: Chronic pain (not recommended)

๐Ÿ“‹ Drug Information

Generic Name(s)Chlorzoxazone + Diclofenac
Brand NameAche X Tablet
ManufacturerAmbition Pharma Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassPAIN ANALGESICS
Action ClassMuscle Relaxant + NSAID
Route of AdministrationOral
StorageStore at 20-25ยฐC, protect from moisture
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionWell absorbed orally
DistributionDistributes widely; crosses placenta
Protein BindingChlorzoxazone: 13-18%; Diclofenac: >99%
MetabolismChlorzoxazone: Hepatic (CYP2E1); Diclofenac: Hepatic (CYP2C9)
Half-LifeChlorzoxazone: 1-2 hrs; Diclofenac: 2 hrs
ExcretionUrine (metabolites)
BioavailabilityChlorzoxazone: ~100%; Diclofenac: ~50%
Onset of Action30-60 minutes
Peak Plasma Time1-2 hours
Duration of Action4-6 hours

How It Works

Chlorzoxazone: Depresses CNS; Diclofenac: Inhibits COX-1/2

Mechanism Steps

1Chlorzoxazone acts on CNS to depress reflexes and relax muscles
2Diclofenac inhibits cyclooxygenase (COX-1 and COX-2) enzymes
3COX inhibition reduces prostaglandin synthesis

๐Ÿ’ก How to Take ambigesic mr tablet

Follow your doctor's prescription exactly.

โš ๏ธ Side Effects of ambigesic mr tablet

โœ… Common Side Effects

  • Drowsiness
  • Dizziness
  • Nausea
  • Dyspepsia
  • Headache

๐Ÿšจ Serious Side Effects

  • GI bleeding
  • Hepatotoxicity
  • Renal failure
  • Anaphylaxis

โš ๏ธ Rare Side Effects

  • Blood dyscrasias
  • Stevens-Johnson syndrome
  • Pancreatitis

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
Warfarin Major Increased bleeding risk
Aspirin Major Increased GI ulceration risk
Lithium Major Increased lithium toxicity
Methotrexate Major Increased methotrexate toxicity
CYP2C9 inhibitors Major Increased diclofenac levels
ACE inhibitors Moderate Reduced antihypertensive effect
Diuretics Moderate Reduced diuretic effect
Anticoagulants Moderate Increased bleeding risk
Corticosteroids Moderate Increased GI ulceration risk
Antacids Minor Reduced absorption
Caffeine Minor Increased CNS stimulation

๐Ÿšจ Major Interactions

  • Warfarin
  • Aspirin
  • Lithium
  • Methotrexate
  • CYP2C9 inhibitors

โšก Moderate Interactions

  • ACE inhibitors
  • Diuretics
  • Anticoagulants
  • Corticosteroids

โ„น๏ธ Minor Interactions

  • Antacids
  • Caffeine

๐Ÿฝ๏ธ Food Interactions

Food may delay absorption

๐Ÿท Alcohol Interaction

Increased hepatotoxicity risk

๐Ÿ›ก๏ธ Safety & Warnings

๐Ÿšซ Contraindications

Hypersensitivity, active GI bleeding, severe hepatic/renal impairment, history of asthma with NSAIDs, third trimester pregnancy

๐Ÿ“Š Monitoring Parameters

Liver function, renal function, CBC, signs of GI bleeding

๐Ÿคฑ Lactation Safety

Not recommended; excreted in milk

๐Ÿ’Š Overdose Management

Symptomatic and supportive; gastric lavage, activated charcoal

โฐ Missed Dose

Take as soon as remembered; skip if near next dose

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

Dr. SaathiMed Expert Panel

MD, PhD - Pharmacology

Reviewed: Jun 26, 2026

๐Ÿ”— View Profile

๐Ÿ˜Š Was this information helpful?

Browse Medicines A-Z

Search our extensive medical database alphabetically.

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Back to Medicines Directory
SaathiMed App
SaathiMed App Consult doctors & order medicines faster
Install